PCIDB

KNApSAcK Metabolite C00003416

Metabolite

KNApSAcK Entry

id C00003416
Name Coleonol / Forskolin
CAS RN 66575-29-9
Standard InChI InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3

Cluster

Phytochemical cluster No. 41
KCF-S cluster No. 531

Link

ChEMBL

By standard InChI CHEMBL52606
By standard InChI Main Layer CHEMBL52606 CHEMBL147623 CHEMBL1358402 CHEMBL1398667 CHEMBL1414148 CHEMBL1473060 CHEMBL1904897 CHEMBL1990053

KEGG

By LinkDB C09076

CTD

By CAS RN

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Lamiaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Coleus forskohlii 41228 Lamiaceae asterids Viridiplantae

Human Protein / Gene in interaction

46 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1398667 CHEMBL1473060 CHEMBL1614110 (1) CHEMBL1741321 (2)
1 / 0
P13569 Cystic fibrosis transmembrane conductance regulator chloride CHEMBL52606 CHEMBL661349 (1)
2 / 3
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1414148 CHEMBL1613842 (1)
4 / 2
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1358402 CHEMBL2114744 (1)
0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor CHEMBL52606 CHEMBL901742 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1398667 CHEMBL1473060 CHEMBL1614281 (2) CHEMBL1614361 (2)
3 / 2
P11166 Solute carrier family 2, facilitated glucose transporter member 1 Glucose uniporter CHEMBL52606 CHEMBL684234 (1)
4 / 2
P08183 Multidrug resistance protein 1 drug CHEMBL52606 CHEMBL2076213 (1) CHEMBL2076214 (1)
CHEMBL2076218 (1)
1 / 0
Q08828 Adenylate cyclase type 1 Enzyme CHEMBL52606 CHEMBL646259 (1) CHEMBL645667 (1)
CHEMBL645668 (1) CHEMBL645672 (1)
CHEMBL645673 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1398667 CHEMBL1473060 CHEMBL1741325 (2)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL1358402 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9HBX9 Relaxin receptor 1 Relaxin receptor CHEMBL52606 CHEMBL1738202 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1398667 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL52606 CHEMBL1358402 CHEMBL1613941 (1) CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL52606 CHEMBL2114931 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL52606 CHEMBL1614410 (1)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL52606 CHEMBL1794401 (1)
0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL52606 CHEMBL2354292 (1)
2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL52606 CHEMBL1794293 (1)
5 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1358402 CHEMBL1398667 CHEMBL1414148 CHEMBL1473060 CHEMBL1614521 (2) CHEMBL1613808 (3)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1398667 CHEMBL1473060 CHEMBL1741322 (2)
0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL1358402 CHEMBL1614171 (1)
5 / 2
Q8WXD0 Relaxin receptor 2 Relaxin receptor CHEMBL52606 CHEMBL1738172 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1358402 CHEMBL1737868 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL52606 CHEMBL1794364 (1) CHEMBL1794542 (1)
1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1398667 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
Q8WUI4 Histone deacetylase 7 Hydrolase CHEMBL52606 CHEMBL1267832 (1) CHEMBL1267833 (1)
CHEMBL1267834 (1) CHEMBL1267835 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1398667 CHEMBL1473060 CHEMBL1613777 (1) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1398667 CHEMBL1414148 CHEMBL1473060 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (2)
0 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL1358402 CHEMBL1614052 (1)
1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL52606 CHEMBL2114890 (1)
0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL52606 CHEMBL690192 (1) CHEMBL695976 (1)
1 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL52606 CHEMBL2114849 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1904897 CHEMBL1794536 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1358402 CHEMBL1738442 (1)
0 / 0
O60266 Adenylate cyclase type 3 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
O43306 Adenylate cyclase type 6 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
Q08462 Adenylate cyclase type 2 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
O60503 Adenylate cyclase type 9 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
P51828 Adenylate cyclase type 7 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
P40145 Adenylate cyclase type 8 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
O95622 Adenylate cyclase type 5 Enzyme CHEMBL52606 CHEMBL646259 (1)
1 / 0
Q8NFM4 Adenylate cyclase type 4 Enzyme CHEMBL52606 CHEMBL646259 (1)
0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL52606 CHEMBL806152 (1) CHEMBL806154 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL52606 CHEMBL806152 (1) CHEMBL806154 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL52606 CHEMBL806152 (1) CHEMBL806154 (1)
3 / 2

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#219050 Cryptorchidism, unilateral or bilateral Q8WXD0
#219700 Cystic fibrosis; cf P13569
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#606703 Dyskinesia, familial, with facial myokymia; fdfm O95622
#601042 Dystonia 9; dyt9 P11166
#614847 Epilepsy, idiopathic generalized, susceptibility to, 12; eig12 P11166
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#137800 Glioma susceptibility 1; glm1 P37231
#606777 Glut1 deficiency syndrome 1; glut1ds1 P11166
#612126 Glut1 deficiency syndrome 2; glut1ds2 P11166
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#601665 Obesity P37231
#614674 Periodic fever, menstrual cycle-dependent P08908
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#277180 Vas deferens, congenital bilateral aplasia of; cbavd P13569

KEGG DISEASE (28)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00831 Primary dystonia P11166 (related)
H00836 GLUT1 deficiency syndrome (GLUT1DS) P11166 (related)
H01205 Coumarin resistance P11712 (related)
H00218 Cystic fibrosis (CF) P13569 (related)
H00933 Hereditary pancreatitis P13569 (related)
H01033 Congenital bilateral absence of vas deferens P13569 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00609 46,XY disorders of sex development (Other) Q8WXD0 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)