Species

KNApSAcK Entry

Organism name Ligusticum multivittatum
Genus Ligusticum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ligusticum
Linked NCBI taxonomy ID 49551
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002477 External link 512 Imperatorin
CHEMBL453805
C031534
18 / 7 / 6 1 / 1 No. 606 No. 25
C00000583 External link 512 Isopimpinellin
CHEMBL140796
C015304
9 / 3 / 4 2 / 0 No. 606 No. 25
C00001283 External link 512 Falcarindiol
CHEMBL69018
CHEMBL1094112
C034379
3 / 0 / 0 No. 940 No. 69
C00002503 External link 512 Umbelliferon
/ Umbelliferone
/ 7-Hydroxycoumarin
CHEMBL51628
C031477
39 / 33 / 32 9 / 0 No. 1030 No. 25
C00000576 External link 512 Xanthotoxin
CHEMBL416
D008730
104 / 55 / 45 22 / 18 No. 1282 No. 25
C00000575 External link 512 Bergaptan
CHEMBL24171
C022909
22 / 22 / 17 0 / 3 No. 1282 No. 25
C00002450 External link 512 Angelicin
CHEMBL53569
C011659
2 / 0 / 0 0 / 3 No. 1282 No. 25
C00002743 External link 512 Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
CHEMBL32749
C004999
110 / 52 / 40 16 / 6 No. 1366 No. 6

Human Protein / Gene in interactions

166 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A C00000575 C00000576 C00000583 C00002450 C00002477 C00002503 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000575 C00000576 C00000583 C00002477 C00002743 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000575 C00000576 C00002477 C00002503 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000575 C00000583 C00002503 C00002743 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000575 C00002477 C00002503 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000575 C00000576 C00002743 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000575 C00000576 C00002743 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000575 C00000576 C00002743 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000576 C00002503 C00002743 1 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000576 C00001283 C00002743 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000576 C00002503 C00002743 0 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000576 C00001283 C00002743 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000575 C00000576 C00002743 0 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00001283 C00002477 C00002743 0 / 0
P29466 Caspase-1 C14 C00000576 C00002503 C00002743 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000576 C00002503 C00002743 1 / 2
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000576 C00000583 C00002477 1 / 1
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000576 C00002743 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000576 C00002743 0 / 0
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000575 C00000576 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00002477 C00002503 1 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000576 C00002743 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000576 C00002743 0 / 1
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000576 C00002743 1 / 1
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000576 C00002743 0 / 0
P17252 Protein kinase C alpha type Alpha C00000576 C00002743 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000576 C00002743 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000576 C00002743 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000576 C00002743 2 / 2
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000575 C00000576 1 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000576 C00002743 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000575 C00000576 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002503 C00002743 1 / 1
Q16539 Mitogen-activated protein kinase 14 p38 C00000576 C00002743 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000576 C00002743 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000576 C00002743 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000576 C00002743 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000576 C00002743 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000576 C00002743 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000576 C00002743 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000576 C00002743 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000576 C00002743 1 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00000576 C00002743 0 / 0
P10275 Androgen receptor NR3C4 C00000575 C00000576 3 / 4
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000575 C00000583 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000576 C00002743 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000576 C00002743 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000576 C00002743 0 / 0
P08246 Neutrophil elastase S1A C00000576 C00002743 2 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002503 C00002743 5 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000576 C00002743 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00000576 C00002477 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00000576 C00002743 2 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000576 C00002743 2 / 2
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000576 C00002743 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000576 C00002743 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000576 C00002743 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000576 C00002743 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000583 C00002477 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000576 C00002743 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000576 C00002743 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000576 C00002743 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000576 C00002743 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000576 C00002743 1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002503 C00002743 3 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000576 C00002743 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000576 C00002743 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002503 C00002743 1 / 2
P25103 Substance-P receptor Neurokinin receptor C00000576 C00002743 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000576 C00002743 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000576 C00002743 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000583 C00002503 0 / 0
O75496 Geminin Unclassified protein C00002503 C00002743 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002503 C00002743 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000576 C00002743 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000576 C00002743 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000576 C00002743 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000576 C00002743 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000576 C00002743 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000576 C00002743 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000576 C00002743 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000576 C00002743 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000576 C00002743 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000576 C00002743 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000576 C00002743 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000576 C00002743 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000576 C00002743 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00002503 C00002743 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000576 C00002743 0 / 0
P08311 Cathepsin G S1A C00000576 C00002743 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000576 C00002743 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000576 C00002477 0 / 0
P03956 Interstitial collagenase M10A C00000576 C00002743 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000576 C00002743 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000575 C00000576 7 / 3
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000576 C00002743 1 / 0
P03372 Estrogen receptor NR3A1 C00000576 C00002743 1 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000576 C00002743 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000576 C00002743 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000576 C00002743 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000576 C00002743 0 / 0
P14679 Tyrosinase Oxidoreductase C00002503 C00002743 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000576 C00002743 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000576 C00002743 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000576 C00002743 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000576 C00002743 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000576 C00002743 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000576 C00002743 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000576 C00002743 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000576 C00002743 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000583 C00002503 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000575 C00002503 3 / 3
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000576 C00002743 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000576 C00002743 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000576 C00002743 2 / 1
Q16790 Carbonic anhydrase 9 Lyase C00002503 C00002743 0 / 1
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000576 C00002743 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000576 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00002477 0 / 0
P06280 Alpha-galactosidase A Enzyme C00002503 1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000576 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002503 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002503 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002477 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000576 1 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002503 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000576 1 / 0
P15121 Aldose reductase Enzyme C00002503 0 / 0
P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Oxidoreductase C00002503 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002503 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00002743 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002503 1 / 1
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00002503 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002477 2 / 0
Q00796 Sorbitol dehydrogenase Enzyme C00002503 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002450 0 / 0
P55210 Caspase-7 C14 C00002503 0 / 0
P48547 Potassium voltage-gated channel subfamily C member 1 K C00000575 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002743 0 / 0
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00000575 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002477 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002743 0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 C00000576 0 / 0
P08183 Multidrug resistance protein 1 drug C00000575 1 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00002477 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002743 3 / 0
P17658 Potassium voltage-gated channel subfamily A member 6 K C00000575 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002503 0 / 0
P06746 DNA polymerase beta Enzyme C00000583 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002743 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00002743 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002743 0 / 0
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA, Kv1.x (Shaker) C00000575 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002743 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00002743 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00002503 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00002743 1 / 2
P04062 Glucosylceramidase Enzyme C00002503 6 / 4
O00167 Eyes absent homolog 2 Enzyme C00002477 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002477 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002503 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002477 1 / 0
O00255 Menin Unclassified protein C00002503 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002503 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002503 0 / 0
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00000575 0 / 0

41 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00000576 C00002503
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002503 C00002743
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00000576 C00002503
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000576 C00002743
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000576 C00002743
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000576 C00002503
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000576 C00000583
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000583 C00002477
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000576 C00002743
23621 BACE1, ASP2, BACE, HSPC104 beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) C00002743
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00002743
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002743
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002743
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002743
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002743
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002743
5742 PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002743
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00002503
8574 AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) C00002503
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002743
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002743
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002503
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002503
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002503
8553 BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 basic helix-loop-helix family, member e40 C00000576
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00000576
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000576
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000576
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000576
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000576
8824 CES2, CE-2, CES2A1, PCE-2, iCE carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) C00000576
1553 CYP2A13, CPAD, CYP2A, CYPIIA13 cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) C00000576
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000576
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00000576
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000576
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00000576
3355109 C00000576
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000576
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000576

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (95)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#600807 Asthma, susceptibility to Q13093
#612240 Atrial fibrillation, familial, 7; atfb7 P22460
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#160120 Episodic ataxia, type 1; ea1 Q09470
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168600 Parkinson disease, late-onset; pd P04062
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (75)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00731 Atrial fibrillation P22460 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00749 Episodic ataxias Q09470 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

27 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002450
C00002477
C00000576
D011565 Psoriasis C00000575
C00000576
D010787 Photosensitivity Disorders C00002450
C00000575
D006261 Headache C00000576
D008545 Melanoma C00002743
D009203 Myocardial Infarction C00002743
D000647 Amnesia C00002450
D050197 Atherosclerosis C00002743
D007249 Inflammation C00002743
D006505 Hepatitis C00000575
D002252 Carbon Tetrachloride Poisoning C00002743
D015746 Abdominal Pain C00000576
D004485 Eczema C00000576
D008106 Liver Cirrhosis, Experimental C00002743
D007674 Kidney Diseases C00000576
D017114 Liver Failure, Acute C00000576
D008175 Lung Neoplasms C00000576
D016410 Lymphoma, T-Cell, Cutaneous C00000576
D008881 Migraine Disorders C00000576
D009182 Mycosis Fungoides C00000576
D009325 Nausea C00000576
D000857 Olfaction Disorders C00000576
D011693 Purpura C00000576
D007319 Sleep Initiation and Maintenance Disorders C00000576
D014006 Tinea Capitis C00000576
D015837 Vestibular Diseases C00000576
D014820 Vitiligo C00000576