PCIDB

KNApSAcK Metabolite C00000938

Metabolite

KNApSAcK Entry

id C00000938
Name Ampelopsin / Dihydromyricetin / (2R,3R)-3,5,7,3',4',5'-Hexahydroxyflavanone
CAS RN 27200-12-0
Standard InChI InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 42

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL2048508

KEGG

By LinkDB C02906

CTD

By CAS RN C106407

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P39900 Macrophage metalloelastase M10A CHEMBL2048508 CHEMBL2051216 (1) CHEMBL2051222 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL2048508 CHEMBL2051215 (1) CHEMBL2051221 (1)
2 / 2
P03956 Interstitial collagenase M10A CHEMBL2048508 CHEMBL2051212 (1)
0 / 1
P45452 Collagenase 3 M10A CHEMBL2048508 CHEMBL2051217 (1) CHEMBL2051223 (1)
1 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL2048508 CHEMBL2051213 (1) CHEMBL2051219 (1)
1 / 3
P08254 Stromelysin-1 M10A CHEMBL2048508 CHEMBL2051214 (1) CHEMBL2051220 (1)
1 / 0

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C106407 8877 SPHK1
SPHK
sphingosine kinase 1 (EC:2.7.1.91) ampelopsin results in decreased activity of SPHK1 protein decreases activity
protein 22251058
C106407 8877 SPHK1
SPHK
sphingosine kinase 1 (EC:2.7.1.91) ampelopsin results in decreased expression of SPHK1 protein decreases expression
protein 22251058

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452

KEGG DISEASE (4)

KEGG disease name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)