KNApSAcK Metabolite C00035831
Metabolite
KNApSAcK Entry
| id | C00035831 |
|---|---|
| Name | Ginkgolide C |
| CAS RN | 15291-76-6 |
| Standard InChI | InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3 |
| Standard InChI (Main Layer) | InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3 |
Cluster
| Phytochemical cluster | No. 44 |
|---|---|
| KCF-S cluster | No. 2137 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL156251 CHEMBL347488 CHEMBL375821 CHEMBL1299408 CHEMBL1596335 CHEMBL1868593 CHEMBL2112173 |
KEGG
| By LinkDB | C07603 |
|---|
CTD
| By CAS RN | C058295 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Ginkgoaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Ginkgo biloba | 3311 | Ginkgoaceae | Spermatophyta | Viridiplantae |
Human Protein / Gene in interaction
8 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P23415 | Glycine receptor subunit alpha-1 | GLR alpha | CHEMBL375821 |
CHEMBL915380
(1)
CHEMBL915381
(1)
|
1 / 1 |
| O75496 | Geminin | Unclassified protein | CHEMBL1299408 |
CHEMBL2114843
(1)
|
0 / 0 |
| P23416 | Glycine receptor subunit alpha-2 | GLR alpha | CHEMBL375821 |
CHEMBL915382
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1868593 |
CHEMBL1794401
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL1596335 |
CHEMBL1613808
(1)
|
0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | CHEMBL2112173 |
CHEMBL760444
(1)
CHEMBL760445
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1299408 |
CHEMBL1614211
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1299408 |
CHEMBL1613914
(1)
|
0 / 0 |
CTD interaction (11)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C058295 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
decreases phosphorylation
/ decreases reaction |
protein |
18001288
|
| C058295 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein |
affects activity
/ affects cotreatment |
protein |
21329749
|
| C058295 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|
| C058295 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21329749
|