KCF-S cluster No. 666 (13 metabolites)
Corresponding Phytochemical cluster No. 1
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 113 |
| rosids | 23 |
Cumulative family count
| class name | count |
|---|---|
| Solanaceae | 113 |
| Erythroxylaceae | 17 |
| Rhizophoraceae | 3 |
| Brassicaceae | 2 |
| Elaeocarpaceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Tropane alkaloids | 9 |
metabolites link (9)
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002274
|
Anisodamine
|
CHEMBL2165224
|
|
|||
|
C00002275
|
Apoatropine
|
|
||||
|
C00002277
|
Atropine
|
CHEMBL9751
CHEMBL517712 CHEMBL1257084 CHEMBL1331216 CHEMBL1379091 CHEMBL2112074 |
D001285
|
110 / 58 / 58 | 44 / 99 |
|
|
C00002286
|
Cochlearine
|
CHEMBL1904999
|
2 / 0 / 0 |
|
||
|
C00002292
|
Hyoscine
/ Scopolamine / Scopine tropate / Scopine (-)-tropate |
CHEMBL13030
CHEMBL253569 CHEMBL508322 CHEMBL569713 CHEMBL608810 CHEMBL1187846 CHEMBL1201069 CHEMBL1324521 CHEMBL1418417 CHEMBL1434831 CHEMBL1531863 CHEMBL1620047 CHEMBL1906925 |
D012601
|
23 / 26 / 19 | 8 / 72 |
|
|
C00002293
|
Hyoscyamine
/ (-)-Hyoscyamine |
CHEMBL9751
CHEMBL517712 CHEMBL1257084 CHEMBL1331216 CHEMBL1379091 CHEMBL2112074 |
D064692
|
110 / 58 / 58 |
|
|
|
C00002295
|
Littorine
|
C063158
|
|
|||
|
C00002297
|
Norhyoscyamine
|
CHEMBL66410
|
|
|||
|
C00002305
|
Tropacocain
/ Benzoylpseudotropine / Pseudotropine benzoate / 3beta-Benzoyloxytropane |
CHEMBL419588
CHEMBL509945 CHEMBL1947051 CHEMBL1947052 CHEMBL2113329 |
C005862
|
5 / 2 / 1 | 1 / 0 |
|
|
C00025552
|
Benzoyltropine
/ O-Benzoyltropine / 3alpha-Benzoyloxytropane |
CHEMBL419588
CHEMBL509945 CHEMBL1947051 CHEMBL1947052 CHEMBL2113329 |
5 / 2 / 1 |
|
||
|
C00025555
|
3alpha-Phenylacetoxytropane
|
CHEMBL1190384
|
|
|||
|
C00025560
|
7beta-Hydroxyhyoscyamine
/ (+)-7b-Hydroxyhyoscyamine |
CHEMBL2165224
|
|
|||
|
C00037121
|
Erythrozeylanine B
|
|
Human Protein / Gene in interactions
119 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002277 C00002292 C00002293 | 1 / 0 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00002277 C00002292 C00002293 | 3 / 2 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00002277 C00002292 C00002293 | 2 / 2 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00002277 C00002292 C00002293 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002277 C00002292 C00002293 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002277 C00002286 C00002293 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002277 C00002292 C00002293 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002277 C00002292 C00002293 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00002277 C00002292 C00002293 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002277 C00002292 C00002293 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002277 C00002292 C00002293 | 0 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002277 C00002292 C00002293 | 1 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002277 C00002292 C00002293 | 0 / 0 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00002277 C00002292 C00002293 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002277 C00002292 C00002293 | 11 / 10 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002277 C00002292 C00002293 | 2 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002277 C00002292 C00002293 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002277 C00002292 C00002293 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002277 C00002292 C00002293 | 0 / 1 |
| P02768 | Serum albumin | Secreted protein | C00002277 C00002292 C00002293 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002277 C00002292 C00002293 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002277 C00002293 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002277 C00002293 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002277 C00002293 | 0 / 0 |
| O95264 | 5-hydroxytryptamine receptor 3B | NS | C00002305 C00025552 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002277 C00002293 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002277 C00002293 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002277 C00002293 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002277 C00002293 | 1 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00002305 C00025552 | 1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00002305 C00025552 | 1 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00002277 C00002293 | 1 / 2 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002277 C00002293 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002277 C00002293 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002277 C00002293 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002277 C00002293 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002277 C00002293 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002277 C00002293 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002277 C00002293 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002277 C00002293 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002277 C00002293 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002277 C00002293 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002277 C00002293 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002277 C00002293 | 0 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00002305 C00025552 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002277 C00002293 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002277 C00002293 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002277 C00002293 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002277 C00002293 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002277 C00002293 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002277 C00002293 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002277 C00002293 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002277 C00002293 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002277 C00002293 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002277 C00002293 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002277 C00002293 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002277 C00002293 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002277 C00002293 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002277 C00002293 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 0 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002277 C00002293 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002277 C00002293 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002277 C00002293 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002277 C00002293 | 1 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002277 C00002293 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002277 C00002293 | 0 / 3 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002277 C00002293 | 2 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002277 C00002293 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002277 C00002293 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002277 C00002293 | 5 / 9 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002277 C00002293 | 0 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002277 C00002293 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002277 C00002293 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002277 C00002293 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002277 C00002293 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00002305 C00025552 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002277 C00002293 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002277 C00002293 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002277 C00002293 | 2 / 1 |
| P17252 | Protein kinase C alpha type | Alpha | C00002277 C00002293 | 0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00002277 C00002293 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002277 C00002293 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002277 C00002293 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002277 C00002293 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 1 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002277 C00002293 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002277 C00002293 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002277 C00002293 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002277 C00002293 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002277 C00002293 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002277 C00002293 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002277 C00002293 | 2 / 2 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002277 C00002293 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002277 C00002293 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002277 C00002293 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002277 C00002293 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002277 C00002293 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002277 C00002293 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002277 C00002293 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002277 C00002293 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002277 C00002293 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002277 C00002293 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002277 C00002293 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002277 C00002293 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002277 C00002293 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002277 C00002293 | 2 / 1 |
| O00255 | Menin | Unclassified protein | C00002277 C00002293 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002277 C00002293 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002277 C00002293 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002277 C00002293 | 1 / 4 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002277 C00002293 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002292 | 3 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002286 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002292 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00002292 | 1 / 0 |
47 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1066 | CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 | carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) |
C00002277
C00002305
|
| 3760 | KCNJ3, GIRK1, KGA, KIR3.1 | potassium inwardly-rectifying channel, subfamily J, member 3 |
C00002277
C00002292
|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00002277
C00002292
|
| 2914 | GRM4, GPRC1D, MGLUR4, mGlu4 | glutamate receptor, metabotropic 4 |
C00002277
C00002292
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00002277
C00002292
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00002277
C00002292
|
| 7430 | EZR, CVIL, CVL, VIL2 | ezrin |
C00002277
|
| 9134 | CCNE2, CYCE2 | cyclin E2 |
C00002277
|
| 958 | CD40, Bp50, CDW40, TNFRSF5, p50 | CD40 molecule, TNF receptor superfamily member 5 |
C00002277
|
| 991 | CDC20, CDC20A, bA276H19.3, p55CDC | cell division cycle 20 |
C00002277
|
| 990 | CDC6, CDC18L, HsCDC18, HsCDC6 | cell division cycle 6 |
C00002277
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00002277
|
| 1128 | CHRM1, HM1, M1, M1R | cholinergic receptor, muscarinic 1 |
C00002277
|
| 1129 | CHRM2, HM2 | cholinergic receptor, muscarinic 2 |
C00002277
|
| 1131 | CHRM3, EGBRS, HM3 | cholinergic receptor, muscarinic 3 |
C00002277
|
| 1132 | CHRM4, HM4, M4R | cholinergic receptor, muscarinic 4 |
C00002277
|
| 896 | CCND3 | cyclin D3 |
C00002277
|
| 8900 | CCNA1 | cyclin A1 |
C00002277
|
| 1392 | CRH, CRF | corticotropin releasing hormone |
C00002277
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00002277
|
| 1856 | DVL2 | dishevelled segment polarity protein 2 |
C00002277
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00002277
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00002277
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002277
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00002277
|
| 2741 | GLRA1, HKPX1, STHE | glycine receptor, alpha 1 |
C00002277
|
| 9564 | BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas | breast cancer anti-estrogen resistance 1 |
C00002277
|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002277
|
| 3815 | KIT, C-Kit, CD117, PBT, SCFR | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (EC:2.7.10.1) |
C00002277
|
| 4057 | LTF, GIG12, HLF2, LF | lactotransferrin |
C00002277
|
| 4173 | MCM4, CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21 | minichromosome maintenance complex component 4 (EC:3.6.4.12) |
C00002277
|
| 4175 | MCM6, MCG40308, Mis5, P105MCM | minichromosome maintenance complex component 6 (EC:3.6.4.12) |
C00002277
|
| 4855 | NOTCH4, INT3, NOTCH3 | notch 4 |
C00002277
|
| 5111 | PCNA | proliferating cell nuclear antigen |
C00002277
|
| 5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) |
C00002277
|
| 5829 | PXN | paxillin |
C00002277
|
| 5881 | RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
C00002277
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00002277
|
| 6580 | SLC22A1, HOCT1, OCT1, oct1_cds | solute carrier family 22 (organic cation transporter), member 1 |
C00002277
|
| 6582 | SLC22A2, OCT2 | solute carrier family 22 (organic cation transporter), member 2 |
C00002277
|
| 6581 | SLC22A3, EMT, EMTH, OCT3 | solute carrier family 22 (organic cation transporter), member 3 |
C00002277
|
| 6583 | SLC22A4, OCTN1 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 |
C00002277
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002277
|
| 7204 | TRIO, ARHGEF23, tgat | trio Rho guanine nucleotide exchange factor (EC:2.7.11.1) |
C00002277
|
| 183 | AGT, ANHU, SERPINA8 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
C00002292
|
| 1103 | CHAT, CHOACTASE, CMS1A, CMS1A2 | choline O-acetyltransferase (EC:2.3.1.6) |
C00002292
|
| 4012 | LNPEP, CAP, IRAP, P-LAP, PLAP | leucyl/cystinyl aminopeptidase (EC:3.4.11.3) |
C00002292
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (64)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
Diseases related to CTD interactions
142 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00002277
C00002292 |
| D014987 | Xerostomia |
C00002277
C00002292 |
| D014839 | Vomiting |
C00002277
C00002292 |
| D014786 | Vision Disorders |
C00002277
C00002292 |
| D014202 | Tremor |
C00002277
C00002292 |
| D013610 | Tachycardia |
C00002277
C00002292 |
| D013375 | Substance Withdrawal Syndrome |
C00002277
C00002292 |
| D053608 | Stupor |
C00002277
C00002292 |
| D013226 | Status Epilepticus |
C00002277
C00002292 |
| D012640 | Seizures |
C00002277
C00002292 |
| D001919 | Bradycardia |
C00002277
C00002292 |
| D012021 | Reflex, Abnormal |
C00002277
C00002292 |
| D020250 | Postoperative Nausea and Vomiting |
C00002277
C00002292 |
| D002375 | Catalepsy |
C00002277
C00002292 |
| D011183 | Postoperative Complications |
C00002277
C00002292 |
| D009325 | Nausea |
C00002277
C00002292 |
| D009203 | Myocardial Infarction |
C00002277
C00002292 |
| D019970 | Cocaine-Related Disorders |
C00002277
C00002292 |
| D003128 | COMA |
C00002277
C00002292 |
| D015878 | Mydriasis |
C00002277
C00002292 |
| D009127 | Muscle Rigidity |
C00002277
C00002292 |
| D003693 | Delirium |
C00002277
C00002292 |
| D007859 | Learning Disorders |
C00002277
C00002292 |
| D056486 | Drug-Induced Liver Injury |
C00002277
C00002292 |
| D062787 | Drug Overdose |
C00002277
C00002292 |
| D007035 | Hypothermia |
C00002277
C00002292 |
| D006973 | Hypertension |
C00002277
C00002292 |
| D006327 | Heart Block |
C00002277
C00002292 |
| D006212 | Hallucinations |
C00002277
C00002292 |
| D004827 | Epilepsy |
C00002277
|
| D004830 | Epilepsy, Tonic-Clonic |
C00002277
|
| D007172 | Erectile Dysfunction |
C00002277
|
| D005334 | Fever |
C00002277
|
| D005483 | Flushing |
C00002277
|
| D005767 | Gastrointestinal Diseases |
C00002277
|
| D004831 | Epilepsies, Myoclonic |
C00002277
|
| D006261 | Headache |
C00002277
|
| D006323 | Heart Arrest |
C00002277
|
| D020820 | Dyskinesias |
C00002277
|
| D006342 | Heart Rupture, Post-Infarction |
C00002277
|
| D006940 | Hyperemia |
C00002277
|
| D006943 | Hyperglycemia |
C00002277
|
| D004381 | Duodenal Ulcer |
C00002277
|
| D007008 | Hypokalemia |
C00002277
|
| D007022 | Hypotension |
C00002277
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00002277
|
| D007249 | Inflammation |
C00002277
|
| D007410 | Intestinal Diseases |
C00002277
|
| D003967 | Diarrhea |
C00002277
|
| D008133 | Long QT Syndrome |
C00002277
|
| D015877 | Miosis |
C00002277
|
| D006259 | Craniocerebral Trauma |
C00002277
|
| D018908 | Muscle Weakness |
C00002277
|
| D009135 | Muscular Diseases |
C00002277
|
| D009140 | Musculoskeletal Diseases |
C00002277
|
| D009157 | Myasthenia Gravis |
C00002277
|
| D003329 | Coronary Vasospasm |
C00002277
|
| D002637 | Chest Pain |
C00002277
|
| D017202 | Myocardial Ischemia |
C00002277
|
| D009207 | Myoclonus |
C00002277
|
| D009216 | Myopia |
C00002277
|
| D002561 | Cerebrovascular Disorders |
C00002277
|
| D009336 | Necrosis |
C00002277
|
| D009422 | Nervous System Diseases |
C00002277
|
| D020258 | Neurotoxicity Syndromes |
C00002277
|
| D062025 | Organophosphate Poisoning |
C00002277
|
| D010243 | Paralysis |
C00002277
|
| D010437 | Peptic Ulcer |
C00002277
|
| D010554 | Personality Disorders |
C00002277
|
| D011041 | Poisoning |
C00002277
|
| D002385 | Cataplexy |
C00002277
|
| D001982 | Bronchial Diseases |
C00002277
|
| D011297 | Prenatal Exposure Delayed Effects |
C00002277
|
| D011654 | Pulmonary Edema |
C00002277
|
| D001943 | Breast Neoplasms |
C00002277
|
| D012120 | Respiration Disorders |
C00002277
|
| D012131 | Respiratory Insufficiency |
C00002277
|
| D054537 | Atrioventricular Block |
C00002277
|
| D054138 | Sinus Arrest, Cardiac |
C00002277
|
| D001281 | Atrial Fibrillation |
C00002277
|
| D013276 | Stomach Ulcer |
C00002277
|
| D001146 | Arrhythmia, Sinus |
C00002277
|
| D001145 | Arrhythmias, Cardiac |
C00002277
|
| D013575 | Syncope |
C00002277
|
| D001049 | Apnea |
C00002277
|
| D013611 | Tachycardia, Atrioventricular Nodal Reentry |
C00002277
|
| D013616 | Tachycardia, Sinus |
C00002277
|
| D013617 | Tachycardia, Supraventricular |
C00002277
|
| D017180 | Tachycardia, Ventricular |
C00002277
|
| D016171 | Torsades de Pointes |
C00002277
|
| D056988 | Anterior Wall Myocardial Infarction |
C00002277
|
| D053201 | Urinary Bladder, Overactive |
C00002277
|
| D014555 | Urination Disorders |
C00002277
|
| D014607 | Uveomeningoencephalitic Syndrome |
C00002277
|
| D020421 | Vagus Nerve Diseases |
C00002277
|
| D014693 | Ventricular Fibrillation |
C00002277
|
| D000855 | Anorexia |
C00002277
|
| D000787 | Angina Pectoris |
C00002277
|
| D020236 | Amnesia, Transient Global |
C00002277
|
| D020324 | Amnesia, Anterograde |
C00002292
|
| D000648 | Amnesia, Retrograde |
C00002292
|
| D015875 | Anisocoria |
C00002292
|
| D001037 | Aphasia |
C00002292
|
| D001072 | Apraxias |
C00002292
|
| D001259 | Ataxia |
C00002292
|
| D001927 | Brain Diseases |
C00002292
|
| D001930 | Brain Injuries |
C00002292
|
| D002389 | Catatonia |
C00002292
|
| D003072 | Cognition Disorders |
C00002292
|
| D003221 | Confusion |
C00002292
|
| D003704 | Dementia |
C00002292
|
| D004195 | Disease Models, Animal |
C00002292
|
| D006970 | Disorders of Excessive Somnolence |
C00002292
|
| D004244 | Dizziness |
C00002292
|
| D015352 | Dry Eye Syndromes |
C00002292
|
| D004401 | Dysarthria |
C00002292
|
| D004409 | Dyskinesia, Drug-Induced |
C00002292
|
| D004948 | Esotropia |
C00002292
|
| D005402 | Fistula |
C00002292
|
| D006948 | Hyperkinesis |
C00002292
|
| D018476 | Hypokinesia |
C00002292
|
| D007634 | Keratitis |
C00002292
|
| D007638 | Keratoconjunctivitis Sicca |
C00002292
|
| D008103 | Liver Cirrhosis |
C00002292
|
| D055370 | Lung Injury |
C00002292
|
| D008569 | Memory Disorders |
C00002292
|
| D020326 | Migraine without Aura |
C00002292
|
| D009041 | Motion Sickness |
C00002292
|
| D009069 | Movement Disorders |
C00002292
|
| D009410 | Nerve Degeneration |
C00002292
|
| D009293 | Opioid-Related Disorders |
C00002292
|
| D010259 | Paranoid Disorders |
C00002292
|
| D020795 | Photophobia |
C00002292
|
| D011595 | Psychomotor Agitation |
C00002292
|
| D011596 | Psychomotor Disorders |
C00002292
|
| D011605 | Psychoses, Substance-Induced |
C00002292
|
| D011681 | Pupil Disorders |
C00002292
|
| D012798 | Sialorrhea |
C00002292
|
| D005879 | Tourette Syndrome |
C00002292
|
| D014549 | Urinary Incontinence |
C00002292
|
| D015431 | Weight Loss |
C00002292
|
| D014985 | Xerophthalmia |
C00002292
|