Species

KNApSAcK Entry

Organism name Heracleum dissectum
Genus Heracleum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Heracleum dissectum
Linked NCBI taxonomy ID 380073
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00022705 External link 512 7-Isopentenyloxycoumarin
CHEMBL156692
9 / 1 / 2 No. 466 No. 25
C00000583 External link 512 Isopimpinellin
CHEMBL140796
C015304
9 / 3 / 4 2 / 0 No. 606 No. 25
C00002493 External link 512 Pimpinellin
CHEMBL1491809
C039409
3 / 0 / 1 No. 606 No. 25
C00002477 External link 512 Imperatorin
CHEMBL453805
C031534
18 / 7 / 6 1 / 1 No. 606 No. 25
C00002503 External link 512 Umbelliferon
/ Umbelliferone
/ 7-Hydroxycoumarin
CHEMBL51628
C031477
39 / 33 / 32 9 / 0 No. 1030 No. 25
C00000575 External link 512 Bergaptan
CHEMBL24171
C022909
22 / 22 / 17 0 / 3 No. 1282 No. 25
C00037321 External link 512 Isobergapten
CHEMBL141690
8 / 5 / 4 No. 1282 No. 25

Human Protein / Gene in interactions

76 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00000575 C00002477 C00002493 C00002503 C00022705 C00037321 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000575 C00000583 C00002503 C00022705 C00037321 0 / 0
P56817 Beta-secretase 1 A1A C00000575 C00000583 C00002477 C00002503 C00022705 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000575 C00000583 C00002477 C00002493 C00037321 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000575 C00002477 C00002503 C00022705 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000575 C00000583 C00022705 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000575 C00002503 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000583 C00002503 2 / 2
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000583 C00002477 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002477 C00037321 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002477 C00037321 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002477 C00002503 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002477 C00037321 1 / 0
O75496 Geminin Unclassified protein C00002503 C00037321 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000583 C00002503 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000583 C00002477 1 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00022705 1 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002503 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002503 1 / 2
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002477 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00002477 0 / 0
P08183 Multidrug resistance protein 1 drug C00000575 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000575 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00002477 2 / 3
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P17658 Potassium voltage-gated channel subfamily A member 6 K C00000575 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00002503 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00002503 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000575 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002503 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000575 1 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002503 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002503 0 / 0
P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Oxidoreductase C00002503 0 / 0
P15121 Aldose reductase Enzyme C00002503 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002503 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002477 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000575 7 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00000575 3 / 2
P29466 Caspase-1 C14 C00002503 0 / 0
P04062 Glucosylceramidase Enzyme C00002503 6 / 4
P14679 Tyrosinase Oxidoreductase C00002503 4 / 2
P06280 Alpha-galactosidase A Enzyme C00002503 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00022705 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00002477 0 / 0
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00000575 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002503 0 / 1
P06746 DNA polymerase beta Enzyme C00000583 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002503 0 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00022705 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002503 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002503 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002503 1 / 0
Q00796 Sorbitol dehydrogenase Enzyme C00002503 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002493 0 / 0
P55210 Caspase-7 C14 C00002503 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000575 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002477 2 / 0
Q9UNA4 DNA polymerase iota Enzyme C00022705 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002477 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002503 1 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002503 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00037321 4 / 3
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002503 0 / 0
P10275 Androgen receptor NR3C4 C00000575 3 / 4
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA, Kv1.x (Shaker) C00000575 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00002503 1 / 1
P48547 Potassium voltage-gated channel subfamily C member 1 K C00000575 0 / 0
O00167 Eyes absent homolog 2 Enzyme C00002477 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002503 3 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002503 1 / 1
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000575 1 / 1
O00255 Menin Unclassified protein C00002503 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002503 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002503 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000575 1 / 0

11 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000583 C00002477
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002503
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00002503
8574 AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) C00002503
581 BAX, BCL2L4 BCL2-associated X protein C00002503
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000583
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002503
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002503
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002503
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002503
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002503

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (63)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#612240 Atrial fibrillation, familial, 7; atfb7 P22460
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#160120 Episodic ataxia, type 1; ea1 Q09470
#612219 Ewing sarcoma; es P11308
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (53)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00731 Atrial fibrillation P22460 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00749 Episodic ataxias Q09470 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006505 Hepatitis C00000575
D010787 Photosensitivity Disorders C00000575
D011565 Psoriasis C00000575
D056486 Drug-Induced Liver Injury C00002477