PCIDB

KNApSAcK Metabolite C00000911

Metabolite

KNApSAcK Entry

id C00000911
Name Lycopene / all-trans-Lycopene
CAS RN 502-65-8
Standard InChI InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+
Standard InChI (Main Layer) InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3

Cluster

Phytochemical cluster No. 59
KCF-S cluster No. 97

Link

ChEMBL

By standard InChI CHEMBL501174
By standard InChI Main Layer CHEMBL501174 CHEMBL1984187

KEGG

By LinkDB C05432

CTD

By CAS RN C015329

Species

Summary

Plant class

class name count
rosids 7
asterids 4

Family (Top 10)

family name count
Enterobacteriaceae 3
Rhodobacteraceae 2
Brassicaceae 2
Apiaceae 1
Rhizobiaceae 1
Nostocaceae 1
Solanaceae 1
Asteraceae 1
Rutaceae 1
Cucurbitaceae 1

List (23)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Agrobacterium aurantiacum 44155 Rhizobiaceae Bacteria
Anabaena sp. Strain PCC7120 1163 Nostocaceae Bacteria
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Brassica napus 3708 Brassicaceae rosids Viridiplantae
Calendula officinalis 41496 Asteraceae asterids Viridiplantae
Citrus spp. 2706 Rutaceae rosids Viridiplantae
Daucus carota 4039 Apiaceae asterids Viridiplantae
Diospyros kaki 35925 Ebenaceae asterids Viridiplantae
Erwinia herbicola strain Eho10 551 Enterobacteriaceae Bacteria
Erwinia herbicola strain Eho13 551 Enterobacteriaceae Bacteria
Erwinia uredovora 553 Enterobacteriaceae Bacteria
Flavobacterium sp. Strain R1534 237 Flavobacteriaceae Bacteria
Lycopersicon esculentum 4081 Solanaceae asterids Viridiplantae
Momordica charantia 3673 Cucurbitaceae rosids Viridiplantae
Myxococcus xanthus 34 Myxococcaceae Bacteria
Passiflora edulis 78168 Passifloraceae rosids Viridiplantae
Psidium guajava 120290 Myrtaceae rosids Viridiplantae
Rhodobacter capsulatus 1061 Rhodobacteraceae Bacteria
Rhodobacter sphaeroides 1063 Rhodobacteraceae Bacteria
Rhodopseudomonas spp. 1073 Bradyrhizobiaceae Bacteria
Rosa canina 74635 Rosaceae rosids Viridiplantae
Streptomyces griseus 1911 Streptomycetaceae Bacteria
Synechococcus sp. strain PCC7942 1129 Bacteria

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein CHEMBL501174 CHEMBL1614544 (1)
11 / 10
P11473 Vitamin D3 receptor NR1I1 CHEMBL501174 CHEMBL1794311 (1)
2 / 3
O75496 Geminin Unclassified protein CHEMBL501174 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL501174 CHEMBL1794467 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL501174 CHEMBL1794536 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL501174 CHEMBL1738442 (1)
0 / 0

CTD interaction (114)

compound gene gene name gene description interaction interaction type form reference
pmid
C015329 118 ADD1
ADDA
adducin 1 (alpha) lycopene results in decreased expression of ADD1 mRNA decreases expression
mRNA 16886892
C015329 177 AGER
RAGE
advanced glycosylation end product-specific receptor lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] decreases reaction
/ increases expression
protein 22429818
C015329 177 AGER
RAGE
advanced glycosylation end product-specific receptor lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] decreases reaction
/ increases expression
protein 22429818
C015329 196 AHR
bHLHe76
aryl hydrocarbon receptor lycopene results in decreased expression of AHR mRNA decreases expression
mRNA 16886892
C015329 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) lycopene results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 17337101
C015329 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor lycopene results in decreased expression of AR mRNA decreases expression
mRNA 16886892
C015329 571 BACH1
BACH-1
BTB and CNC homology 1, basic leucine zipper transcription factor 1 lycopene results in increased expression of BACH1 mRNA increases expression
mRNA 16886892
C015329 8314 BAP1
HUCEP-13
UCHL2
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (EC:3.4.19.12) lycopene results in increased expression of BAP1 mRNA increases expression
mRNA 16886892
C015329 673 BRAF
B-RAF1
BRAF1
NS7
RAFB1
v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) lycopene results in decreased expression of BRAF protein decreases expression
protein 17337101
C015329 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) lycopene results in decreased expression of CASP8 mRNA decreases expression
mRNA 16886892
C015329 847 CAT
catalase (EC:1.11.1.6) lycopene results in increased expression of CAT increases expression
19450652
C015329 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 lycopene inhibits the reaction [Genistein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 17051425
C015329 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 lycopene inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 16565789
C015329 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 lycopene results in decreased expression of CCND1 protein decreases expression
protein 17337101
C015329 898 CCNE1
CCNE
cyclin E1 lycopene results in decreased expression of CCNE1 protein decreases expression
protein 17337101
C015329 898 CCNE1
CCNE
cyclin E1 lycopene results in increased expression of CCNE1 mRNA increases expression
mRNA 16886892
C015329 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) lycopene results in decreased expression of CDK1 protein decreases expression
protein 17337101
C015329 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) lycopene results in decreased expression of CDK4 protein decreases expression
protein 17337101
C015329 1020 CDK5
PSSALRE
cyclin-dependent kinase 5 (EC:2.7.11.22) lycopene results in decreased expression of CDK5 protein decreases expression
protein 17337101
C015329 1022 CDK7
CAK1
CDKN7
HCAK
MO15
STK1
p39MO15
cyclin-dependent kinase 7 (EC:2.7.11.23 2.7.11.22) lycopene results in decreased expression of CDK7 protein decreases expression
protein 17337101
C015329 1025 CDK9
C-2k
CDC2L4
CTK1
PITALRE
TAK
cyclin-dependent kinase 9 (EC:2.7.11.23 2.7.11.22) lycopene results in decreased expression of CDK9 protein decreases expression
protein 17337101
C015329 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) lycopene inhibits the reaction [IGF1 protein results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16565789
C015329 1113 CHGA
CGA
chromogranin A (parathyroid secretory protein 1) lycopene results in increased expression of CHGA mRNA increases expression
mRNA 16886892
C015329 1114 CHGB
SCG1
chromogranin B (secretogranin 1) lycopene results in decreased expression of CHGB mRNA decreases expression
mRNA 16886892
C015329 23418 CRB1
LCA8
RP12
crumbs homolog 1 (Drosophila) lycopene results in decreased expression of CRB1 mRNA decreases expression
mRNA 16886892
C015329 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) lycopene results in increased activity of CYP3A4 protein increases activity
protein 16632523
C015329 1643 DDB2
DDBB
UV-DDB2
damage-specific DNA binding protein 2, 48kDa lycopene results in increased expression of DDB2 mRNA increases expression
mRNA 16886892
C015329 1981 EIF4G1
EIF-4G1
EIF4F
EIF4G
EIF4GI
P220
PARK18
eukaryotic translation initiation factor 4 gamma, 1 lycopene results in increased expression of EIF4G1 mRNA increases expression
mRNA 16886892
C015329 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 lycopene inhibits the reaction [Estradiol results in increased activity of ESR1 protein] decreases reaction
/ increases activity
protein 17051425
C015329 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 lycopene results in increased expression of ESR1 mRNA increases expression
mRNA 16886892
C015329 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) lycopene inhibits the reaction [Estradiol results in increased activity of ESR2 protein] decreases reaction
/ increases activity
protein 17051425
C015329 2176 FANCC
FA3
FAC
FACC
Fanconi anemia, complementation group C lycopene results in decreased expression of FANCC mRNA decreases expression
mRNA 16886892
C015329 2188 FANCF
FAF
Fanconi anemia, complementation group F lycopene results in decreased expression of FANCF mRNA decreases expression
mRNA 16886892
C015329 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) lycopene results in decreased expression of FASLG mRNA decreases expression
mRNA 16886892
C015329 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog lycopene results in increased expression of FOS mRNA increases expression
mRNA 16886892
C015329 2701 GJA4
CX37
gap junction protein, alpha 4, 37kDa lycopene results in decreased expression of GJA4 mRNA decreases expression
mRNA 16886892
C015329 2702 GJA5
ATFB11
CX40
gap junction protein, alpha 5, 40kDa lycopene results in decreased expression of GJA5 mRNA decreases expression
mRNA 16886892
C015329 2702 GJA5
ATFB11
CX40
gap junction protein, alpha 5, 40kDa lycopene results in increased expression of GJA5 mRNA increases expression
mRNA 16886892
C015329 2879 GPX4
GPx-4
GSHPx-4
MCSP
PHGPx
snGPx
snPHGPx
glutathione peroxidase 4 (EC:1.11.1.12) lycopene results in decreased expression of GPX4 mRNA decreases expression
mRNA 16886892
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of PLA2G2A protein] decreases reaction
/ increases expression
/ increases secretion
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of TNF protein] decreases reaction
/ increases expression
/ increases secretion
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein] decreases reaction
/ increases secretion
protein 22429818
C015329 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 lycopene results in decreased susceptibility to HMGB1 protein decreases response to substance
protein 22429818
C015329 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 22429818
C015329 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22429818
C015329 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) lycopene inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 16565789
C015329 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) lycopene inhibits the reaction [IGF1 protein results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16565789
C015329 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) lycopene inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein] decreases reaction
/ increases phosphorylation
protein 16565789
C015329 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) lycopene results in decreased expression of IGF1 mRNA decreases expression
mRNA 16886892
C015329 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) lycopene results in increased expression of IGF1 mRNA increases expression
mRNA 16886892
C015329 3480 IGF1R
CD221
IGFIR
IGFR
JTK13
insulin-like growth factor 1 receptor (EC:2.7.10.1) lycopene results in decreased expression of IGF1R protein decreases expression
protein 17337101
C015329 3485 IGFBP2
IBP2
IGF-BP53
insulin-like growth factor binding protein 2, 36kDa lycopene results in increased expression of IGFBP2 protein increases expression
protein 17337101
C015329 3713 IVL
involucrin lycopene results in decreased expression of IVL protein decreases expression
protein 10769631
C015329 3716 JAK1
JAK1A
JAK1B
JTK3
Janus kinase 1 (EC:2.7.10.2) lycopene results in increased expression of JAK1 mRNA increases expression
mRNA 16886892
C015329 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene lycopene results in decreased expression of JUN mRNA decreases expression
mRNA 16886892
C015329 3796 KIF2A
CDCBM3
HK2
KIF2
kinesin heavy chain member 2A lycopene results in increased expression of KIF2A mRNA increases expression
mRNA 16886892
C015329 3838 KPNA2
IPOA1
QIP2
RCH1
SRP1alpha
karyopherin alpha 2 (RAG cohort 1, importin alpha 1) lycopene results in increased expression of KPNA2 mRNA increases expression
mRNA 16886892
C015329 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor lycopene results in increased expression of LDLR mRNA increases expression
mRNA 16886892
C015329 3988 LIPA
CESD
LAL
lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13) lycopene results in increased expression of LIPA mRNA increases expression
mRNA 16886892
C015329 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) lycopene results in increased expression of MAP2K1 mRNA increases expression
mRNA 16886892
C015329 5605 MAP2K2
CFC4
MAPKK2
MEK2
MKK2
PRKMK2
mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) lycopene results in decreased expression of MAP2K2 protein decreases expression
protein 17337101
C015329 6416 MAP2K4
JNKK
JNKK1
MAPKK4
MEK4
MKK4
PRKMK4
SAPKK-1
SAPKK1
SEK1
SERK1
SKK1
mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) lycopene results in decreased expression of MAP2K4 protein decreases expression
protein 17337101
C015329 5608 MAP2K6
MAPKK6
MEK6
MKK6
PRKMK6
SAPKK-3
SAPKK3
mitogen-activated protein kinase kinase 6 (EC:2.7.12.2) lycopene results in decreased expression of MAP2K6 protein decreases expression
protein 17337101
C015329 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) lycopene results in decreased expression of MAPK14 protein decreases expression
protein 17337101
C015329 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) lycopene results in increased expression of MAPK14 mRNA increases expression
mRNA 16886892
C015329 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) lycopene results in decreased expression of MAPK3 protein decreases expression
protein 17337101
C015329 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) lycopene results in decreased expression of MAPK8 protein decreases expression
protein 17337101
C015329 4247 MGAT2
CDG2A
CDGS2
GLCNACTII
GNT-II
GNT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143) lycopene results in increased expression of MGAT2 mRNA increases expression
mRNA 16886892
C015329 100507436 MICA
MIC-A
PERB11.1
MHC class I polypeptide-related sequence A lycopene results in increased expression of MICA mRNA increases expression
mRNA 16886892
C015329 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 lycopene results in increased expression of MLH1 mRNA increases expression
mRNA 16886892
C015329 4436 MSH2
COCA1
FCC1
HNPCC
HNPCC1
LCFS2
mutS homolog 2 lycopene results in increased expression of MSH2 mRNA increases expression
mRNA 16886892
C015329 2956 MSH6
GTBP
GTMBP
HNPCC5
HSAP
p160
mutS homolog 6 lycopene results in increased expression of MSH6 mRNA increases expression
mRNA 16886892
C015329 4842 NOS1
IHPS1
N-NOS
NC-NOS
NOS
bNOS
nNOS
nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) lycopene results in decreased expression of NOS1 mRNA decreases expression
mRNA 16886892
C015329 8021 NUP214
CAIN
CAN
D9S46E
N214
p250
nucleoporin 214kDa lycopene results in decreased expression of NUP214 mRNA decreases expression
mRNA 16886892
C015329 5320 PLA2G2A
MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of PLA2G2A protein] decreases reaction
/ increases expression
/ increases secretion
protein 22429818
C015329 5591 PRKDC
DNA-PKcs
DNAPK
DNPK1
HYRC
HYRC1
XRCC7
p350
protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) lycopene results in decreased expression of PRKDC mRNA decreases expression
mRNA 16886892
C015329 10111 RAD50
NBSLD
RAD502
hRad50
RAD50 homolog (S. cerevisiae) lycopene results in increased expression of RAD50 mRNA increases expression
mRNA 16886892
C015329 8045 RASSF7
C11orf13
HRAS1
HRC1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 lycopene results in increased expression of RASSF7 mRNA increases expression
mRNA 16886892
C015329 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 lycopene inhibits the reaction [Genistein results in increased phosphorylation of and results in decreased activity of RB1 protein] decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17051425
C015329 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 lycopene inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein] decreases reaction
/ increases phosphorylation
protein 16565789
C015329 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 lycopene results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 17337101
C015329 5962 RDX
DFNB24
radixin lycopene results in decreased expression of RDX mRNA decreases expression
mRNA 16886892
C015329 6195 RPS6KA1
HU-1
MAPKAPK1A
RSK
RSK1
ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) lycopene results in decreased expression of RPS6KA1 protein decreases expression
protein 17337101
C015329 6197 RPS6KA3
CLS
HU-3
ISPK-1
MAPKAPK1B
MRX19
RSK
RSK2
S6K-alpha3
p90-RSK2
pp90RSK2
ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) lycopene results in decreased expression of RPS6KA3 protein decreases expression
protein 17337101
C015329 6241 RRM2
R2
RR2
RR2M
ribonucleotide reductase M2 (EC:1.17.4.1) lycopene results in increased expression of RRM2 mRNA increases expression
mRNA 16886892
C015329 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
mRNA 22429818
C015329 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 22429818
C015329 6414 SEPP1
SELP
SeP
selenoprotein P, plasma, 1 lycopene results in decreased expression of SEPP1 mRNA decreases expression
mRNA 16886892
C015329 4088 SMAD3
HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
SMAD family member 3 lycopene results in increased expression of SMAD3 mRNA increases expression
mRNA 16886892
C015329 8243 SMC1A
CDLS2
DXS423E
SB1.8
SMC1
SMC1L1
SMC1alpha
SMCB
structural maintenance of chromosomes 1A lycopene results in decreased expression of SMC1A mRNA decreases expression
mRNA 16886892
C015329 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) lycopene results in increased expression of STAT3 mRNA increases expression
mRNA 16886892
C015329 7031 TFF1
BCEI
D21S21
HP1.A
HPS2
pNR-2
pS2
trefoil factor 1 lycopene results in decreased expression of TFF1 mRNA decreases expression
mRNA 16886892
C015329 7980 TFPI2
PP5
REF1
TFPI-2
tissue factor pathway inhibitor 2 lycopene results in decreased expression of TFPI2 mRNA decreases expression
mRNA 16886892
C015329 7039 TGFA
TFGA
transforming growth factor, alpha lycopene results in increased expression of TGFA mRNA increases expression
mRNA 16886892
C015329 7097 TLR2
CD282
TIL4
toll-like receptor 2 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein] decreases reaction
/ increases expression
protein 22429818
C015329 7097 TLR2
CD282
TIL4
toll-like receptor 2 lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein] decreases reaction
/ increases expression
protein 22429818
C015329 7099 TLR4
ARMD10
CD284
TLR-4
TOLL
toll-like receptor 4 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein] decreases reaction
/ increases expression
protein 22429818
C015329 7099 TLR4
ARMD10
CD284
TLR-4
TOLL
toll-like receptor 4 lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] decreases reaction
/ increases expression
protein 22429818
C015329 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of TNF protein] decreases reaction
/ increases expression
/ increases secretion
protein 22429818
C015329 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 lycopene results in decreased expression of TP53 mRNA decreases expression
mRNA 16886892
C015329 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 22429818
C015329 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 22429818
C015329 7415 VCP
ALS14
IBMPFD
IBMPFD1
TERA
p97
valosin containing protein (EC:3.6.4.6) lycopene results in increased expression of VCP mRNA increases expression
mRNA 16886892
C015329 7485 WRB
CHD5
tryptophan rich basic protein lycopene results in decreased expression of WRB mRNA decreases expression
mRNA 16886892
C015329 7697 ZNF138
pHZ-32
zinc finger protein 138 lycopene results in increased expression of ZNF138 mRNA increases expression
mRNA 16886892

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#275210 Restrictive dermopathy, lethal P02545
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (13)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)

Diseases related to CTD interactions

13 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D056486 C015329 Drug-Induced Liver Injury therapeutic
22192907
D006943 C015329 Hyperglycemia therapeutic
22192907
D006965 C015329 Hyperplasia therapeutic
19329757
D007248 C015329 Infertility, Male therapeutic
19071209
20074268
D007249 C015329 Inflammation therapeutic
22429818
D007674 C015329 Kidney Diseases therapeutic
22108423
D009369 C015329 Neoplasms therapeutic
17051425
22429818
D020258 C015329 Neurotoxicity Syndromes therapeutic
22192907
D011471 C015329 Prostatic Neoplasms therapeutic
15084515
17337101
D012878 C015329 Skin Neoplasms therapeutic
19329757
D013733 C015329 Testicular Diseases therapeutic
20074268
D014178 C015329 Translocation, Genetic therapeutic
19450652
D015431 C015329 Weight Loss therapeutic
17873360