PCIDB

KNApSAcK Metabolite C00037771

Metabolite

KNApSAcK Entry

id C00037771
Name S-Allylcysteine
CAS RN 21593-77-1
Standard InChI InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1
Standard InChI (Main Layer) InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)

Cluster

Phytochemical cluster
KCF-S cluster No. 6469

Link

ChEMBL

By standard InChI CHEMBL2048654
By standard InChI Main Layer CHEMBL1592541 CHEMBL2048654

KEGG

By LinkDB C16759

CTD

By CAS RN C065299

Species

Summary

Plant class

class name count
Liliopsida 1

Family

family name count
Amaryllidaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Allium tuberosum Rottl.ex Spreng. 4678 Amaryllidaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1592541 CHEMBL1614458 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1592541 CHEMBL1613914 (1)
0 / 0
P37088 Amiloride-sensitive sodium channel subunit alpha NA CHEMBL2048654 CHEMBL2051232 (1)
2 / 2
P51168 Amiloride-sensitive sodium channel subunit beta Unclassified protein CHEMBL2048654 CHEMBL2051232 (1)
3 / 3
P51170 Amiloride-sensitive sodium channel subunit gamma Unclassified protein CHEMBL2048654 CHEMBL2051232 (1)
2 / 3

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C065299 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 S-allylcysteine results in decreased expression of BCL2 protein decreases expression
protein 17155983
C065299 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) S-allylcysteine results in increased cleavage of CASP3 protein increases cleavage
protein 17155983
C065299 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) S-allylcysteine results in increased expression of CDH1 protein increases expression
protein 17155983
C065299 3728 JUP
ARVD12
CTNNG
DP3
DPIII
PDGB
PKGB
junction plakoglobin S-allylcysteine results in increased expression of JUP protein increases expression
protein 17155983

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#211400 Bronchiectasis with or without elevated sweat chloride 1; besc1 P51168
#613021 Bronchiectasis with or without elevated sweat chloride 2; besc2 P37088
#613071 Bronchiectasis with or without elevated sweat chloride 3; besc3 P51170
#177200 Liddle syndrome P51168
P51170
#264350 Pseudohypoaldosteronism, type i, autosomal recessive; pha1b P37088
P51168

KEGG DISEASE (3)

KEGG disease name UniProt
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4) P37088 (related)
P51168 (related)
P51170 (related)
H00892 Bronchiectasis with or without elevated sweat chloride P37088 (related)
P51168 (related)
P51170 (related)
H00242 Liddle syndrome P51168 (related)
P51170 (related)

Diseases related to CTD interactions

6 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003921 C065299 Diabetes Mellitus, Experimental therapeutic
20951120
D006331 C065299 Heart Diseases therapeutic
17182065
D009203 C065299 Myocardial Infarction therapeutic
16757080
19067678
D011471 C065299 Prostatic Neoplasms therapeutic
17155983
D011658 C065299 Pulmonary Fibrosis therapeutic
16614485
D001745 C065299 Urinary Bladder Diseases therapeutic
18786597