KCF-S cluster No. 323 (21 metabolites)

Corresponding Phytochemical cluster No. 41

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (21)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	26
asterids	11
Magnoliophyta	3
rosids	2

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Cumulative family count

class name	count
Pinaceae	13
Podocarpaceae	10
Lamiaceae	9
Cupressaceae	3
Schisandraceae	3
Apiaceae	2
Nocardiaceae	1
Fabaceae	1
Celastraceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Others	1
Podocarpanes	2

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Others	C09163	C00003470
Podocarpanes	C09171	C00003474
Podocarpanes	C12078	C00042455

Metabolite list (21)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003470	Pisiferic acid		C060710
C00003474	Podocarpic acid	CHEMBL421115 CHEMBL2220581	C002470	8 / 4 / 1
C00029387	12-O-methylcarnosic acid / 12-O-Methyl carnosic acid / (+)-12-O-Methyl carnosic acid / Carnosic acid 12-methyl ether	CHEMBL1096627
C00029401	15-Hydroxydehydroabietic acid	CHEMBL598566 CHEMBL1348397		6 / 8 / 4
C00029523	4beta-Carboxy-19-nortotarol	CHEMBL517672
C00030622	Lambertic acid / (+)-Lambertic acid	CHEMBL519807 CHEMBL523920		1 / 1 / 1
C00034400	7-Oxo-15-hydroxydehydroabietic acid	CHEMBL597920
C00035978	7-Oxodehydroabietic acid / 7-Ketodehydroabietic acid	CHEMBL597919	C095375	1 / 1 / 1
C00036186	O-Methylpisiferic acid	CHEMBL479111
C00036880	Carnosic acid	CHEMBL484853 CHEMBL1397655	C018381	17 / 23 / 55	6 / 4
C00040763	12,15-Dihydroxyabieta-8,11,13-trien-18-oic acid
C00040773	16-nor-15-Oxoabieta-8,11,13-trien-18-oic acid
C00040858	Abieta-8,11,13,15-tetraen-18-oic acid
C00042455	Dehydroabietic acid	CHEMBL12850	C013913
C00046986	12-Hydroxydehydroabietic acid / (+)-12-Hydroxydehydroabietic acid	CHEMBL519807 CHEMBL523920		1 / 1 / 1
C00047642	15-Hydroxy-6-en-dehydroabietic acid / (-)-15-Hydroxy-6-en-dehydroabietic acid
C00048932	16-Hydroxycarnosic acid
C00049963	7beta-Hydroxyabieta-8,11,13-trien-18-oic acid / (+)-7beta-Hydroxyabieta-8,11,13-trien-18-oic acid	CHEMBL604665 CHEMBL604787
C00049984	Angustanoic acid F	CHEMBL598566 CHEMBL1348397		6 / 8 / 4
C00049989	Angustanoic acid E
C00049990	Angustanoic acid G / (+)-Angustanoic acid G

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00003474 C00030622 C00035978 C00046986	1 / 1
P06746	DNA polymerase beta	Enzyme	C00029401 C00049984	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00029401 C00049984	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00029401 C00049984	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00029401 C00049984	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00029401 C00049984	7 / 3
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00029401 C00049984	0 / 0
P55055	Oxysterols receptor LXR-beta	NR1H3	C00003474	0 / 0
P16233	Pancreatic triacylglycerol lipase	Hydrolase	C00036880	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00036880	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00036880	2 / 3
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00036880	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00036880	2 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00003474	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00036880	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00036880	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00036880	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00036880	2 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00036880	0 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003474	2 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00036880	7 / 37
P10636	Microtubule-associated protein tau	Unclassified protein	C00036880	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00036880	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00036880	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00036880	1 / 1
O00255	Menin	Unclassified protein	C00036880	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00036880	1 / 2
Q15118	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial	Pdhk	C00003474	0 / 0
Q16654	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial	Pdhk	C00003474	0 / 0
Q15119	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	Pdhk	C00003474	0 / 0
Q15120	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial	Pdhk	C00003474	1 / 0

6 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
100136148			C00036880
929	CD14	CD14 molecule	C00036880
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00036880
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00036880
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00036880
7421	VDR, NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	C00036880

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions