Species

KNApSAcK Entry

Organism name Brucea sumatrana
Genus Brucea
Family Simaroubaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Brucea
Linked NCBI taxonomy ID 43722
Linked level genus

Family

Family in NCBI taxonomy Simaroubaceae
ID 23808

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003702 External link 512 Bruceine D
CHEMBL477693
C030412
No. 432 No. 51
C00003704 External link 512 Brusatol
CHEMBL450464
CHEMBL1702665
C020237
9 / 15 / 8 2 / 0 No. 2130 No. 51

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00003704 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003704 2 / 0
P37840 Alpha-synuclein Unclassified protein C00003704 4 / 2
O75496 Geminin Unclassified protein C00003704 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003704 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00003704 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003704 0 / 0
P05412 Transcription factor AP-1 Transcription Factor C00003704 0 / 0
Q06710 Paired box protein Pax-8 Unclassified protein C00003704 1 / 2

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9817 KEAP1, INrf2, KLHL19 kelch-like ECH-associated protein 1 C00003704
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00003704

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#127750 Dementia, lewy body; dlb P37840
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (8)

KEGG name UniProt
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00032 Thyroid cancer Q06710 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) Q06710 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)