PCIDB

KNApSAcK Metabolite C00003429

Metabolite

KNApSAcK Entry

id C00003429
Name Ginkgolide A
CAS RN 15291-75-5
Standard InChI InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1
Standard InChI (Main Layer) InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3

Cluster

Phytochemical cluster No. 44
KCF-S cluster No. 2137

Link

ChEMBL

By standard InChI CHEMBL465161
By standard InChI Main Layer CHEMBL465161 CHEMBL1370614 CHEMBL1408113 CHEMBL1472160 CHEMBL1712596 CHEMBL1741996 CHEMBL2112174

KEGG

By LinkDB C07601

CTD

By CAS RN

Human Protein / Gene in interaction

13 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1741996 CHEMBL1741321 (1)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1472160 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1712596 CHEMBL1738312 (1)
0 / 0
P23415 Glycine receptor subunit alpha-1 GLR alpha CHEMBL465161 CHEMBL915380 (2) CHEMBL915381 (2)
CHEMBL915383 (1)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1741996 CHEMBL1741325 (1)
0 / 1
P23416 Glycine receptor subunit alpha-2 GLR alpha CHEMBL465161 CHEMBL915382 (2)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL465161 CHEMBL1408113 CHEMBL1614410 (1) CHEMBL1614531 (1)
1 / 3
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL1712596 CHEMBL1963893 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1741996 CHEMBL1741322 (1)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL2112174 CHEMBL760444 (1) CHEMBL760445 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1741996 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1741996 CHEMBL1741324 (1)
0 / 1
O00255 Menin Unclassified protein CHEMBL1408113 CHEMBL1614531 (1)
2 / 5

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#149400 Hyperekplexia, hereditary 1; hkpx1 P23415
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (12)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00769 Hyperekplexia P23415 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)