KCF-S cluster No. 293 (23 metabolites)

Corresponding Phytochemical cluster No. 32

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (23)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Liliopsida	27

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Cumulative family count

class name	count
Zingiberaceae	27

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Zingiber derived compounds	4

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Zingiber derived compounds	C10462	C00002748
Zingiber derived compounds	C10482	C00002764
Zingiber derived compounds	C10494	C00002774
Zingiber derived compounds	C10494	C00031419
Zingiber derived compounds	C17495	C00031475

Metabolite list (23)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002746	[6]-Gingerdione		C050872
C00002748	[6]-Gingerol / (S)-6-Gingerol / (S)-(+)-[6]Gingerol	CHEMBL402978 CHEMBL1950582		4 / 4 / 0
C00002764	[6]-Paradol	CHEMBL2071440	C421614
C00002774	[6]-Shogaol	CHEMBL25948	C040115	8 / 3 / 4	10 / 1
C00031418	trans-10-Shogaol	CHEMBL24226		2 / 2 / 0
C00031419	trans-6-Shogaol	CHEMBL25948		8 / 3 / 4
C00031474	(S)-10-Gingerol / (+)-(S)-[10]-Gingerol	CHEMBL549472		2 / 2 / 0
C00031475	[8]-Gingerol / (S)-8-Gingerol / (+)-[8]-Gingerol	CHEMBL1095671		2 / 2 / 0
C00034994	10-Shogaol / [10]-Shogaol	CHEMBL24226		2 / 2 / 0
C00035032	[7]-Paradol	CHEMBL431200
C00035035	[8]-Shogaol	CHEMBL25893		2 / 2 / 0
C00035036	[9]-Paradol
C00035442	[10]-Gingerdiol
C00035443	[12]-Shogaol	CHEMBL24703
C00035444	[4]-Gingerol
C00035445	[4]-Isogingerol
C00035446	[4]-Shogaol	CHEMBL277440
C00035447	[6]-Gingerdiol	CHEMBL2071441 CHEMBL2071442
C00035448	[7]-Gingerol
C00035450	[8]-Paradol
C00035687	Methyl [6]-paradol
C00035688	Methyl [6]-Shogaol
C00035689	Methyl [8]-Shogaol

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00002748 C00002774 C00031418 C00031419 C00031474 C00031475 C00034994 C00035035	1 / 0
P08183	Multidrug resistance protein 1	drug	C00002748 C00002774 C00031418 C00031419 C00031474 C00031475 C00034994 C00035035	1 / 0
Q8NER1	Transient receptor potential cation channel subfamily V member 1	TRPV (Vanilloid)	C00002748 C00002774 C00031419	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002774 C00031419	1 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002774 C00031419	0 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002774 C00031419	0 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002774 C00031419	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002774 C00031419	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002748	2 / 0

10 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
581	BAX, BCL2L4	BCL2-associated X protein	C00002774
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002774
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002774
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002774
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00002774
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00002774
1676	DFFA, DFF-45, DFF1, ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	C00002774
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00002774
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00002774
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002774

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions