Species

KNApSAcK Entry

Organism name Petroselinum spp.
Genus Petroselinum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Petroselinum
Linked NCBI taxonomy ID 4042
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000575 External link 512 Bergaptan
CHEMBL24171
C022909
22 / 22 / 17 0 / 3 No. 1282 No. 25
C00002656 External link 512 Hydroquinone
/ 1,4-Benzenediol
CHEMBL537
C031927
55 / 48 / 51 156 / 14 No. 1590 No. 82

Human Protein / Gene in interactions

70 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00000575 C00002656 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000575 C00002656 0 / 0
P10275 Androgen receptor NR3C4 C00000575 C00002656 3 / 4
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000575 C00002656 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000575 C00002656 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000575 C00002656 3 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000575 C00002656 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002656 0 / 0
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00000575 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002656 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002656 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002656 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002656 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002656 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000575 1 / 0
P17658 Potassium voltage-gated channel subfamily A member 6 K C00000575 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002656 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000575 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00002656 3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002656 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002656 1 / 2
P08183 Multidrug resistance protein 1 drug C00000575 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000575 0 / 1
P54132 Bloom syndrome protein Enzyme C00002656 1 / 2
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00002656 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002656 0 / 0
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00000575 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002656 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000575 1 / 0
P68871 Hemoglobin subunit beta Secreted protein C00002656 4 / 4
O43570 Carbonic anhydrase 12 Lyase C00002656 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000575 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002656 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002656 0 / 0
O75496 Geminin Unclassified protein C00002656 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002656 0 / 0
P10145 Interleukin-8 Secreted protein C00002656 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002656 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000575 7 / 3
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002656 2 / 0
P04150 Glucocorticoid receptor NR3C1 C00002656 0 / 1
Q96RI1 Bile acid receptor NR1H4 C00002656 0 / 0
P56817 Beta-secretase 1 A1A C00000575 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002656 0 / 1
Q99700 Ataxin-2 Unclassified protein C00002656 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002656 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00002656 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00002656 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002656 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002656 0 / 0
P03372 Estrogen receptor NR3A1 C00002656 1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002656 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002656 0 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000575 1 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002656 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002656 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00002656 0 / 0
P48547 Potassium voltage-gated channel subfamily C member 1 K C00000575 0 / 0
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000575 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00002656 0 / 0
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA, Kv1.x (Shaker) C00000575 1 / 1
P35869 Aryl hydrocarbon receptor Transcription Factor C00002656 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00002656 1 / 1
P42345 Serine/threonine-protein kinase mTOR Enzyme C00002656 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002656 0 / 0
P40225 Thrombopoietin Unclassified protein C00002656 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002656 0 / 0
O00255 Menin Unclassified protein C00002656 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002656 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002656 0 / 0

156 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
64782 AEN, ISG20L1, pp12744 apoptosis enhancing nuclease C00002656
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00002656
396 ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha C00002656
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00002656
572 BAD, BBC2, BCL2L8 BCL2-associated agonist of cell death C00002656
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00002656
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00002656
664 BNIP3, NIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 C00002656
79866 BORA, C13orf34 bora, aurora kinase A activator C00002656
7832 BTG2, PC3, TIS21 BTG family, member 2 C00002656
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002656
839 CASP6, MCH2 caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) C00002656
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00002656
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002656
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002656
847 CAT catalase (EC:1.11.1.6) C00002656
6356 CCL11, SCYA11 chemokine (C-C motif) ligand 11 C00002656
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002656
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00002656
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00002656
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00002656
9134 CCNE2, CYCE2 cyclin E2 C00002656
899 CCNF, FBX1, FBXO1 cyclin F C00002656
942 CD86, B7-2, B7.2, B70, CD28LG2, LAB72 CD86 molecule C00002656
157313 CDCA2, Repo-Man cell division cycle associated 2 C00002656
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002656
1058 CENPA, CENP-A, CenH3 centromere protein A C00002656
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002656
1282 COL4A1, HANAC, ICH, POREN1, arresten collagen, type IV, alpha 1 C00002656
1436 CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R colony stimulating factor 1 receptor (EC:2.7.10.1) C00002656
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00002656
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00002656
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002656
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002656
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002656
24300 C00002656
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00002656
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00002656
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002656
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00002656
3491 CYR61, CCN1, GIG1, IGFBP10 cysteine-rich, angiogenic inducer, 61 C00002656
1611 DAP death-associated protein C00002656
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00002656
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00002656
22943 DKK1, DKK-1, SK dickkopf WNT signaling pathway inhibitor 1 C00002656
3301 DNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2 DnaJ (Hsp40) homolog, subfamily A, member 1 C00002656
3337 DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 DnaJ (Hsp40) homolog, subfamily B, member 1 C00002656
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00002656
1788 DNMT3A, DNMT3A2, M.HsaIIIA DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37) C00002656
1789 DNMT3B, ICF, ICF1, M.HsaIIIB DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) C00002656
1999 ELF3, EPR-1, ERT, ESE-1, ESX E74-like factor 3 (ets domain transcription factor, epithelial-specific ) C00002656
8772 FADD, MORT1 Fas (TNFRSF6)-associated via death domain C00002656
81610 FAM83D, C20orf129, CHICA, dJ616B8.3 family with sequence similarity 83, member D C00002656
26271 FBXO5, EMI1, FBX5, Fbxo31 F-box protein 5 C00002656
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00002656
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00002656
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00002656
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00002656
2623 GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT GATA binding protein 1 (globin transcription factor 1) C00002656
2624 GATA2, DCML, MONOMAC, NFE1B GATA binding protein 2 C00002656
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00002656
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00002656
2937 GSS, GSHS glutathione synthetase (EC:6.3.2.3) C00002656
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00002656
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00002656
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00002656
3043 HBB, CD113t-C, beta-globin hemoglobin, beta C00002656
3009 HIST1H1B, H1, H1.5, H1B, H1F5, H1s-3 histone cluster 1, H1b C00002656
3007 HIST1H1D, H1.3, H1D, H1F3, H1s-2 histone cluster 1, H1d C00002656
3008 HIST1H1E, H1.4, H1E, H1F4, H1s-4, dJ221C16.5 histone cluster 1, H1e C00002656
85235 HIST1H2AH, H2A/S, H2AFALii, H2AH, dJ86C11.1 histone cluster 1, H2ah C00002656
8329 HIST1H2AI, H2A/c, H2AFC histone cluster 1, H2ai C00002656
8331 HIST1H2AJ, H2A/E, H2AFE, dJ160A22.4 histone cluster 1, H2aj C00002656
8358 HIST1H3B, H3/l, H3FL histone cluster 1, H3b C00002656
8352 HIST1H3C, H3.1, H3/c, H3FC histone cluster 1, H3c C00002656
8359 HIST1H4A, H4FA histone cluster 1, H4a C00002656
8366 HIST1H4B, H4/I, H4FI histone cluster 1, H4b C00002656
8364 HIST1H4C, H4/g, H4FG, dJ221C16.1 histone cluster 1, H4c C00002656
8367 HIST1H4E, H4/j, H4FJ histone cluster 1, H4e C00002656
8361 HIST1H4F, H4, H4/c, H4FC histone cluster 1, H4f C00002656
8365 HIST1H4H, H4/h, H4FH histone cluster 1, H4h C00002656
8362 HIST1H4K, H4/d, H4F2iii, H4FD, dJ160A22.1 histone cluster 1, H4k C00002656
8337 HIST2H2AA3, H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA histone cluster 2, H2aa3 C00002656
317772 HIST2H2AB, H2AB histone cluster 2, H2ab C00002656
8338 HIST2H2AC, H2A, H2A-GL101, H2A/q, H2AFQ histone cluster 2, H2ac C00002656
8370 HIST2H4A, FO108, H4, H4/n, H4F2, H4FN, HIST2H4 histone cluster 2, H4a C00002656
55355 HJURP, FAKTS, URLC9, hFLEG1 Holliday junction recognition protein C00002656
3145 HMBS, PBG-D, PBGD, PORC, UPS hydroxymethylbilane synthase (EC:2.5.1.61) C00002656
3148 HMGB2, HMG2 high mobility group box 2 C00002656
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00002656
3306 HSPA2, HSP70-2, HSP70-3 heat shock 70kDa protein 2 C00002656
219844 HYLS1, HLS hydrolethalus syndrome 1 C00002656
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00002656
3558 IL2, IL-2, TCGF, lymphokine interleukin 2 C00002656
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002656
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002656
3688 ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) C00002656
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00002656
182 JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 jagged 1 C00002656
81930 KIF18A, MS-KIF18A kinesin family member 18A C00002656
4254 KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7 KIT ligand C00002656
3910 LAMA4, CMD1JJ, LAMA3, LAMA4*-1 laminin, alpha 4 C00002656
11061 LECT1, BRICD3, CHM-I, CHM1, MYETS1 leukocyte cell derived chemotaxin 1 C00002656
4000 LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 lamin A/C C00002656
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002656
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002656
8932 MBD2, DMTase, NY-CO-41 methyl-CpG binding domain protein 2 C00002656
4257 MGST1, GST12, MGST, MGST-I microsomal glutathione S-transferase 1 (EC:2.5.1.18) C00002656
4323 MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP_1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) C00002656
4324 MMP15, MT2-MMP, MTMMP2, SMCP-2 matrix metallopeptidase 15 (membrane-inserted) (EC:3.4.24.-) C00002656
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002656
4314 MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) C00002656
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002656
4352 MPL, C-MPL, CD110, MPLV, THCYT2, TPOR myeloproliferative leukemia virus oncogene C00002656
4353 MPO myeloperoxidase (EC:1.11.2.2) C00002656
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00002656
4778 NFE2, NF-E2, p45 nuclear factor, erythroid 2 C00002656
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00002656
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00002656
5036 PA2G4, EBP1, HG4-1, p38-2G4 proliferation-associated 2G4, 38kDa C00002656
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002656
25796 PGLS, 6PGL 6-phosphogluconolactonase (EC:3.1.1.31) C00002656
5429 POLH, RAD30, RAD30A, XP-V, XPV polymerase (DNA directed), eta (EC:2.7.7.7) C00002656
8493 PPM1D, PP2C-DELTA, WIP1 protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) C00002656
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00002656
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00002656
84722 PSRC1, DDA3, FP3214 proline/serine-rich coiled-coil 1 C00002656
9401 RECQL4, RECQ4 RecQ protein-like 4 (EC:3.6.4.12) C00002656
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002656
860 RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA runt-related transcription factor 2 C00002656
27244 SESN1, PA26, SEST1 sestrin 1 C00002656
83667 SESN2, HI95, SES2, SEST2 sestrin 2 C00002656
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00002656
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002656
6688 SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A spleen focus forming virus (SFFV) proviral integration oncogene C00002656
8614 STC2, STC-2, STCRP stanniocalcin 2 C00002656
7037 TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90 transferrin receptor C00002656
7077 TIMP2, CSC-21K, DDC8 TIMP metallopeptidase inhibitor 2 C00002656
25976 TIPARP, ARTD14, PARP7, pART14 TCDD-inducible poly(ADP-ribose) polymerase (EC:2.4.2.30) C00002656
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002656
8795 TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 tumor necrosis factor receptor superfamily, member 10b C00002656
8793 TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain C00002656
8718 TNFRSF25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR tumor necrosis factor receptor superfamily, member 25 C00002656
3604 TNFRSF9, 4-1BB, CD137, CDw137, ILA tumor necrosis factor receptor superfamily, member 9 C00002656
8742 TNFSF12, APO3L, DR3LG, TWEAK tumor necrosis factor (ligand) superfamily, member 12 C00002656
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00002656
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002656
94241 TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1 tumor protein p53 inducible nuclear protein 1 C00002656
8717 TRADD, Hs.89862 TNFRSF1A-associated via death domain C00002656
9618 TRAF4, CART1, MLN62, RNF83 TNF receptor-associated factor 4 C00002656
286827 TRIM59, MRF1, RNF104, TRIM57, TSBF1 tripartite motif containing 59 C00002656
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00002656
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002656
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00002656
7474 WNT5A, hWNT5A wingless-type MMTV integration site family, member 5A C00002656
7486 WRN, RECQ3, RECQL2, RECQL3 Werner syndrome, RecQ helicase-like (EC:3.6.4.12) C00002656

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (64)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#612240 Atrial fibrillation, familial, 7; atfb7 P22460
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#160120 Episodic ataxia, type 1; ea1 Q09470
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#603903 Sickle cell anemia P68871
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (60)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00731 Atrial fibrillation P22460 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00020 Colorectal cancer P68871 (marker)
H00022 Bladder cancer P68871 (marker)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00749 Episodic ataxias Q09470 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

17 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006505 Hepatitis C00000575
D010787 Photosensitivity Disorders C00000575
D011565 Psoriasis C00000575
D001855 Bone Marrow Diseases C00002656
D002869 Chromosome Aberrations C00002656
D019457 Chromosome Breakage C00002656
D056486 Drug-Induced Liver Injury C00002656
D004487 Edema C00002656
D007674 Kidney Diseases C00002656
D007680 Kidney Neoplasms C00002656
D008548 Melanosis C00002656
D048629 Micronuclei, Chromosome-Defective C00002656
D009784 Occupational Diseases C00002656
D011041 Poisoning C00002656
D011123 Polyploidy C00002656
D012140 Respiratory Tract Diseases C00002656
D012772 Shock, Septic C00002656