Ligusticum multivittatum
Species
KNApSAcK Entry
| Organism name | Ligusticum multivittatum |
|---|---|
| Genus | Ligusticum |
| Family | Apiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ligusticum |
|---|---|
| Linked NCBI taxonomy ID | 49551 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002477
|
Imperatorin
|
CHEMBL453805
|
C031534
|
18 / 7 / 6 | 1 / 1 | No. 606 | No. 25 |
|
|
C00000583
|
Isopimpinellin
|
CHEMBL140796
|
C015304
|
9 / 3 / 4 | 2 / 0 | No. 606 | No. 25 |
|
|
C00001283
|
Falcarindiol
|
CHEMBL69018
CHEMBL1094112 |
C034379
|
3 / 0 / 0 | No. 940 | No. 69 |
|
|
|
C00002503
|
Umbelliferon
/ Umbelliferone / 7-Hydroxycoumarin |
CHEMBL51628
|
C031477
|
39 / 33 / 32 | 9 / 0 | No. 1030 | No. 25 |
|
|
C00000576
|
Xanthotoxin
|
CHEMBL416
|
D008730
|
104 / 55 / 45 | 22 / 18 | No. 1282 | No. 25 |
|
|
C00000575
|
Bergaptan
|
CHEMBL24171
|
C022909
|
22 / 22 / 17 | 0 / 3 | No. 1282 | No. 25 |
|
|
C00002450
|
Angelicin
|
CHEMBL53569
|
C011659
|
2 / 0 / 0 | 0 / 3 | No. 1282 | No. 25 |
|
|
C00002743
|
Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid |
CHEMBL32749
|
C004999
|
110 / 52 / 40 | 16 / 6 | No. 1366 | No. 6 |
|
Human Protein / Gene in interactions
166 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P56817 | Beta-secretase 1 | A1A | C00000575 C00000576 C00000583 C00002450 C00002477 C00002503 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000575 C00000576 C00000583 C00002477 C00002743 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000575 C00000576 C00002477 C00002503 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000575 C00000583 C00002503 C00002743 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000575 C00002477 C00002503 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000575 C00000576 C00002743 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000575 C00000576 C00002743 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000575 C00000576 C00002743 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000576 C00002503 C00002743 | 1 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000576 C00001283 C00002743 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000576 C00002503 C00002743 | 0 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000576 C00001283 C00002743 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000575 C00000576 C00002743 | 0 / 1 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001283 C00002477 C00002743 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000576 C00002503 C00002743 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000576 C00002503 C00002743 | 1 / 2 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000576 C00000583 C00002477 | 1 / 1 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000576 C00002743 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 0 / 0 |
| Q09470 | Potassium voltage-gated channel subfamily A member 1 | KCNA, Kv1.x (Shaker) | C00000575 C00000576 | 1 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002477 C00002503 | 1 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000576 C00002743 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000576 C00002743 | 0 / 1 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000576 C00002743 | 1 / 1 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000576 C00002743 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000576 C00002743 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000576 C00002743 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000576 C00002743 | 2 / 2 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000575 C00000576 | 1 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000575 C00000576 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002503 C00002743 | 1 / 1 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000576 C00002743 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000576 C00002743 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000576 C00002743 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000576 C00002743 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000576 C00002743 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000576 C00002743 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000576 C00002743 | 1 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000576 C00002743 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000575 C00000576 | 3 / 4 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000575 C00000583 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000576 C00002743 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000576 C00002743 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000576 C00002743 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00000576 C00002743 | 2 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002503 C00002743 | 5 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000576 C00002743 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000576 C00002477 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000576 C00002743 | 2 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000576 C00002743 | 2 / 2 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000576 C00002743 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000576 C00002743 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000576 C00002743 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000576 C00002743 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000583 C00002477 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000576 C00002743 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000576 C00002743 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000576 C00002743 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000576 C00002743 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000576 C00002743 | 1 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002503 C00002743 | 3 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000576 C00002743 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000576 C00002743 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002503 C00002743 | 1 / 2 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000576 C00002743 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000576 C00002743 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000576 C00002743 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000583 C00002503 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002503 C00002743 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002503 C00002743 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000576 C00002743 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000576 C00002743 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000576 C00002743 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000576 C00002743 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000576 C00002743 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000576 C00002743 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000576 C00002743 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000576 C00002743 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000576 C00002743 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000576 C00002743 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000576 C00002743 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000576 C00002743 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002503 C00002743 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000576 C00002743 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000576 C00002743 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000576 C00002743 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000576 C00002477 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000576 C00002743 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000576 C00002743 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000575 C00000576 | 7 / 3 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000576 C00002743 | 1 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000576 C00002743 | 1 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000576 C00002743 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000576 C00002743 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000576 C00002743 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000576 C00002743 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00002503 C00002743 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000576 C00002743 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000576 C00002743 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000576 C00002743 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000576 C00002743 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000576 C00002743 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000576 C00002743 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000576 C00002743 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000576 C00002743 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000583 C00002503 | 2 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000575 C00002503 | 3 / 3 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000576 C00002743 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000576 C00002743 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000576 C00002743 | 2 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002503 C00002743 | 0 / 1 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000576 C00002743 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000576 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00002477 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002503 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000576 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002503 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002503 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002477 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00000576 | 1 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002503 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00000576 | 1 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002503 | 0 / 0 |
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Oxidoreductase | C00002503 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002503 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00002743 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002503 | 1 / 1 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00002503 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002477 | 2 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002503 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00002450 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002503 | 0 / 0 |
| P48547 | Potassium voltage-gated channel subfamily C member 1 | K | C00000575 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002743 | 0 / 0 |
| P16389 | Potassium voltage-gated channel subfamily A member 2 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002477 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002743 | 0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00000576 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00000575 | 1 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00002477 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002743 | 3 / 0 |
| P17658 | Potassium voltage-gated channel subfamily A member 6 | K | C00000575 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002503 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000583 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002743 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002743 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002743 | 0 / 0 |
| P22460 | Potassium voltage-gated channel subfamily A member 5 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002743 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002743 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00002503 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00002743 | 1 / 2 |
| P04062 | Glucosylceramidase | Enzyme | C00002503 | 6 / 4 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00002477 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002477 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002503 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002477 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00002503 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002503 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002503 | 0 / 0 |
| P22001 | Potassium voltage-gated channel subfamily A member 3 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
41 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000576
C00002503
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002503
C00002743
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00000576
C00002503
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000576
C00002743
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000576
C00002743
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000576
C00002503
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000576
C00000583
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000583
C00002477
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00000576
C00002743
|
| 23621 | BACE1, ASP2, BACE, HSPC104 | beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) |
C00002743
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00002743
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002743
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002743
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002743
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002743
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002743
|
| 5742 | PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002743
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00002503
|
| 8574 | AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) |
C00002503
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002743
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002743
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002503
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002503
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002503
|
| 8553 | BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 | basic helix-loop-helix family, member e40 |
C00000576
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00000576
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000576
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000576
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000576
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00000576
|
| 8824 | CES2, CE-2, CES2A1, PCE-2, iCE | carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) |
C00000576
|
| 1553 | CYP2A13, CPAD, CYP2A, CYPIIA13 | cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) |
C00000576
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000576
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00000576
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000576
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00000576
|
| 3355109 |
C00000576
|
||
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000576
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000576
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (95)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #612240 | Atrial fibrillation, familial, 7; atfb7 |
P22460
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #160120 | Episodic ataxia, type 1; ea1 |
Q09470
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (75)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00731 | Atrial fibrillation |
P22460
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00749 | Episodic ataxias |
Q09470
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
27 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D056486 | Drug-Induced Liver Injury |
C00002450
C00002477 C00000576 |
| D011565 | Psoriasis |
C00000575
C00000576 |
| D010787 | Photosensitivity Disorders |
C00002450
C00000575 |
| D006261 | Headache |
C00000576
|
| D008545 | Melanoma |
C00002743
|
| D009203 | Myocardial Infarction |
C00002743
|
| D000647 | Amnesia |
C00002450
|
| D050197 | Atherosclerosis |
C00002743
|
| D007249 | Inflammation |
C00002743
|
| D006505 | Hepatitis |
C00000575
|
| D002252 | Carbon Tetrachloride Poisoning |
C00002743
|
| D015746 | Abdominal Pain |
C00000576
|
| D004485 | Eczema |
C00000576
|
| D008106 | Liver Cirrhosis, Experimental |
C00002743
|
| D007674 | Kidney Diseases |
C00000576
|
| D017114 | Liver Failure, Acute |
C00000576
|
| D008175 | Lung Neoplasms |
C00000576
|
| D016410 | Lymphoma, T-Cell, Cutaneous |
C00000576
|
| D008881 | Migraine Disorders |
C00000576
|
| D009182 | Mycosis Fungoides |
C00000576
|
| D009325 | Nausea |
C00000576
|
| D000857 | Olfaction Disorders |
C00000576
|
| D011693 | Purpura |
C00000576
|
| D007319 | Sleep Initiation and Maintenance Disorders |
C00000576
|
| D014006 | Tinea Capitis |
C00000576
|
| D015837 | Vestibular Diseases |
C00000576
|
| D014820 | Vitiligo |
C00000576
|