KCF-S cluster No. 580 (14 metabolites)

Corresponding Phytochemical cluster No. 4


Plant Species


Cumulative plant class count

class name count
Liliopsida 55

Cumulative family count

class name count
Amaryllidaceae 55

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001570 External link 512 Jilkon
/ Lycoremin
/ Lycoremine
/ Galanthamine
/ (-)-Galanthamine
CHEMBL659
CHEMBL492193
CHEMBL1565544
CHEMBL1623394
CHEMBL1624158
D005702
104 / 57 / 53 3 / 25
C00001578 External link 512 Narwedine
CHEMBL2146604
C069154
C00024389 External link 512 Epigalanthamine
CHEMBL659
CHEMBL492193
CHEMBL1565544
CHEMBL1623394
CHEMBL1624158
104 / 57 / 53
C00024405 External link 512 Lycoramine
/ Dihydrogalanthamine
/ 1,2-Dihydrogalanthamine
CHEMBL2146605
C00024411 External link 512 N-Allylnorgalanthamine
CHEMBL399515
C00024414 External link 512 Norgalantamine
/ N-Norgalanthamine
/ N-Demethylgalanthamine
CHEMBL1385
1 / 1 / 0
C00024417 External link 512 O-Demethyllycoramine
C00024436 External link 512 Sanguinine
CHEMBL1524
1 / 1 / 0
C00027607 External link 512 Norgalantamine
/ N-Norgalanthamine
/ N-Demethylgalanthamine
/ (-)-N-Demethylgalanthamine
CHEMBL1385
1 / 1 / 0
C00027608 External link 512 (-)-N-Demethyllycoramine
C00027657 External link 512 11alpha-Hydroxygalanthamine
C00028682 External link 512 N-Formylgalanthamine
C00028725 External link 512 Norlycoramine
C00028732 External link 512 Norsanguinine

Human Protein / Gene in interactions

104 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22303 Acetylcholinesterase Hydrolase C00001570 C00024389 C00024414 C00024436 C00027607 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001570 C00024389 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001570 C00024389 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001570 C00024389 2 / 2
P08246 Neutrophil elastase S1A C00001570 C00024389 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00001570 C00024389 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001570 C00024389 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001570 C00024389 0 / 0
P29466 Caspase-1 C14 C00001570 C00024389 0 / 0
P17252 Protein kinase C alpha type Alpha C00001570 C00024389 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001570 C00024389 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001570 C00024389 2 / 2
P02545 Prelamin-A/C Unclassified protein C00001570 C00024389 11 / 10
P00918 Carbonic anhydrase 2 Lyase C00001570 C00024389 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001570 C00024389 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001570 C00024389 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001570 C00024389 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001570 C00024389 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001570 C00024389 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001570 C00024389 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001570 C00024389 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001570 C00024389 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001570 C00024389 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001570 C00024389 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001570 C00024389 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001570 C00024389 0 / 1
Q13224 Glutamate receptor ionotropic, NMDA 2B NS C00001570 C00024389 1 / 0
Q05586 Glutamate receptor ionotropic, NMDA 1 NS C00001570 C00024389 1 / 0
Q12879 Glutamate receptor ionotropic, NMDA 2A NS C00001570 C00024389 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001570 C00024389 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00001570 C00024389 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00001570 C00024389 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001570 C00024389 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001570 C00024389 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001570 C00024389 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001570 C00024389 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001570 C00024389 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001570 C00024389 0 / 0
P05067 Amyloid beta A4 protein Membrane receptor C00001570 C00024389 2 / 2
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001570 C00024389 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001570 C00024389 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001570 C00024389 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001570 C00024389 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001570 C00024389 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00001570 C00024389 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001570 C00024389 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001570 C00024389 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001570 C00024389 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001570 C00024389 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001570 C00024389 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001570 C00024389 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001570 C00024389 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001570 C00024389 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001570 C00024389 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001570 C00024389 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001570 C00024389 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001570 C00024389 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001570 C00024389 0 / 0
P08311 Cathepsin G S1A C00001570 C00024389 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001570 C00024389 1 / 0
P03956 Interstitial collagenase M10A C00001570 C00024389 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001570 C00024389 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001570 C00024389 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001570 C00024389 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001570 C00024389 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001570 C00024389 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001570 C00024389 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001570 C00024389 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001570 C00024389 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001570 C00024389 0 / 0
P06276 Cholinesterase Hydrolase C00001570 C00024389 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001570 C00024389 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001570 C00024389 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001570 C00024389 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001570 C00024389 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001570 C00024389 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001570 C00024389 2 / 1
P56817 Beta-secretase 1 A1A C00001570 C00024389 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001570 C00024389 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001570 C00024389 0 / 0
P03372 Estrogen receptor NR3A1 C00001570 C00024389 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001570 C00024389 1 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001570 C00024389 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001570 C00024389 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001570 C00024389 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001570 C00024389 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001570 C00024389 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001570 C00024389 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001570 C00024389 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001570 C00024389 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001570 C00024389 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001570 C00024389 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001570 C00024389 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001570 C00024389 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001570 C00024389 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001570 C00024389 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001570 C00024389 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001570 C00024389 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001570 C00024389 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001570 C00024389 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001570 C00024389 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00001570 C00024389 1 / 0
O00255 Menin Unclassified protein C00001570 C00024389 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001570 C00024389 1 / 2

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00001570
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00001570
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00001570

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (57)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#104300 Alzheimer disease; ad P05067
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605714 Cerebral amyloid angiopathy, app-related P05067
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613970 Mental retardation, autosomal dominant 6; mrd6 Q13224
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#614254 Mental retardation, autosomal dominant 8; mrd8 Q05586
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (53)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00056 Alzheimer's disease (AD) P05067 (related)
H01185 Cerebral amyloid angiopathy (CAA) P05067 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

25 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000544 Alzheimer Disease C00001570
D000647 Amnesia C00001570
D054537 Atrioventricular Block C00001570
D001321 Autistic Disorder C00001570
D001919 Bradycardia C00001570
D003072 Cognition Disorders C00001570
D003693 Delirium C00001570
D015140 Dementia, Vascular C00001570
D003967 Diarrhea C00001570
D062787 Drug Overdose C00001570
D004421 Dystonia C00001570
D006261 Headache C00001570
D006948 Hyperkinesis C00001570
D007022 Hypotension C00001570
D007859 Learning Disorders C00001570
D008133 Long QT Syndrome C00001570
D020258 Neurotoxicity Syndromes C00001570
D010243 Paralysis C00001570
D010259 Paranoid Disorders C00001570
D011041 Poisoning C00001570
D049188 Prenatal Injuries C00001570
D012640 Seizures C00001570
D013575 Syncope C00001570
D014202 Tremor C00001570
D014839 Vomiting C00001570