PCIDB

KNApSAcK Metabolite C00000960

Metabolite

KNApSAcK Entry

id C00000960
Name Eriodictyol
CAS RN 552-58-9
Standard InChI InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 25

Link

ChEMBL

By standard InChI CHEMBL8996
By standard InChI Main Layer CHEMBL8996 CHEMBL307893 CHEMBL1975989

KEGG

By LinkDB C05631

CTD

By CAS RN C007619

Species

Summary

Plant class

class name count
asterids 13
rosids 8
eudicotyledons 1

Family

family name count
Asteraceae 7
Fabaceae 5
Lamiaceae 3
Rutaceae 1
Hydrophyllaceae 1
Crassulaceae 1
Convolvulaceae 1
Phyllanthaceae 1
Rhamnaceae 1
Solanaceae 1

List (22)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Anthemis altissima 99027 Asteraceae asterids Viridiplantae
Arachis hypogaea 3818 Fabaceae rosids Viridiplantae
Bauhinia guianensis 508984 Fabaceae rosids Viridiplantae
Chrysothamnus viscidiflorus 72914 Asteraceae asterids Viridiplantae
Citrus unshiu Markovich 2706 Rutaceae rosids Viridiplantae
Dipteryx odorata 53873 Fabaceae rosids Viridiplantae
Elsholtzia bodinieri 41225 Lamiaceae asterids Viridiplantae
Eriodictyon californicum 4132 Hydrophyllaceae asterids Viridiplantae
Erycibe expansa 197385 Convolvulaceae asterids Viridiplantae
Eysenhardtia subcoriacea Pennell 104319 Fabaceae rosids Viridiplantae
Filifolium sibiricum 217469 Asteraceae asterids Viridiplantae
Helichrysum bracteatum (Vent.)Andr. 59430 Asteraceae asterids Viridiplantae
Onopordum acanthium 92915 Asteraceae asterids Viridiplantae
Phlomis nissolii 997732 Lamiaceae asterids Viridiplantae
Phyllanthus emblica 296036 Phyllanthaceae rosids Viridiplantae
Rhamnus disperma 3609 Rhamnaceae rosids Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Rhodiola sachalinensis 265354 Crassulaceae eudicotyledons Viridiplantae
Saracha punctata 126905 Solanaceae asterids Viridiplantae
Spatholobus suberectus Dunn 455371 Fabaceae rosids Viridiplantae
Tessaria dodoneifolia 313941 Asteraceae asterids Viridiplantae
Thymus vulgaris 49992 Lamiaceae asterids Viridiplantae

Human Protein / Gene in interaction

32 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL307893 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
P14618 Pyruvate kinase PKM Enzyme CHEMBL307893 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL307893 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL307893 CHEMBL1614076 (1)
1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL8996 CHEMBL1225717 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL307893 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL307893 CHEMBL1614458 (1)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL8996 CHEMBL2342404 (1)
1 / 1
P39748 Flap endonuclease 1 Enzyme CHEMBL307893 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL307893 CHEMBL2114780 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL307893 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL307893 CHEMBL1738315 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL307893 CHEMBL1738614 (1)
3 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL307893 CHEMBL1963893 (2)
0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL8996 CHEMBL1225718 (1)
4 / 4
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL307893 CHEMBL1613808 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL307893 CHEMBL1738514 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL8996 CHEMBL1225716 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL307893 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL307893 CHEMBL1614038 (1)
2 / 2
P22303 Acetylcholinesterase Hydrolase CHEMBL8996 CHEMBL2014392 (1) CHEMBL2014393 (1)
1 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL307893 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL307893 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL307893 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL307893 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL307893 CHEMBL1614466 (1) CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL307893 CHEMBL1614421 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL307893 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL307893 CHEMBL1613914 (2)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL307893 CHEMBL1613829 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL307893 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL307893 CHEMBL2114796 (1)
2 / 1

CTD interaction (5)

compound gene gene name gene description interaction interaction type form reference
pmid
C007619 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 eriodictyol results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C007619 2950 GSTP1
DFN7
FAEES3
GST3
GSTP
PI
glutathione S-transferase pi 1 (EC:2.5.1.18) eriodictyol results in decreased activity of GSTP1 protein decreases activity
protein 15041478
C007619 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) eriodictyol results in increased expression of HMOX1 protein increases expression
protein 16799064
C007619 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 eriodictyol results in increased expression of NFE2L2 protein increases expression
protein 16799064
C007619 29110 TBK1
NAK
T2K
TANK-binding kinase 1 (EC:2.7.11.1) eriodictyol results in decreased activity of TBK1 protein decreases activity
protein 19426678

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc Q14191
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#232300 Glycogen storage disease ii P10253
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (55)

KEGG disease name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00213 Hypophosphatasia P05186 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)