KCF-S cluster No. 1910 (5 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	10
Liliopsida	6
asterids	2
Magnoliophyta	1

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Cumulative family count

class name	count
Fabaceae	8
Thorectidae	3
Solanaceae	2
Poaceae	2
Musaceae	2
Urticaceae	1
Araceae	1
Clionaidae	1
Elaeagnaceae	1
Bromeliaceae	1
Lauraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Indole alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Indole alkaloids	C00780	C00001429

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000104	5-Hydroxyindole-3-acetic acid	CHEMBL395915	D006897	22 / 32 / 22	0 / 8
C00001371	5-Hydroxy-L-tryptophan	CHEMBL350221 CHEMBL162789		27 / 34 / 26
C00001429	Serotonin / Enteramin / Enteramine / DS substance / Thrombotonin / Thrombocytin / 5-Hydroxytryptamine	CHEMBL39 CHEMBL1628597	D012701	78 / 35 / 22	32 / 40
C00042603	Hyrtioerectine C	CHEMBL1162274
C00045185	5-Hydroxy-3-(2-hydroxyethyl)-indole		D006917		2 / 0

Human Protein / Gene in interactions

108 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000104 C00001371 C00001429	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000104 C00001371 C00001429	3 / 2
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000104 C00001371 C00001429	2 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000104 C00001371 C00001429	0 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000104 C00001371	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000104 C00001429	1 / 1
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00000104 C00001371	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000104 C00001371	1 / 0
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000104 C00001371	5 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000104 C00001429	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000104 C00001371	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000104 C00001371	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000104 C00001429	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000104 C00001429	1 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000104 C00001371	11 / 10
P22748	Carbonic anhydrase 4	Lyase	C00001429	1 / 1
P43166	Carbonic anhydrase 7	Lyase	C00001429	0 / 0
P23415	Glycine receptor subunit alpha-1	GLR alpha	C00001429	1 / 1
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00001429	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00001371	3 / 1
P00918	Carbonic anhydrase 2	Lyase	C00001429	1 / 2
P28222	5-hydroxytryptamine receptor 1B	Serotonin receptor	C00001429	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00001429	0 / 0
P47898	5-hydroxytryptamine receptor 5A	Serotonin receptor	C00001429	0 / 0
P02768	Serum albumin	Secreted protein	C00000104	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00001429	0 / 0
P16662	UDP-glucuronosyltransferase 2B7	Enzyme	C00001429	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001371	1 / 2
P11473	Vitamin D3 receptor	NR1I1	C00000104	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00001429	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001429	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00001429	0 / 0
P05164	Myeloperoxidase	Enzyme	C00001429	1 / 2
P28566	5-hydroxytryptamine receptor 1E	Serotonin receptor	C00001429	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00001429	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00001429	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00001429	1 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001429	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000104	2 / 0
O75496	Geminin	Unclassified protein	C00000104	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00001429	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001429	1 / 0
P46098	5-hydroxytryptamine receptor 3A	NS	C00001429	0 / 0
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00001429	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00001429	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001371	1 / 2
Q13639	5-hydroxytryptamine receptor 4	Serotonin receptor	C00001429	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00001371	0 / 1
P14679	Tyrosinase	Oxidoreductase	C00001429	4 / 2
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001429	2 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00001429	0 / 0
P36544	Neuronal acetylcholine receptor subunit alpha-7	CHRN alpha	C00001429	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00000104	1 / 1
P48039	Melatonin receptor type 1A	Melatonin receptor	C00001429	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001429	0 / 3
Q16790	Carbonic anhydrase 9	Lyase	C00001429	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001371	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000104	2 / 2
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001429	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00001371	0 / 0
P06133	UDP-glucuronosyltransferase 2B4	Enzyme	C00001429	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001429	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001429	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001429	0 / 0
Q7Z2W7	Transient receptor potential cation channel subfamily M member 8	Unclassified protein	C00001429	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001371	0 / 0
O15244	Solute carrier family 22 member 2	Drug uniporter	C00001429	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001371	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001371	0 / 0
O75795	UDP-glucuronosyltransferase 2B17	Enzyme	C00001429	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001371	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00001429	5 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00001371	4 / 3
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00001429	3 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00001429	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001371	0 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00001429	1 / 0
P28221	5-hydroxytryptamine receptor 1D	Serotonin receptor	C00001429	0 / 0
P30939	5-hydroxytryptamine receptor 1F	Serotonin receptor	C00001429	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00001429	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00001371	0 / 0
P49286	Melatonin receptor type 1B	Melatonin receptor	C00001429	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001371	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001429	0 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00001371	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00000104	1 / 0
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00001429	0 / 0
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00001429	1 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00001429	1 / 1
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00001429	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00001429	1 / 1
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00001429	0 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00001429	0 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00001429	0 / 0
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00001429	0 / 0
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00001429	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00001429	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00001429	0 / 0
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00001429	4 / 2
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00001429	0 / 0
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00001429	0 / 0
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00001429	1 / 0
O75751	Solute carrier family 22 member 3	Unclassified protein	C00001429	0 / 0
Q8WXA8	5-hydroxytryptamine receptor 3C	NS	C00001429	0 / 0
Q70Z44	5-hydroxytryptamine receptor 3D	NS	C00001429	0 / 0
O95264	5-hydroxytryptamine receptor 3B	NS	C00001429	0 / 0
A5X5Y0	5-hydroxytryptamine receptor 3E	NS	C00001429	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001371	0 / 0

32 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00001429 C00045185
6818	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1)	C00001429 C00045185
4128	MAOA, MAO-A	monoamine oxidase A (EC:1.4.3.4)	C00001429
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001429
2597	GAPDH, G3PD, GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	C00001429
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00001429
3352	HTR1D, 5-HT1D, HT1DA, HTR1DA, HTRL, RDC4	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	C00001429
3356	HTR2A, 5-HT2A, HTR2	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	C00001429
3359	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	C00001429
9177	HTR3B, 5-HT3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	C00001429
3363	HTR7, 5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	C00001429
3593	IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	C00001429
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001429
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001429
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001429
3690	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	C00001429
847	CAT	catalase (EC:1.11.1.6)	C00001429
4353	MPO	myeloperoxidase (EC:1.11.2.2)	C00001429
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001429
6570	SLC18A1, CGAT, VAT1, VMAT1	solute carrier family 18 (vesicular monoamine transporter), member 1	C00001429
6571	SLC18A2, SVAT, SVMT, VAT2, VMAT2	solute carrier family 18 (vesicular monoamine transporter), member 2	C00001429
85413	SLC22A16, CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1	solute carrier family 22 (organic cation/carnitine transporter), member 16	C00001429
6530	SLC6A2, NAT1, NET, NET1, SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 2	C00001429
6531	SLC6A3, DAT, DAT1, PKDYS	solute carrier family 6 (neurotransmitter transporter), member 3	C00001429
6532	SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT	solute carrier family 6 (neurotransmitter transporter), member 4	C00001429
6814	STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C	syntaxin binding protein 3	C00001429
134864	TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1	trace amine associated receptor 1	C00001429
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001429
7166	TPH1, TPRH, TRPH, TPH	tryptophan hydroxylase 1 (EC:1.14.16.4)	C00001429
8989	TRPA1, ANKTM1, FEPS	transient receptor potential cation channel, subfamily A, member 1	C00001429
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00001429
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00001429

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions