Organism name | Angelica spp. |
---|---|
Genus | Angelica |
Family | Apiaceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Angelica |
---|---|
Linked NCBI taxonomy ID | 40948 |
Linked level | genus |
Family in NCBI taxonomy | Apiaceae |
---|---|
ID | 4037 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | asterids |
---|---|
ID | 71274 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00002477 |
Imperatorin
|
CHEMBL453805
|
C031534
|
18 / 7 / 6 | 1 / 1 | No. 606 | No. 25 | |
C00000583 |
Isopimpinellin
|
CHEMBL140796
|
C015304
|
9 / 3 / 4 | 2 / 0 | No. 606 | No. 25 | |
C00000575 |
Bergaptan
|
CHEMBL24171
|
C022909
|
22 / 22 / 17 | 0 / 3 | No. 1282 | No. 25 | |
C00010872 |
beta-Phellandrene
/ (+/-)-beta-Phellandrene |
CHEMBL444254
|
C058582
|
No. 1898 | No. 35 |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000575 C00000583 C00002477 | 0 / 1 |
P56817 | Beta-secretase 1 | A1A | C00000575 C00000583 C00002477 | 0 / 0 |
Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000583 C00002477 | 1 / 1 |
P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000583 C00002477 | 0 / 0 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000575 C00000583 | 0 / 0 |
B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000575 C00000583 | 0 / 0 |
P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000575 C00002477 | 0 / 0 |
P00352 | Retinal dehydrogenase 1 | Enzyme | C00000575 C00002477 | 0 / 0 |
P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002477 | 0 / 0 |
P16473 | Thyrotropin receptor | Glycohormone receptor | C00000575 | 3 / 2 |
P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002477 | 0 / 0 |
P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00002477 | 0 / 0 |
P08183 | Multidrug resistance protein 1 | drug | C00000575 | 1 / 0 |
P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000575 | 0 / 1 |
P11473 | Vitamin D3 receptor | NR1I1 | C00002477 | 2 / 3 |
P16389 | Potassium voltage-gated channel subfamily A member 2 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000575 | 1 / 0 |
P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000575 | 0 / 0 |
Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000583 | 0 / 0 |
P17658 | Potassium voltage-gated channel subfamily A member 6 | K | C00000575 | 0 / 0 |
P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000575 | 7 / 3 |
P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002477 | 1 / 1 |
O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002477 | 0 / 0 |
P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00002477 | 0 / 0 |
P22001 | Potassium voltage-gated channel subfamily A member 3 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000575 | 3 / 3 |
P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000583 | 2 / 2 |
P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000575 | 1 / 1 |
P06746 | DNA polymerase beta | Enzyme | C00000583 | 0 / 0 |
O75164 | Lysine-specific demethylase 4A | Enzyme | C00002477 | 0 / 0 |
P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002477 | 2 / 0 |
P48547 | Potassium voltage-gated channel subfamily C member 1 | K | C00000575 | 0 / 0 |
P10275 | Androgen receptor | NR3C4 | C00000575 | 3 / 4 |
P22460 | Potassium voltage-gated channel subfamily A member 5 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
Q09470 | Potassium voltage-gated channel subfamily A member 1 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
O00167 | Eyes absent homolog 2 | Enzyme | C00002477 | 0 / 0 |
Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002477 | 0 / 0 |
O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002477 | 1 / 0 |
P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000575 | 1 / 0 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000583
C00002477
|
8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000583
|
OMIM | preferred title | UniProt |
---|---|---|
#300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
#219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
#612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
#300068 | Androgen insensitivity syndrome; ais |
P10275
|
#312300 | Androgen insensitivity, partial; pais |
P10275
|
#612240 | Atrial fibrillation, familial, 7; atfb7 |
P22460
|
#119900 | Digital clubbing, isolated congenital |
P15428
|
#609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
#608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
#614546 | Efavirenz, poor metabolism of |
P20813
|
#160120 | Episodic ataxia, type 1; ea1 |
Q09470
|
#137800 | Glioma susceptibility 1; glm1 |
O75874
|
#232300 | Glycogen storage disease ii |
P10253
|
#603373 | Hyperthyroidism, familial gestational |
P16473
|
#609152 | Hyperthyroidism, nonautoimmune |
P16473
|
#259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
#275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
#612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
#174800 | Mccune-albright syndrome; mas |
P63092
|
#300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
#300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
#607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
#166350 | Osseous heteroplasia, progressive; poh |
P63092
|
#102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
#103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
#603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
#612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
#604906 | Schizophrenia 9; sczd9 |
P49798
|
#181500 | Schizophrenia; sczd |
P49798
|
#313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
#277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG | name | UniProt |
---|---|---|
H00036 | Osteosarcoma |
P08684
(marker)
|
H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
H00024 | Prostate cancer |
P10275
(related)
|
H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
H00342 | Tuberculosis |
P11473
(related)
|
H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
H01205 | Coumarin resistance |
P11712
(related)
|
H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
H01269 | Congenital hyperthyroidism |
P16473
(related)
|
H00731 | Atrial fibrillation |
P22460
(related)
|
H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
H00749 | Episodic ataxias |
Q09470
(related)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|