PCIDB

KNApSAcK Metabolite C00007936

Metabolite

KNApSAcK Entry

id C00007936
Name Phloretin
CAS RN 60-82-2
Standard InChI InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
Standard InChI (Main Layer) InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 548

Link

ChEMBL

By standard InChI CHEMBL45068
By standard InChI Main Layer CHEMBL45068

KEGG

By LinkDB C00774

CTD

By CAS RN D010693

Human Protein / Gene in interaction

47 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL45068 CHEMBL1614110 (2) CHEMBL1741321 (1)
1 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL45068 CHEMBL2076020 (1) CHEMBL2076031 (1)
0 / 0
P13866 Sodium/glucose cotransporter 1 Glucose CHEMBL45068 CHEMBL809058 (1)
1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL45068 CHEMBL1613992 (1)
7 / 44
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL45068 CHEMBL1794499 (1)
2 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL45068 CHEMBL1794573 (1)
2 / 2
P06746 DNA polymerase beta Enzyme CHEMBL45068 CHEMBL1614079 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL45068 CHEMBL1613818 (2)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL45068 CHEMBL1614076 (1)
1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily CHEMBL45068 CHEMBL1614153 (1)
1 / 4
Q9HAS3 Solute carrier family 28 member 3 Unclassified protein CHEMBL45068 CHEMBL957102 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL45068 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL45068 CHEMBL1614281 (1) CHEMBL1614361 (2)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL45068 CHEMBL1614554 (1)
3 / 1
P08183 Multidrug resistance protein 1 drug CHEMBL45068 CHEMBL2077116 (1)
1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL45068 CHEMBL1614027 (2) CHEMBL1741325 (1)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL45068 CHEMBL970971 (1)
1 / 11
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL45068 CHEMBL1014697 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL45068 CHEMBL1613800 (2)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL45068 CHEMBL1614458 (2)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL45068 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL45068 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL45068 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL45068 CHEMBL2114780 (1)
0 / 0
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x CHEMBL45068 CHEMBL767233 (1)
1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL45068 CHEMBL1614257 (2) CHEMBL1614410 (1)
CHEMBL1614531 (1)
1 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL45068 CHEMBL1794467 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL45068 CHEMBL1614521 (1) CHEMBL1613808 (2)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL45068 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL45068 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL45068 CHEMBL2076819 (1) CHEMBL2076834 (1)
2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL45068 CHEMBL1614038 (3)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL45068 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL45068 CHEMBL1738675 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL45068 CHEMBL1613777 (2) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL45068 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL45068 CHEMBL1614421 (1) CHEMBL1614502 (4)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL45068 CHEMBL1738402 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL45068 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL45068 CHEMBL1613914 (3)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL45068 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL45068 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL45068 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL45068 CHEMBL1614257 (2) CHEMBL1614531 (1)
2 / 5
O15427 Monocarboxylate transporter 4 Unclassified protein CHEMBL45068 CHEMBL2077069 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL45068 CHEMBL2114738 (1)
0 / 0
Q9HCT0 Fibroblast growth factor 22 Unclassified protein CHEMBL45068 CHEMBL2354256 (1)
0 / 0

CTD interaction (20)

compound gene gene name gene description interaction interaction type form reference
pmid
D010693 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 17177569
D010693 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 17177569
D010693 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] decreases reaction
/ increases expression
protein 17177569
D010693 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Phloretin binds to and results in increased activity of ESR1 protein affects binding
/ increases activity
protein 9751507
D010693 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Phloretin binds to and results in increased activity of ESR2 protein affects binding
/ increases activity
protein 9751507
D010693 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Phloretin binds to ESR2 protein affects binding
protein 12224631
D010693 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) Phloretin results in decreased activity of GSK3B protein decreases activity
protein 16968061
D010693 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] decreases reaction
/ increases secretion
protein 21051542
D010693 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] decreases reaction
/ increases activity
/ increases secretion
protein 17965850
D010693 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Phloretin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA] decreases reaction
/ increases expression
mRNA 20021702
D010693 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Phloretin results in decreased expression of NOS3 mRNA decreases expression
mRNA 20021702
D010693 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 Phloretin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] affects transport
/ decreases reaction
protein 14642735
D010693 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 Phloretin results in decreased activity of SLC2A1 protein decreases activity
protein 14642735
D010693 6548 SLC9A1
APNH
NHE-1
NHE1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]] affects cotreatment
/ affects transport
/ decreases reaction
protein 12765964
D010693 6548 SLC9A1
APNH
NHE-1
NHE1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 Phloretin results in decreased activity of SLC9A1 protein decreases activity
protein 12765964
D010693 6548 SLC9A1
APNH
NHE-1
NHE1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 Phloretin results in decreased activity of SLC9A1 protein alternative form decreases activity
protein 12765964
D010693 133308 SLC9B2
NHA2
NHE10
NHEDC2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Phloretin results in decreased activity of SLC9B2 protein decreases activity
protein 18000046
D010693 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Phloretin increases glucuronidation
protein 14557274
D010693 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of Phloretin increases glucuronidation
protein 14557274
D010693 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Phloretin increases glucuronidation
protein 14557274

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (63)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#208900 Ataxia-telangiectasia; at Q13315
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#606824 Glucose/galactose malabsorption; ggm P13866
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (81)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
Q13315 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)