Species

KNApSAcK Entry

Organism name Primula veris
Genus Primula
Family Primulaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Primula veris
Linked NCBI taxonomy ID 170927
Linked level species

Family

Family in NCBI taxonomy Primulaceae
ID 4335

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005588 External link 512 Isorhamnetin 3-rhamnosyl-(1->2)-[rhamnosyl-(1->6)-galactoside]-7-rhamnoside
No. 5 No. 15
C00005568 External link 512 Isorhamnetin 3-rhamnosyl-(1->2)-[rhamnosyl-(1->6)-galactoside]
CHEMBL450526
No. 5 No. 15
C00003857 External link 512 Zapotin
/ 5,6,2',6'-Tetramethoxyflavone
/ 2-(2,6-Dimethoxyphenyl)-5,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL375582
1 / 0 / 0 No. 8 No. 15
C00035491 External link 512 3'-Methoxy-4',5'-methylenedioxyflavone
No. 27 No. 15
C00013299 External link 512 3',4',5'-Trimethoxyflavone
/ 2-(3,4,5-Trimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL307856
16 / 7 / 3 No. 35 No. 15
C00035474 External link 512 2',5'-Dimethoxyflavone
No. 35 No. 15
C00035490 External link 512 3'-Hydroxy-4',5'-dimethoxyflavone
No. 35 No. 15
C00035488 External link 512 3',4'-Dimethoxyflavone
CHEMBL91153
15 / 21 / 19 No. 35 No. 15
C00003791 External link 512 2'-Hydroxyflavone
CHEMBL144278
C056011
No. 76 No. 15
C00035482 External link 512 2'-Methoxyflavone
CHEMBL147722
No. 76 No. 15
C00035492 External link 512 3'-Methoxyflavone
CHEMBL342343
No. 76 No. 15

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein C00035488 4 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00035488 3 / 1
P08183 Multidrug resistance protein 1 drug C00035488 1 / 0
P11926 Ornithine decarboxylase Lyase C00003857 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00035488 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00035488 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00035488 0 / 0
P06280 Alpha-galactosidase A Enzyme C00035488 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00035488 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00035488 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00035488 2 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00035488 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00035488 4 / 3
P06239 Tyrosine-protein kinase Lck Src C00013299 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00035488 0 / 0
O00255 Menin Unclassified protein C00035488 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00035488 1 / 2
Q13748 Tubulin alpha-3C/D chain Structural C00013299 0 / 0
P68366 Tubulin alpha-4A chain Structural C00013299 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00013299 1 / 0
P04350 Tubulin beta-4A chain Structural C00013299 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00013299 0 / 0
P07437 Tubulin beta chain Structural C00013299 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00013299 1 / 1
P68371 Tubulin beta-4B chain Structural C00013299 0 / 0
Q13509 Tubulin beta-3 chain Structural C00013299 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00013299 0 / 0
Q13885 Tubulin beta-2A chain Structural C00013299 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00013299 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00013299 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00013299 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00013299 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#119900 Digital clubbing, isolated congenital P15428
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#301500 Fabry disease P06280
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#612244 Inflammatory bowel disease 13; ibd13 P08183
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (22)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)