KNApSAcK Metabolite C00009380
Metabolite
KNApSAcK Entry
| id | C00009380 |
|---|---|
| Name | Daidzein / 7,4'-Dihydroxyisoflavone |
| CAS RN | 486-66-8 |
| Standard InChI | InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H |
| Standard InChI (Main Layer) | InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H |
Cluster
| Phytochemical cluster | No. 15 |
|---|---|
| KCF-S cluster | No. 71 |
Link
ChEMBL
| By standard InChI | CHEMBL8145 |
|---|---|
| By standard InChI Main Layer | CHEMBL8145 |
KEGG
| By LinkDB | C10208 |
|---|
CTD
| By CAS RN | C004742 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 27 |
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Fabaceae | 26 |
| Podocarpaceae | 1 |
| Brassicaceae | 1 |
| Streptomycetaceae | 1 |
List (29)
* NCBI
Human Protein / Gene in interaction
60 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL8145 |
CHEMBL1614110
(1)
CHEMBL1741321
(1)
|
1 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | CHEMBL8145 |
CHEMBL957998
(1)
CHEMBL957999
(1)
|
0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | CHEMBL8145 |
CHEMBL2078146
(1)
|
0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | CHEMBL8145 |
CHEMBL816283
(1)
|
3 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL8145 |
CHEMBL1613992
(2)
CHEMBL1613995
(1)
|
7 / 44 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL8145 |
CHEMBL1613842
(4)
|
4 / 2 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | CHEMBL8145 |
CHEMBL2169429
(1)
|
1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | CHEMBL8145 |
CHEMBL2169431
(1)
|
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL8145 |
CHEMBL1794367
(1)
|
1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL8145 |
CHEMBL1794499
(1)
|
2 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | CHEMBL8145 |
CHEMBL1614177
(1)
CHEMBL1614265
(1)
|
0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL8145 |
CHEMBL1794552
(1)
CHEMBL2341203
(1)
CHEMBL2341207 (1) |
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL8145 |
CHEMBL1614544
(1)
|
11 / 10 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | CHEMBL8145 |
CHEMBL991725
(1)
CHEMBL990777
(1)
|
1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL8145 |
CHEMBL1794399
(1)
|
3 / 1 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | CHEMBL8145 |
CHEMBL641008
(1)
CHEMBL641141
(1)
CHEMBL693590 (1) CHEMBL693591 (1) CHEMBL693592 (1) CHEMBL693593 (1) |
1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL8145 |
CHEMBL1614027
(1)
CHEMBL1741325
(1)
|
0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL8145 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL8145 |
CHEMBL941404
(1)
|
1 / 11 |
| P11387 | DNA topoisomerase 1 | Isomerase | CHEMBL8145 |
CHEMBL873578
(1)
|
0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | CHEMBL8145 |
CHEMBL1014691
(1)
|
0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | CHEMBL8145 |
CHEMBL926465
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL8145 |
CHEMBL1614458
(7)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL8145 |
CHEMBL2114843
(1)
|
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL8145 |
CHEMBL1613838
(1)
|
0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | CHEMBL8145 |
CHEMBL926467
(1)
|
0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL8145 |
CHEMBL682168
(1)
CHEMBL677051
(1)
CHEMBL677223 (1) CHEMBL708330 (1) CHEMBL708331 (1) CHEMBL826030 (1) CHEMBL828540 (2) CHEMBL830453 (2) CHEMBL1008128 (1) |
0 / 1 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | CHEMBL8145 |
CHEMBL2169430
(1)
|
1 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | CHEMBL8145 |
CHEMBL1794423
(1)
CHEMBL1963893
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL8145 |
CHEMBL1052488
(1)
CHEMBL1052489
(1)
CHEMBL1794382 (1) |
0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | CHEMBL8145 |
CHEMBL987972
(1)
|
2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL8145 |
CHEMBL1059360
(1)
CHEMBL1059361
(1)
|
5 / 3 |
| P04745 | Alpha-amylase 1 | Enzyme | CHEMBL8145 |
CHEMBL964479
(2)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL8145 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL8145 |
CHEMBL1613910
(2)
CHEMBL1614227
(3)
|
3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | CHEMBL8145 |
CHEMBL2076827
(1)
CHEMBL2076841
(1)
|
2 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL8145 |
CHEMBL1614038
(4)
|
2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL8145 |
CHEMBL1614342
(1)
|
1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | CHEMBL8145 |
CHEMBL1614171
(1)
|
5 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL8145 |
CHEMBL2114842
(1)
|
0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL8145 |
CHEMBL1738675
(1)
CHEMBL1737868
(1)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL8145 |
CHEMBL676818
(1)
CHEMBL679893
(1)
CHEMBL682303 (1) CHEMBL708330 (1) CHEMBL708331 (1) CHEMBL826030 (1) CHEMBL832956 (2) CHEMBL830453 (2) CHEMBL946607 (1) CHEMBL999946 (1) CHEMBL999947 (1) CHEMBL1219553 (1) CHEMBL1219557 (1) CHEMBL1219559 (1) CHEMBL1219560 (1) CHEMBL1794364 (2) CHEMBL1794542 (2) |
1 / 1 |
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL8145 |
CHEMBL926466
(1)
|
0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL8145 |
CHEMBL1614274
(1)
CHEMBL1613823
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL8145 |
CHEMBL1613777
(1)
CHEMBL1741323
(1)
|
1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | CHEMBL8145 |
CHEMBL958788
(1)
CHEMBL958789
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL8145 |
CHEMBL1614108
(2)
CHEMBL1613886
(2)
CHEMBL1741324 (1) |
0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL8145 |
CHEMBL1614211
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL8145 |
CHEMBL1614421
(2)
|
4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL8145 |
CHEMBL1737980
(1)
CHEMBL2114890
(2)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL8145 |
CHEMBL1052486
(1)
CHEMBL1052498
(1)
CHEMBL1794321 (2) CHEMBL1794560 (1) |
3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | CHEMBL8145 |
CHEMBL1059364
(1)
CHEMBL1059365
(1)
|
0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | CHEMBL8145 |
CHEMBL2114849
(2)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL8145 |
CHEMBL1613914
(4)
|
0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | CHEMBL8145 |
CHEMBL1614086
(1)
CHEMBL1614034
(1)
|
1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL8145 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL8145 |
CHEMBL1614364
(1)
|
1 / 1 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | CHEMBL8145 |
CHEMBL879881
(1)
CHEMBL689869
(1)
CHEMBL689870 (1) CHEMBL731143 (1) CHEMBL731145 (1) |
0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL8145 |
CHEMBL879881
(1)
CHEMBL689869
(1)
CHEMBL689870 (1) CHEMBL731143 (1) CHEMBL731145 (1) |
1 / 1 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | CHEMBL8145 |
CHEMBL2114881
(1)
|
0 / 0 |
CTD interaction (191)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C004742 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| C004742 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | daidzein inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP] |
decreases reaction
/ increases export |
protein |
16156793
|
| C004742 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| C004742 | 10057 |
ABCC5
ABC33 EST277145 MOAT-C MOATC MRP5 SMRP pABC11 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | daidzein inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] |
decreases reaction
/ decreases response to substance |
protein |
16156793
|
| C004742 | 10057 |
ABCC5
ABC33 EST277145 MOAT-C MOATC MRP5 SMRP pABC11 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
decreases reaction
/ increases export |
protein |
16156793
|
| C004742 | 119 |
ADD2
ADDB |
adducin 2 (beta) | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | daidzein binds to AHR protein |
affects binding
|
protein |
20436506
|
| C004742 | 249 |
ALPL
AP-TNAP APTNAP HOPS TNAP TNSALP |
alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) | [daidzein binds to ESR1 protein] which results in increased activity of ALPL protein |
affects binding
/ increases activity |
protein |
12650720
|
| C004742 | 249 |
ALPL
AP-TNAP APTNAP HOPS TNAP TNSALP |
alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) | fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein] |
affects binding
/ decreases reaction / increases activity |
protein |
12650720
|
| C004742 | 251 |
ALPPL2
ALPG ALPPL GCAP |
alkaline phosphatase, placental-like 2 (EC:3.1.3.1) | daidzein metabolite results in increased expression of ALPPL2 mRNA |
increases expression
|
mRNA |
15993745
|
| C004742 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | daidzein promotes the reaction [TGFB1I1 protein results in increased activity of AR protein] |
increases activity
/ increases reaction |
protein |
17252558
|
| C004742 | 396 |
ARHGDIA
GDIA1 NPHS8 RHOGDI RHOGDI-1 |
Rho GDP dissociation inhibitor (GDI) alpha | daidzein results in decreased expression of ARHGDIA mRNA |
decreases expression
|
mRNA |
15757668
|
| C004742 | 23545 |
ATP6V0A2
A2 ARCL ARCL2A ATP6A2 ATP6N1D J6B7 RTF STV1 TJ6 TJ6M TJ6S VPH1 WSS |
ATPase, H+ transporting, lysosomal V0 subunit a2 (EC:3.6.3.6) | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ATP6V0A2 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 11177 |
BAZ1A
ACF1 WALp1 WCRF180 hACF1 |
bromodomain adjacent to zinc finger domain, 1A | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | daidzein results in decreased expression of BCL2 protein |
decreases expression
|
protein |
12791511
|
| C004742 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | daidzein results in decreased expression of BCL2L1 protein |
decreases expression
|
protein |
12791511
|
| C004742 | 632 |
BGLAP
BGP OC OCN |
bone gamma-carboxyglutamate (gla) protein | [daidzein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA |
affects cotreatment
/ increases expression |
mRNA |
19347870
|
| C004742 | 632 |
BGLAP
BGP OC OCN |
bone gamma-carboxyglutamate (gla) protein | [daidzein co-treated with ESR2 protein] results in increased expression of BGLAP mRNA |
affects cotreatment
/ increases expression |
mRNA |
19347870
|
| C004742 | 672 |
BRCA1
BRCAI BRCC1 BROVCA1 IRIS PNCA4 PPP1R53 PSCP RNF53 |
breast cancer 1, early onset | daidzein results in increased expression of BRCA1 mRNA |
increases expression
|
mRNA |
17266178
|
| C004742 | 103993 | [daidzein co-treated with ESR1 protein] results in increased expression of BSP mRNA |
affects cotreatment
/ increases expression |
mRNA |
19347870
|
||
| C004742 | 103993 | [daidzein co-treated with ESR2 protein] results in increased expression of BSP mRNA |
affects cotreatment
/ increases expression |
mRNA |
19347870
|
||
| C004742 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | daidzein results in increased activity of CASP3 protein |
increases activity
|
protein |
12791511
|
| C004742 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | daidzein results in decreased expression of CCNA2 |
decreases expression
|
21161820
|
|
| C004742 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | daidzein results in increased expression of CCND1 mRNA |
increases expression
|
mRNA |
17266178
19800779 |
| C004742 | 1017 |
CDK2
p33(CDK2) |
cyclin-dependent kinase 2 (EC:2.7.11.22) | daidzein promotes the reaction [CDKN1A protein binds to CDK2 protein] |
affects binding
/ increases reaction |
protein |
11322924
|
| C004742 | 1017 |
CDK2
p33(CDK2) |
cyclin-dependent kinase 2 (EC:2.7.11.22) | daidzein results in decreased activity of CDK2 protein |
decreases activity
|
protein |
11322924
|
| C004742 | 1019 |
CDK4
CMM3 PSK-J3 |
cyclin-dependent kinase 4 (EC:2.7.11.22) | daidzein results in decreased activity of CDK4 protein |
decreases activity
|
protein |
21161820
|
| C004742 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | daidzein promotes the reaction [CDKN1A protein binds to CDK2 protein] |
affects binding
/ increases reaction |
protein |
11322924
|
| C004742 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | daidzein results in increased expression of CDKN1A |
increases expression
|
21161820
|
|
| C004742 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | ESR2 affects the reaction [daidzein results in increased expression of CDKN1A] |
affects reaction
/ increases expression |
21161820
|
|
| C004742 | 1103 |
CHAT
CHOACTASE CMS1A CMS1A2 |
choline O-acetyltransferase (EC:2.3.1.6) | daidzein results in increased activity of CHAT protein |
increases activity
|
protein |
16428827
|
| C004742 | 1152 |
CKB
B-CK CKBB |
creatine kinase, brain (EC:2.7.3.2) | daidzein results in increased activity of CKB protein |
increases activity
|
protein |
16621514
|
| C004742 | 1152 |
CKB
B-CK CKBB |
creatine kinase, brain (EC:2.7.3.2) | Glucose inhibits the reaction [daidzein results in increased activity of CKB protein] |
decreases reaction
/ increases activity |
protein |
16621514
|
| C004742 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] |
decreases reaction
/ increases methylation |
protein |
18192686
|
| C004742 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | daidzein results in decreased activity of COMT protein |
decreases activity
|
protein |
18192686
18497090 |
| C004742 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | daidzein results in decreased expression of COMT mRNA |
decreases expression
|
mRNA |
18192686
18497090 |
| C004742 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA] |
decreases expression
/ decreases reaction |
mRNA |
18192686
18497090 |
| C004742 | 9167 |
COX7A2L
COX7AR COX7RP EB1 SIG81 |
cytochrome c oxidase subunit VIIa polypeptide 2 like | daidzein results in increased expression of COX7A2L mRNA |
increases expression
|
mRNA |
17266178
|
| C004742 | 1374 |
CPT1A
CPT1 CPT1-L L-CPT1 |
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) | daidzein results in increased expression of CPT1A mRNA |
increases expression
|
mRNA |
16362726
|
| C004742 | 1374 |
CPT1A
CPT1 CPT1-L L-CPT1 |
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) | daidzein results in increased expression of CPT1A protein |
increases expression
|
protein |
16362726
|
| C004742 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | [Genistein co-treated with daidzein] results in decreased expression of CRP protein |
affects cotreatment
/ decreases expression |
protein |
16332659
|
| C004742 | 6387 |
CXCL12
IRH PBSF SCYB12 SDF1 TLSF TPAR1 SDF1A SDF1B |
chemokine (C-X-C motif) ligand 12 | daidzein results in increased expression of CXCL12 mRNA |
increases expression
|
mRNA |
23384675
|
| C004742 | 6387 |
CXCL12
IRH PBSF SCYB12 SDF1 TLSF TPAR1 SDF1A SDF1B |
chemokine (C-X-C motif) ligand 12 | ESR1 protein inhibits the reaction [daidzein results in increased expression of CXCL12 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C004742 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | daidzein results in decreased activity of CYP19A1 protein |
decreases activity
|
protein |
16023337
16965912 |
| C004742 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | daidzein results in decreased expression of CYP19A1 mRNA |
decreases expression
|
mRNA |
16965912
|
| C004742 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein |
affects cotreatment
/ decreases activity |
protein |
16965912
|
| C004742 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16965912
|
| C004742 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | daidzein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
18451504
|
| C004742 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | daidzein results in decreased activity of CYP1A1 protein |
decreases activity
|
protein |
18497090
|
| C004742 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | daidzein results in decreased expression of CYP1A1 mRNA |
decreases expression
|
mRNA |
18451504
18497090 |
| C004742 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | CYP1B1 protein affects the chemical synthesis of daidzein |
affects chemical synthesis
|
protein |
15479032
|
| C004742 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | daidzein results in decreased activity of CYP1B1 protein |
decreases activity
|
protein |
15479032
|
| C004742 | 1589 |
CYP21A2
CA21H CAH1 CPS1 CYP21 CYP21B P450c21B |
cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) | daidzein inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23370353
|
| C004742 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | daidzein results in decreased activity of CYP2C9 protein |
decreases activity
|
protein |
18420780
|
| C004742 | 1565 |
CYP2D6
CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | daidzein results in decreased activity of CYP2D6 protein |
decreases activity
|
protein |
18420780
|
| C004742 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | daidzein results in decreased activity of CYP3A4 protein |
decreases activity
|
protein |
18420780
|
| C004742 | 1795 |
DOCK3
MOCA PBP |
dedicator of cytokinesis 3 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 1846 |
DUSP4
HVH2 MKP-2 MKP2 TYP |
dual specificity phosphatase 4 (EC:3.1.3.16 3.1.3.48) | daidzein results in decreased expression of DUSP4 mRNA |
decreases expression
|
mRNA |
16865672
|
| C004742 | 9166 |
EBAG9
EB9 PDAF |
estrogen receptor binding site associated, antigen, 9 | daidzein results in increased expression of EBAG9 mRNA |
increases expression
|
mRNA |
17266178
|
| C004742 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19347870
|
| C004742 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR protein |
affects cotreatment
/ decreases expression |
protein |
19347870
|
| C004742 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | [daidzein co-treated with ESR2 protein] results in decreased expression of EGFR mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19347870
|
| C004742 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | [daidzein co-treated with ESR2 protein] results in decreased expression of EGFR protein |
affects cotreatment
/ decreases expression |
protein |
19347870
|
| C004742 | 2027 |
ENO3
GSD13 MSE |
enolase 3 (beta, muscle) (EC:4.2.1.11) | daidzein results in decreased expression of ENO3 mRNA |
decreases expression
|
mRNA |
15757668
|
| C004742 | 2041 |
EPHA1
EPH EPHT EPHT1 |
EPH receptor A1 (EC:2.7.10.1) | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 83715 |
ESPN
DFNB36 |
espin | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ESPN mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein binds to and results in increased activity of ESR1 protein |
affects binding
/ increases activity |
protein |
9751507
15876408 16076101 |
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein binds to ESR1 protein |
affects binding
|
protein |
12598185
14579009 16506809 16773531 18692112 19913605 |
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | [daidzein binds to ESR1 protein] which results in increased activity of ALPL protein |
affects binding
/ increases activity |
protein |
12650720
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA |
affects cotreatment
/ decreases expression |
protein |
19347870
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR protein |
affects cotreatment
/ decreases expression |
protein |
19347870
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | [daidzein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA |
affects cotreatment
/ increases expression |
protein |
19347870
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | [daidzein co-treated with ESR1 protein] results in increased expression of BSP mRNA |
affects cotreatment
/ increases expression |
protein |
19347870
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein inhibits the reaction [Estradiol binds to ESR1 protein] |
affects binding
/ decreases reaction |
protein |
14579009
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein metabolite binds to and results in increased activity of ESR1 protein |
affects binding
/ increases activity |
protein |
15084758
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein metabolite promotes the reaction [NCOA2 protein binds to ESR1 protein] |
affects binding
/ increases reaction |
protein |
15084758
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein promotes the reaction [Estradiol results in increased activity of ESR1 protein] |
increases activity
/ increases reaction |
protein |
16118406
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein results in decreased expression of ESR1 mRNA |
decreases expression
|
mRNA |
16033089
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein results in decreased expression of ESR1 protein |
decreases expression
|
protein |
16033089
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | daidzein results in increased activity of ESR1 protein |
increases activity
|
protein |
16118406
19161236 |
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of CXCL12 mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of GREB1 mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of PGR mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of PRSS23 mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
protein |
23384675
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | Estradiol affects the reaction [daidzein metabolite affects the activity of ESR1 protein] |
affects activity
/ affects reaction |
protein |
16965913
|
| C004742 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein] |
affects binding
/ decreases reaction / increases activity |
protein |
12650720
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein binds to and results in increased activity of ESR2 protein |
affects binding
/ increases activity |
protein |
9751507
16076101 |
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein binds to ESR2 protein |
affects binding
|
protein |
12224631
15993745 16506809 16566672 16773531 19913605 |
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | [daidzein co-treated with ESR2 protein] results in decreased expression of EGFR mRNA |
affects cotreatment
/ decreases expression |
protein |
19347870
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | [daidzein co-treated with ESR2 protein] results in decreased expression of EGFR protein |
affects cotreatment
/ decreases expression |
protein |
19347870
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | [daidzein co-treated with ESR2 protein] results in increased expression of BGLAP mRNA |
affects cotreatment
/ increases expression |
protein |
19347870
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | [daidzein co-treated with ESR2 protein] results in increased expression of BSP mRNA |
affects cotreatment
/ increases expression |
protein |
19347870
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | [daidzein co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA |
affects cotreatment
/ increases expression |
protein |
19347870
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein inhibits the reaction [Estradiol binds to ESR2 protein] |
affects binding
/ decreases reaction |
protein |
16566672
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein metabolite binds to and results in increased activity of ESR2 protein |
affects binding
/ increases activity |
protein |
15084758
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein promotes the reaction [Estradiol results in increased activity of ESR2 protein] |
increases activity
/ increases reaction |
protein |
16118406
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein results in increased activity of ESR2 protein |
increases activity
|
protein |
16118406
18937077 19161236 |
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein results in increased activity of ESR2 protein alternative form |
increases activity
|
protein |
17266178
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein results in increased expression of ESR2 mRNA |
increases expression
|
mRNA |
16033089
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | daidzein results in increased expression of ESR2 protein |
increases expression
|
protein |
16033089
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | ESR2 affects the reaction [daidzein results in increased expression of CDKN1A] |
affects reaction
/ increases expression |
21161820
|
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | ESR2 affects the susceptibility to daidzein |
affects response to substance
|
21161820
|
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | ESR2 gene polymorphism affects the reaction [[Genistein co-treated with daidzein] affects the expression of VCAM1 protein] |
affects cotreatment
/ affects expression / affects reaction |
gene |
16332659
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | ESR2 gene polymorphism affects the susceptibility to [Genistein co-treated with daidzein] |
affects cotreatment
/ affects response to substance |
gene |
16332659
|
| C004742 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | Estradiol affects the reaction [daidzein metabolite affects the activity of ESR2 protein] |
affects activity
/ affects reaction |
protein |
16965913
|
| C004742 | 2101 |
ESRRA
ERR1 ERRa ERRalpha ESRL1 NR3B1 |
estrogen-related receptor alpha | daidzein binds to and results in increased activity of ESRRA protein |
affects binding
/ increases activity |
protein |
14638870
|
| C004742 | 2101 |
ESRRA
ERR1 ERRa ERRalpha ESRL1 NR3B1 |
estrogen-related receptor alpha | daidzein binds to and results in increased activity of ESRRA protein mutant form |
affects binding
/ increases activity |
protein |
14638870
|
| C004742 | 2101 |
ESRRA
ERR1 ERRa ERRalpha ESRL1 NR3B1 |
estrogen-related receptor alpha | daidzein promotes the reaction [ESRRA protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004742 | 2103 |
ESRRB
DFNB35 ERR2 ERRb ESRL2 NR3B2 |
estrogen-related receptor beta | daidzein binds to and results in increased activity of ESRRB protein |
affects binding
/ increases activity |
protein |
14638870
|
| C004742 | 2103 |
ESRRB
DFNB35 ERR2 ERRb ESRL2 NR3B2 |
estrogen-related receptor beta | daidzein promotes the reaction [ESRRB protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004742 | 2104 |
ESRRG
ERR3 ERRgamma NR3B3 |
estrogen-related receptor gamma | daidzein promotes the reaction [ESRRG protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004742 | 56776 |
FMN2
|
formin 2 | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | daidzein results in increased expression of FOS mRNA |
increases expression
|
mRNA |
17142977
|
| C004742 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | daidzein results in increased expression of GREB1 mRNA |
increases expression
|
mRNA |
23384675
|
| C004742 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of GREB1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C004742 | 3284 |
HSD3B2
HSD3B HSDB SDR11E2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) | daidzein inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23370353
|
| C004742 | 7866 |
IFRD2
IFNRP SKMc15 SM15 |
interferon-related developmental regulator 2 | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IFRD2 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | daidzein results in decreased expression of IGF1R mRNA |
decreases expression
|
mRNA |
16865672
|
| C004742 | 3487 |
IGFBP4
BP-4 HT29-IGFBP IBP4 IGFBP-4 |
insulin-like growth factor binding protein 4 | daidzein results in increased expression of IGFBP4 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | daidzein inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] |
decreases reaction
/ increases secretion |
protein |
17266178
|
| C004742 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | daidzein inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] |
decreases reaction
/ increases secretion |
protein |
17266178
|
| C004742 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | daidzein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21056929
|
| C004742 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | daidzein results in decreased expression of IL8 mRNA |
decreases expression
|
mRNA |
21056929
|
| C004742 | 26145 |
IRF2BP1
|
interferon regulatory factor 2 binding protein 1 | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IRF2BP1 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | daidzein results in increased expression of JUN mRNA |
increases expression
|
mRNA |
17266178
|
| C004742 | 26251 |
KCNG2
KCNF2 KV6.2 |
potassium voltage-gated channel, subfamily G, member 2 | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 354 |
KLK3
APS KLK2A1 PSA hK3 |
kallikrein-related peptidase 3 (EC:3.4.21.77) | daidzein results in decreased expression of KLK3 mRNA |
decreases expression
|
mRNA |
16865672
|
| C004742 | 27074 |
LAMP3
CD208 DC_LAMP DC-LAMP DCLAMP LAMP LAMP-3 TSC403 |
lysosomal-associated membrane protein 3 | daidzein results in decreased expression of LAMP3 mRNA |
decreases expression
|
mRNA |
20678512
|
| C004742 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | AG 1879 inhibits the reaction [daidzein results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16840783
|
| C004742 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | daidzein results in increased phosphorylation of MAPK1 protein |
increases phosphorylation
|
protein |
16840783
|
| C004742 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | AG 1879 inhibits the reaction [daidzein results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16840783
|
| C004742 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | daidzein results in increased phosphorylation of MAPK3 protein |
increases phosphorylation
|
protein |
16840783
|
| C004742 | 4199 |
ME1
HUMNDME MES |
malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) | daidzein results in increased expression of ME1 mRNA |
increases expression
|
mRNA |
16865672
|
| C004742 | 4502 |
MT2A
MT2 |
metallothionein 2A | daidzein results in increased expression of MT2A mRNA |
increases expression
|
mRNA |
10656621
|
| C004742 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | daidzein results in increased expression of MYC mRNA |
increases expression
|
mRNA |
17266178
|
| C004742 | 10499 |
NCOA2
GRIP1 KAT13C NCoA-2 SRC2 TIF2 bHLHe75 |
nuclear receptor coactivator 2 | daidzein metabolite promotes the reaction [NCOA2 protein binds to ESR1 protein] |
affects binding
/ increases reaction |
protein |
15084758
|
| C004742 | 4824 |
NKX3-1
BAPX2 NKX3 NKX3.1 NKX3A |
NK3 homeobox 1 | daidzein results in decreased expression of NKX3-1 mRNA |
decreases expression
|
mRNA |
16865672
|
| C004742 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | daidzein results in increased activity of NOS3 protein |
increases activity
|
protein |
16840783
|
| C004742 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | daidzein results in decreased expression of NQO1 mRNA |
decreases expression
|
mRNA |
18497090
|
| C004742 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | daidzein binds to and results in increased activity of NR1I2 protein |
affects binding
/ increases activity |
protein |
16054614
|
| C004742 | 8204 |
NRIP1
RIP140 |
nuclear receptor interacting protein 1 | daidzein results in increased expression of NRIP1 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 56944 |
OLFML3
HNOEL-iso OLF44 |
olfactomedin-like 3 | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of OLFML3 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | daidzein results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
12791511
|
| C004742 | 5111 |
PCNA
|
proliferating cell nuclear antigen | daidzein results in decreased expression of PCNA |
decreases expression
|
21161820
|
|
| C004742 | 64236 |
PDLIM2
MYSTIQUE SLIM |
PDZ and LIM domain 2 (mystique) | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 5174 |
PDZK1
CAP70 CLAMP NHERF-3 NHERF3 PDZD1 |
PDZ domain containing 1 | daidzein results in increased expression of PDZK1 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | daidzein results in increased expression of PGR mRNA |
increases expression
|
mRNA |
23384675
|
| C004742 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | daidzein results in increased expression of PGR protein |
increases expression
|
protein |
17142977
|
| C004742 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | ESR1 protein inhibits the reaction [daidzein results in increased expression of PGR mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C004742 | 5411 |
PNN
DRS DRSP SDK3 memA |
pinin, desmosome associated protein | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PNN mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 10957 |
PNRC1
B4-2 PNAS-145 PROL2 PRR2 |
proline-rich nuclear receptor coactivator 1 | daidzein promotes the reaction [ESRRA protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004742 | 10957 |
PNRC1
B4-2 PNAS-145 PROL2 PRR2 |
proline-rich nuclear receptor coactivator 1 | daidzein promotes the reaction [ESRRB protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004742 | 10957 |
PNRC1
B4-2 PNAS-145 PROL2 PRR2 |
proline-rich nuclear receptor coactivator 1 | daidzein promotes the reaction [ESRRG protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004742 | 5458 |
POU4F2
BRN3.2 BRN3B Brn-3b |
POU class 4 homeobox 2 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 5580 |
PRKCD
MAY1 PKCD nPKC-delta |
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) | daidzein results in decreased expression of PRKCD mRNA |
decreases expression
|
mRNA |
15757668
|
| C004742 | 11098 |
PRSS23
SIG13 SPUVE ZSIG13 |
protease, serine, 23 | daidzein results in increased expression of PRSS23 mRNA |
increases expression
|
mRNA |
23384675
|
| C004742 | 11098 |
PRSS23
SIG13 SPUVE ZSIG13 |
protease, serine, 23 | ESR1 protein inhibits the reaction [daidzein results in increased expression of PRSS23 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C004742 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | [daidzein co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA |
affects cotreatment
/ increases expression |
mRNA |
19347870
|
| C004742 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | daidzein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
16870006
|
| C004742 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | daidzein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] |
decreases reaction
/ increases expression |
protein |
16870006
|
| C004742 | 5747 |
PTK2
FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
protein tyrosine kinase 2 (EC:2.7.10.2) | daidzein results in increased phosphorylation of PTK2 protein |
increases phosphorylation
|
protein |
12421874
|
| C004742 | 5932 |
RBBP8
COM1 CTIP JWDS RIM SAE2 SCKL2 |
retinoblastoma binding protein 8 | daidzein results in increased expression of RBBP8 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 6197 |
RPS6KA3
CLS HU-3 ISPK-1 MAPKAPK1B MRX19 RSK RSK2 S6K-alpha3 p90-RSK2 pp90RSK2 |
ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) | daidzein results in increased expression of RPS6KA3 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 81537 |
SGPP1
SPPase1 |
sphingosine-1-phosphate phosphatase 1 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 6558 |
SLC12A2
BSC BSC2 NKCC1 |
solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | daidzein results in decreased expression of SLC12A2 mRNA |
decreases expression
|
mRNA |
15757668
|
| C004742 | 6513 |
SLC2A1
DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED |
solute carrier family 2 (facilitated glucose transporter), member 1 | daidzein inhibits the reaction [SLC2A1 protein affects the transport of Glucose] |
affects transport
/ decreases reaction |
protein |
14642735
|
| C004742 | 6513 |
SLC2A1
DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED |
solute carrier family 2 (facilitated glucose transporter), member 1 | daidzein results in decreased activity of SLC2A1 protein |
decreases activity
|
protein |
14642735
|
| C004742 | 8140 |
SLC7A5
4F2LC CD98 D16S469E E16 LAT1 MPE16 hLAT1 |
solute carrier family 7 (amino acid transporter light chain, L system), member 5 | daidzein results in increased expression of SLC7A5 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 6781 |
STC1
STC |
stanniocalcin 1 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 27347 |
STK39
DCHT PASK SPAK |
serine threonine kinase 39 (EC:2.7.11.1) | daidzein results in decreased expression of STK39 mRNA |
decreases expression
|
mRNA |
16865672
|
| C004742 | 6817 |
SULT1A1
HAST1/HAST2 P-PST PST ST1A1 ST1A3 STP STP1 TSPST1 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) | daidzein inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] |
decreases reaction
/ increases sulfation |
protein |
15531517
|
| C004742 | 6818 |
SULT1A3
HAST HAST3 M-PST ST1A3/ST1A4 ST1A5 STM TL-PST |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) | daidzein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine] |
decreases reaction
/ increases sulfation |
protein |
15531517
|
| C004742 | 6870 |
TACR3
HH11 NK-3R NK3R NKR TAC3RL |
tachykinin receptor 3 | [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA |
affects cotreatment
/ increases expression |
mRNA |
16963248
|
| C004742 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | daidzein results in increased expression of TFF1 mRNA |
increases expression
|
mRNA |
16965913
23384675 |
| C004742 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | ESR1 protein inhibits the reaction [daidzein results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
23384675
|
| C004742 | 7041 |
TGFB1I1
ARA55 HIC-5 HIC5 TSC-5 |
transforming growth factor beta 1 induced transcript 1 | daidzein promotes the reaction [TGFB1I1 protein results in increased activity of AR protein] |
increases activity
/ increases reaction |
protein |
17252558
|
| C004742 | 7130 |
TNFAIP6
TSG-6 TSG6 |
tumor necrosis factor, alpha-induced protein 6 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of TNFAIP6 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | daidzein results in increased expression of TP53 protein |
increases expression
|
protein |
19800779
|
| C004742 | 9537 |
TP53I11
PIG11 |
tumor protein p53 inducible protein 11 | daidzein results in decreased expression of TP53I11 mRNA |
decreases expression
|
mRNA |
15757668
|
| C004742 | 7164 |
TPD52L1
D53 hD53 |
tumor protein D52-like 1 | daidzein results in increased expression of TPD52L1 mRNA |
increases expression
|
mRNA |
15757668
|
| C004742 | 7345 |
UCHL1
NDGOA PARK5 PGP_9.5 PGP9.5 PGP95 Uch-L1 |
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16963248
|
| C004742 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | daidzein results in increased activity of UGT1A1 protein |
increases activity
|
protein |
16051636
|
| C004742 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased glucuronidation of daidzein |
increases glucuronidation
|
protein |
14557274
|
| C004742 | 54575 |
UGT1A10
UDPGT UGT-1J UGT1-10 UGT1.10 UGT1J |
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) | UGT1A10 protein results in increased glucuronidation of daidzein |
increases glucuronidation
|
protein |
14557274
|
| C004742 | 54577 |
UGT1A7
UDPGT UDPGT_1-7 UGT-1G UGT1-07 UGT1.7 UGT1G |
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) | UGT1A7 protein results in increased glucuronidation of daidzein |
increases glucuronidation
|
protein |
14557274
|
| C004742 | 54576 |
UGT1A8
UDPGT UDPGT_1-8 UGT-1H UGT1-08 UGT1.8 UGT1A8S UGT1H |
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) | UGT1A8 protein results in increased glucuronidation of daidzein |
increases glucuronidation
|
protein |
14557274
|
| C004742 | 54600 |
UGT1A9
HLUGP4 LUGP4 UDPGT UDPGT_1-9 UGT-1I UGT1-09 UGT1-9 UGT1.9 UGT1AI UGT1I |
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) | UGT1A9 protein results in increased glucuronidation of daidzein |
increases glucuronidation
|
protein |
14557274
|
| C004742 | 7367 |
UGT2B17
BMND12 UDPGT2B17 |
UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17) | daidzein results in increased expression of UGT2B17 mRNA |
increases expression
|
mRNA |
16865672
|
| C004742 | 7412 |
VCAM1
CD106 INCAM-100 |
vascular cell adhesion molecule 1 | ESR2 gene polymorphism affects the reaction [[Genistein co-treated with daidzein] affects the expression of VCAM1 protein] |
affects cotreatment
/ affects expression / affects reaction |
protein |
16332659
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (68)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #218800 | Crigler-najjar syndrome, type i |
P22310
|
| #606785 | Crigler-najjar syndrome, type ii |
P22310
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22310
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (76)
| KEGG | disease name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
12 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000230 | C004742 | Adenocarcinoma |
therapeutic
|
11473722
|
|
| D000647 | C004742 | Amnesia |
therapeutic
|
16428827
|
|
| D002318 | C004742 | Cardiovascular Diseases |
therapeutic
|
16332659
|
|
| D003924 | C004742 | Diabetes Mellitus, Type 2 |
therapeutic
|
16647724
|
|
| D004487 | C004742 | Edema |
therapeutic
|
22981962
|
|
| D016889 | C004742 | Endometrial Neoplasms |
therapeutic
|
11473722
|
|
| D007172 | C004742 | Erectile Dysfunction |
marker/mechanism
|
14972507
17905136 |
|
| D006965 | C004742 | Hyperplasia |
therapeutic
|
22981962
|
|
| D006973 | C004742 | Hypertension |
therapeutic
|
17169123
|
|
| D017254 | C004742 | Leukemic Infiltration |
therapeutic
|
22981962
|
|
| D008569 | C004742 | Memory Disorders |
therapeutic
|
21052945
|
|
| D014693 | C004742 | Ventricular Fibrillation |
therapeutic
|
15015382
|