KCF-S cluster No. 111 (42 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (42)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	41
rosids	15
eudicotyledons	7
Liliopsida	2
Embryophyta	1
Spermatophyta	1
Viridiplantae	1

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Cumulative family count (Top 20)

class name	count
Coriolaceae	36
Rubiaceae	30
Saccharomycetaceae	29
Ganodermataceae	20
Boletaceae	18
Phaffomycetaceae	11
Aspergillaceae	11
Brassicaceae	8
Suillaceae	8
Russulaceae	7
Polyporaceae	7
Nectriaceae	6
Ustilaginaceae	6
Phycomycetaceae	6
Schizophyllaceae	5
Tricholomataceae	5
Pichiaceae	5
Strophariaceae	5
Agaricaceae	4
Hymenochaetaceae	4

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Cholestane	1
Stigmastane	2

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Cholestane	C08825	C00003659
Stigmastane	C08839	C00003671
Stigmastane	C08840	C00003673

Metabolite list (42)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003652	Ergosterol / Ergosta-5,7,22-trien-3beta-ol	CHEMBL222608 CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225	D004875	12 / 14 / 11
C00003659	Lophenol		C008421
C00003671	Schottenol	CHEMBL238597
C00003673	Spinasterol / (-)-Spinasterol / alpha-Spinasterin / alpha-Spinasterol	CHEMBL487783	C031312
C00007261	5-Dehydroepisterol / Ergosta-5,7,24(28)-trien-3beta-ol / 24-Methylcholesta-5,7,24(28)-trienol
C00007272	Episterol		C060242
C00007320	24-Methylenelophenol
C00007321	24-Ethylidenelophenol	CHEMBL1394708		5 / 5 / 4
C00007322	delta7-Avenasterol
C00007523	4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C00007524	4alpha-Methylfecosterol		C023800
C00007527	5-Dehydroavenasterol
C00023744	Lathosterol / Cholest-7-en-3beta-ol	CHEMBL1515367	C001521	7 / 7 / 10	0 / 3
C00023746	Cholest-8(9)-en-3beta-ol
C00023747	7-Dehydrocholesterol / Provitamin D3,Cholesta-5,7-dien-3beta-ol	CHEMBL1480760 CHEMBL1797131	C016705	5 / 6 / 13	1 / 1
C00023748	Cholesta-7,24-dien-3beta-ol
C00023749	Zymosterol / Cholesta-7,24-dien-3beta-ol		C015582		1 / 0
C00023750	Ergost-8-en-3beta-ol / (24S)24-Methylcholest-8-en-3beta-ol	CHEMBL287550	C061769
C00023751	Fecosterol / Ergosta-8,24(28)-dien-3beta-ol / 24-Methylcholesta-8,24(28)-dien-3beta-ol		C039241
C00023752	Fungisterol / Ergost-7-en-3beta-ol / (24S)24-Methylcholest-7-en-3beta-ol
C00023753	Ergosta-5,7-dien-3beta-ol / (24S)24-Methylcholesta-5,7-dien-3beta-ol		C012287
C00023754	5,6-Dehydroergosterol / Ergosta-7,22-dien-3beta-ol / 24-Methylcholesta-7,22-dien-3beta-ol	CHEMBL463973 CHEMBL560819
C00023757	22,23-Dihydroergosterol / Ergosta-5,7-dien-3beta-ol		C012287
C00023759	Ignosterol / Ergosta-8,(9)14-dien-3beta-ol / (24S)24-Methylcholesta-8(9),14-dien-3beta-ol		C015291
C00023760	Ergosta-8,14,24(28)-trien-3beta-ol
C00023763	Pyrocalciferol	CHEMBL222608 CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225		12 / 14 / 11
C00023764	Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C00023765	Ergosta-7,22-dien-3-one / (24S)24-Methylcholesta-7,22-dien-3-one	CHEMBL516711 CHEMBL1514671	C059439	1 / 0 / 1
C00023768	4alpha-Methylzymosterol
C00023771	7-Dehydrofucosterol / (24R)24-Ethylcholesta-5,7,24(28)-trien-3beta-ol
C00023772	Stigmasta-5,7-dien-3beta-ol / (24S)24-Ethylcholesta-5,7-dien-3beta-ol		C038421
C00023776	14-Demethyllanosterol / 4,4-Dimethylzymosterol		C013499
C00033758	delta7 Stigmastenol / (3beta)-Stigmast-7-en-3-ol	CHEMBL238597	C031313
C00033775	Dihydrozymosterol		C056855		0 / 1
C00035362	Peniocerol
C00036119	Gramisterol
C00038091	(24R)-24-Hydroxy-24-vinyllathosterol
C00038092	(24S)-24-Hydroxy-24-vinyllathosterol
C00042082	24xi-Methyllathosterol
C00046997	7alpha-Hydroxytheonellasterol / (+)-7alpha-Hydroxytheonellasterol
C00047105	Theonellasterol	CHEMBL1085679
C00050242	Swinhosterol C / (-)-Swinhosterol C

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11473	Vitamin D3 receptor	NR1I1	C00003652 C00007321 C00023747 C00023763	2 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00003652 C00007321 C00023744 C00023763	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00003652 C00023744 C00023763	4 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003652 C00023763 C00023765	0 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003652 C00023744 C00023763	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00003652 C00023744 C00023763	0 / 0
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00003652 C00023763	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003652 C00023763	1 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003652 C00023763	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003652 C00023763	0 / 1
O00255	Menin	Unclassified protein	C00023744 C00023747	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00023744 C00023747	1 / 2
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00003652 C00023763	5 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003652 C00023763	1 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00007321	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00007321	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00007321	3 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00023744	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00023747	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00023747	1 / 4

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1593	CYP27A1, CP27, CTX, CYP27	cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15)	C00023749
1717	DHCR7, SLOS	7-dehydrocholesterol reductase (EC:1.3.1.21)	C00023747

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions