KCF-S cluster No. 430 (17 metabolites)
Corresponding Phytochemical cluster No. 4
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 38 |
Cumulative family count
| class name | count |
|---|---|
| Apocynaceae | 32 |
| Apiaceae | 6 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Indole alkaloids | 1 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Indole alkaloids | C09042 | C00024452 |
| Indole alkaloids | C09042 | C00024465 |
Metabolite list (17)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00024452
|
(-)-Aspidospermine
|
CHEMBL519457
|
C091896
|
|
||
|
C00024464
|
(+)-Aspidospermidine
|
|
||||
|
C00024465
|
(+)-Aspidospermine
|
CHEMBL519457
|
C091896
|
|
||
|
C00024483
|
12-O-Methylanomaline
|
|
||||
|
C00024513
|
Anomalin
/ Anomaline |
|
||||
|
C00024515
|
Aspidocarpine
|
CHEMBL1173074
CHEMBL1317059 CHEMBL1338579 |
5 / 5 / 9 |
|
||
|
C00024519
|
Aspidosine
/ N-Deacetyl-O-demethylaspidospermine |
|
||||
|
C00024530
|
Demethoxyanomaline
|
|
||||
|
C00024569
|
Limapodine
/ (+)-Limapodine / N-Acetyl-N-depropionyllimaspermine |
|
||||
|
C00024570
|
Limaspermidine
/ Aspidospermidin-21-ol |
|
||||
|
C00024571
|
Limaspermine
|
|
||||
|
C00024583
|
N-Acetylaspidospermidine
|
|
||||
|
C00024602
|
Strictanine
|
|
||||
|
C00024609
|
Vallesine
/ N-Deacetyl-N-formylaspidospermine |
|
||||
|
C00025834
|
Cylindrocarpidine
|
|
||||
|
C00025888
|
Homocylindrocarpidine
|
|
||||
|
C00025983
|
O-Demethylpalosine
|
|
Human Protein / Gene in interactions
5 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00024515 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00024515 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00024515 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00024515 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00024515 | 1 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
KEGG DISEASE (9)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|