KCF-S cluster No. 285 (24 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (24)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	42
rosids	42
eudicotyledons	9
Spermatophyta	7
Magnoliophyta	2

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Cumulative family count

class name	count
Acanthaceae	35
Rutaceae	22
Phyllanthaceae	13
Berberidaceae	9
Cupressaceae	7
Polygalaceae	2
Araliaceae	2
Apiaceae	2
Asteraceae	2
Salicaceae	1
Hernandiaceae	1
Lamiaceae	1
Fabaceae	1
Lauraceae	1
Linaceae	1
Clusiaceae	1
Burseraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10633	C00000700
Lignans	C10636	C00000701
Lignans	C10877	C00000727
Lignans	C10559	C00002600

Metabolite list (24)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000611	Justicidin E	CHEMBL304236		1 / 0 / 0
C00000700	Justicidin A	CHEMBL508532	C049719
C00000701	Justicidin B
C00000711	Retrojusticidin B	CHEMBL292540		1 / 0 / 0
C00000720	Neojusticin A	CHEMBL455369
C00000721	Taiwanin E	CHEMBL468453
C00000727	Prostalidin A
C00000728	Prostalidin B
C00000729	Prostalidin C
C00002600	Diphyllin	CHEMBL221190	C010130	24 / 43 / 38
C00007210	Dehydropodophyllotoxin / Tetradehydropodophyllotoxin	CHEMBL487214
C00007211	Helioxanthin	CHEMBL436474
C00030455	Haplomyrtin
C00031016	Phyllanthusmin A
C00031681	Cleistanone / (+)-Cleistanone
C00036091	Chaihunaphthone
C00036092	Chinensinaphthol	CHEMBL495476
C00037881	Taiwanin C	CHEMBL65755		1 / 0 / 0
C00049571	Cilinaphthalide A	CHEMBL491523
C00049572	Cilinaphthalide B	CHEMBL521623
C00049574	Chinensinaphthol methyl ether	CHEMBL510411
C00049575	Neojusticin B	CHEMBL455623
C00049576	Taiwanin E methyl ether	CHEMBL495475
C00049959	5-Methoxyjusticidin A

Human Protein / Gene in interactions

25 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000611 C00000711 C00037881	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002600	0 / 0
Q9Y5X4	Photoreceptor-specific nuclear receptor	NR2E3	C00002600	2 / 2
P02545	Prelamin-A/C	Unclassified protein	C00002600	11 / 10
P11388	DNA topoisomerase 2-alpha	Isomerase	C00002600	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002600	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002600	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002600	2 / 2
P42858	Huntingtin	Unclassified protein	C00002600	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002600	2 / 0
O75496	Geminin	Unclassified protein	C00002600	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002600	4 / 2
Q99700	Ataxin-2	Unclassified protein	C00002600	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002600	7 / 3
P51843	Nuclear receptor subfamily 0 group B member 1	Nuclear hormone receptor subfamily 0 group B member 1	C00002600	2 / 2
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002600	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002600	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00002600	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002600	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002600	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002600	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002600	1 / 0
O00255	Menin	Unclassified protein	C00002600	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002600	1 / 2
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00002600	0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions