Heracleum dissectum
Species
KNApSAcK Entry
| Organism name | Heracleum dissectum |
|---|---|
| Genus | Heracleum |
| Family | Apiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Heracleum dissectum |
|---|---|
| Linked NCBI taxonomy ID | 380073 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00022705
|
7-Isopentenyloxycoumarin
|
CHEMBL156692
|
9 / 1 / 2 | No. 466 | No. 25 |
|
||
|
C00000583
|
Isopimpinellin
|
CHEMBL140796
|
C015304
|
9 / 3 / 4 | 2 / 0 | No. 606 | No. 25 |
|
|
C00002493
|
Pimpinellin
|
CHEMBL1491809
|
C039409
|
3 / 0 / 1 | No. 606 | No. 25 |
|
|
|
C00002477
|
Imperatorin
|
CHEMBL453805
|
C031534
|
18 / 7 / 6 | 1 / 1 | No. 606 | No. 25 |
|
|
C00002503
|
Umbelliferon
/ Umbelliferone / 7-Hydroxycoumarin |
CHEMBL51628
|
C031477
|
39 / 33 / 32 | 9 / 0 | No. 1030 | No. 25 |
|
|
C00000575
|
Bergaptan
|
CHEMBL24171
|
C022909
|
22 / 22 / 17 | 0 / 3 | No. 1282 | No. 25 |
|
|
C00037321
|
Isobergapten
|
CHEMBL141690
|
8 / 5 / 4 | No. 1282 | No. 25 |
|
Human Protein / Gene in interactions
76 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000575 C00002477 C00002493 C00002503 C00022705 C00037321 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000575 C00000583 C00002503 C00022705 C00037321 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000575 C00000583 C00002477 C00002503 C00022705 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000575 C00000583 C00002477 C00002493 C00037321 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000575 C00002477 C00002503 C00022705 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000575 C00000583 C00022705 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000575 C00002503 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000583 C00002503 | 2 / 2 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000583 C00002477 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002477 C00037321 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002477 C00037321 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002477 C00002503 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002477 C00037321 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00002503 C00037321 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000583 C00002503 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000583 C00002477 | 1 / 1 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00022705 | 1 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002503 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002503 | 1 / 2 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002477 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00002477 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00000575 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000575 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002477 | 2 / 3 |
| P16389 | Potassium voltage-gated channel subfamily A member 2 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
| P17658 | Potassium voltage-gated channel subfamily A member 6 | K | C00000575 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00002503 | 1 / 1 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002503 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000575 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002503 | 0 / 0 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000575 | 1 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002503 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002503 | 0 / 0 |
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Oxidoreductase | C00002503 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002503 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002503 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002477 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000575 | 7 / 3 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000575 | 3 / 2 |
| P29466 | Caspase-1 | C14 | C00002503 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002503 | 6 / 4 |
| P14679 | Tyrosinase | Oxidoreductase | C00002503 | 4 / 2 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002503 | 1 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00022705 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00002477 | 0 / 0 |
| P22001 | Potassium voltage-gated channel subfamily A member 3 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002503 | 0 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00000583 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002503 | 0 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00022705 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002503 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002503 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002503 | 1 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002503 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002493 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002503 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000575 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002477 | 2 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00022705 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002477 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002503 | 1 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002503 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00037321 | 4 / 3 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002503 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000575 | 3 / 4 |
| P22460 | Potassium voltage-gated channel subfamily A member 5 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00002503 | 1 / 1 |
| P48547 | Potassium voltage-gated channel subfamily C member 1 | K | C00000575 | 0 / 0 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00002477 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002503 | 3 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002503 | 1 / 1 |
| Q09470 | Potassium voltage-gated channel subfamily A member 1 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00002503 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002503 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002503 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000575 | 1 / 0 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000583
C00002477
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002503
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00002503
|
| 8574 | AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) |
C00002503
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002503
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000583
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002503
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002503
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002503
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002503
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002503
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (63)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #612240 | Atrial fibrillation, familial, 7; atfb7 |
P22460
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #160120 | Episodic ataxia, type 1; ea1 |
Q09470
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (53)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
P11308 (related) |
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00731 | Atrial fibrillation |
P22460
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00749 | Episodic ataxias |
Q09470
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|