Angelica keiskei
Species
KNApSAcK Entry
| Organism name | Angelica keiskei |
|---|---|
| Genus | Angelica |
| Family | Apiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Angelica keiskei |
|---|---|
| Linked NCBI taxonomy ID | 357850 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00008274
|
Sophoraflavanone A
/ 8-Geranylnaringenin |
CHEMBL490697
|
1 / 2 / 0 | No. 19 | No. 14 |
|
||
|
C00008197
|
Isobavachin
|
CHEMBL491534
|
C468753
|
2 / 0 | No. 28 | No. 14 |
|
|
|
C00002381
|
Corylifolinin
/ Isobavachalcone / 2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)chalcone |
CHEMBL253467
|
C468754
|
8 / 22 / 21 | No. 133 | No. 13 |
|
|
|
C00014461
|
Xanthoangelol G
/ 3'-(3,7-Dimethyl-6-hydroxyocta-2,7-dienyl)-4,2'-dihydroxy-4'-methoxychalcone |
CHEMBL1823414
|
No. 133 | No. 13 |
|
|||
|
C00007064
|
4-Hydroxyderricin
|
CHEMBL458094
|
C068243
|
17 / 27 / 26 | No. 133 | No. 13 |
|
|
|
C00040675
|
Xanthokeismin A
|
CHEMBL503569
|
No. 133 | No. 13 |
|
|||
|
C00007066
|
Xanthoangelol E
|
CHEMBL1718454
|
10 / 21 / 44 | No. 133 | No. 13 |
|
||
|
C00014460
|
Xanthoangelol F
/ 3'-Geranyl-2',4-dihydroxy-4'-methoxychalcone |
CHEMBL1722838
|
8 / 6 / 6 | No. 133 | No. 13 |
|
||
|
C00007125
|
Xanthoangelol B
|
CHEMBL494082
|
13 / 11 / 5 | No. 133 | No. 13 |
|
||
|
C00007159
|
Xanthoangelol C
|
No. 133 | No. 13 |
|
||||
|
C00007065
|
Xanthoangelol D
|
CHEMBL1711961
|
6 / 15 / 41 | No. 133 | No. 13 |
|
||
|
C00041964
|
Xanthoangelol J
|
CHEMBL491512
|
No. 133 | No. 13 |
|
|||
|
C00007124
|
Xanthoangelol
|
CHEMBL494083
CHEMBL457210 |
C068244
|
20 / 30 / 25 | 1 / 0 | No. 190 | No. 13 |
|
|
C00002451
|
Archangelicin
|
CHEMBL1426896
|
17 / 18 / 10 | No. 224 | No. 25 |
|
||
|
C00014468
|
Xanthoangelol H
/ 6'',6''-Dimethyl-5''-hydroxy-4'',5''-dihydropyrano[2'',3'':2',3']-4'-hydroxy-4'-methoxychalcone |
CHEMBL1733408
|
5 / 0 / 0 | No. 337 |
|
|||
|
C00000583
|
Isopimpinellin
|
CHEMBL140796
|
C015304
|
9 / 3 / 4 | 2 / 0 | No. 606 | No. 25 |
|
|
C00000576
|
Xanthotoxin
|
CHEMBL416
|
D008730
|
104 / 55 / 45 | 22 / 18 | No. 1282 | No. 25 |
|
|
C00030900
|
Osthenol
|
CHEMBL350475
|
C114745
|
2 / 0 / 0 | No. 2087 |
|
||
|
C00041229
|
(9Z,11S,16R)-Dihydroxyoctadeca-9,17-dien-12,14-diyn-1-yl acetate
|
CHEMBL511705
CHEMBL490698 CHEMBL2204415 |
1 / 0 / 0 | No. 2971 |
|
|||
|
C00041963
|
Xanthoangelol I
/ (+)-Xanthoangelol I |
No. 3649 |
|
|||||
|
C00040677
|
Xanthokeismin C
/ (+)-Xanthokeismin C |
CHEMBL481120
|
No. 5000 |
|
||||
|
C00040676
|
Xanthokeismin B
/ (+)-Xanthokeismin B |
CHEMBL482098
|
No. 5000 |
|
||||
|
C00041493
|
Deoxydihydroxanthoangelol H
|
CHEMBL453501
|
No. 6203 |
|
Human Protein / Gene in interactions
149 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00007064 C00007065 C00007066 C00007124 C00007125 C00014460 C00014468 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000576 C00002451 C00007064 C00007065 C00007124 C00007125 C00014460 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002451 C00007064 C00007065 C00007066 C00007124 C00007125 C00014468 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002451 C00007064 C00007066 C00007124 C00007125 C00014460 | 1 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000576 C00000583 C00007064 C00007065 C00007124 C00007125 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002451 C00007064 C00007066 C00007124 C00007125 C00014460 | 2 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002451 C00007064 C00007066 C00007124 C00014460 | 1 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000576 C00002451 C00007065 C00007066 C00007125 | 7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000576 C00002451 C00007064 C00014468 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000583 C00002451 C00007066 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002451 C00007125 C00014468 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002451 C00007064 C00007124 | 4 / 3 |
| P56817 | Beta-secretase 1 | A1A | C00000576 C00000583 C00030900 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00007064 C00014460 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000583 C00007124 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000576 C00002451 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000583 C00002451 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000576 C00000583 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000583 C00002451 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000583 C00002451 | 2 / 2 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00007064 C00007124 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00007064 C00007124 | 2 / 5 |
| P02545 | Prelamin-A/C | Unclassified protein | C00007064 C00007124 | 11 / 10 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00007064 C00007124 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00007064 C00007124 | 4 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00007064 C00007124 | 1 / 2 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00007065 C00007066 | 7 / 37 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00007064 C00014460 | 0 / 3 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00007066 C00014460 | 2 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002451 C00007124 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000576 C00002451 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000576 C00030900 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000576 C00002381 | 1 / 8 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000576 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000576 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000576 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00041229 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000576 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000576 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000576 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000576 | 0 / 1 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00000576 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00007124 | 1 / 0 |
| Q9BQF6 | Sentrin-specific protease 7 | Enzyme | C00007125 | 0 / 0 |
| Q9GZR1 | Sentrin-specific protease 6 | Enzyme | C00007125 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000576 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000576 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000576 | 2 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000576 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000576 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000576 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000576 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000576 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000576 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000576 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000576 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000576 | 1 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000576 | 1 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000576 | 0 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000576 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00007124 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000583 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002451 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000576 | 1 / 2 |
| P42574 | Caspase-3 | C14 | C00007125 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000576 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000576 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000576 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000576 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000576 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000576 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000576 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000576 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000576 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000576 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000576 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000576 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000576 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000576 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000576 | 3 / 2 |
| P03956 | Interstitial collagenase | M10A | C00000576 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000576 | 0 / 0 |
| Q96LD8 | Sentrin-specific protease 8 | Enzyme | C00007125 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00007066 | 1 / 1 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000576 | 1 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00000576 | 1 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000576 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000576 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000576 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00002381 | 2 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000576 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000576 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000576 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000576 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000576 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002381 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000576 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000576 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000576 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00007124 | 1 / 1 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00002381 | 1 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00002381 | 2 / 3 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000576 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000576 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000576 | 2 / 1 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000576 | 2 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000576 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00008274 | 2 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000576 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000576 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000576 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000576 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000576 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000576 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000576 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000576 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000576 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000576 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000576 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000576 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000576 | 0 / 0 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00002381 | 4 / 5 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000576 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000576 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00000576 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000576 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00007124 | 1 / 1 |
| P21802 | Fibroblast growth factor receptor 2 | TK tyrosine-protein kinase TLK subfamily | C00002381 | 9 / 3 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000576 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000576 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00000576 | 2 / 1 |
| P10275 | Androgen receptor | NR3C4 | C00000576 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000576 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000576 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000576 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000576 | 0 / 0 |
| P10721 | Mast/stem cell growth factor receptor Kit | Pdgfr | C00002381 | 4 / 3 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000576 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000576 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000576 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000576 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000576 | 0 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000576 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000576 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00000576 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00007125 | 0 / 0 |
| Q09470 | Potassium voltage-gated channel subfamily A member 1 | KCNA, Kv1.x (Shaker) | C00000576 | 1 / 1 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00014468 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000576 | 1 / 0 |
25 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000576
C00000583
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000576
C00007124
|
| 8824 | CES2, CE-2, CES2A1, PCE-2, iCE | carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) |
C00000576
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00008197
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00008197
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000576
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000576
|
| 8553 | BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 | basic helix-loop-helix family, member e40 |
C00000576
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00000576
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000576
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000576
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00000576
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000583
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000576
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000576
|
| 1553 | CYP2A13, CPAD, CYP2A, CYPIIA13 | cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) |
C00000576
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00000576
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000576
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00000576
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000576
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00000576
|
| 3355109 |
C00000576
|
||
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00000576
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000576
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000576
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (118)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #207410 | Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 |
P21802
|
| #101200 | Apert syndrome |
P21802
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #123790 | Beare-stevenson cutis gyrata syndrome; bstvs |
P21802
|
| #614592 | Bent bone dysplasia syndrome; bbds |
P21802
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #123500 | Crouzon syndrome |
P21802
|
| #162800 | Cyclic neutropenia |
P08246
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #160120 | Episodic ataxia, type 1; ea1 |
Q09470
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #606764 | Gastrointestinal stromal tumor; gist |
P10721
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #602089 | Hemangioma, capillary infantile |
P35968
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #123150 | Jackson-weiss syndrome; jws |
P21802
|
| #149730 | Lacrimoauriculodentodigital syndrome; ladd |
P21802
|
| #601626 | Leukemia, acute myeloid; aml |
P10721
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #101600 | Pfeiffer syndrome |
P11362
P21802 |
| #172700 | Pick disease of brain |
P10636
|
| #172800 | Piebald trait; pbt |
P10721
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609579 | Scaphocephaly, maxillary retrusion, and mental retardation |
P21802
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
P10721
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (109)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) P08581 (related) P21802 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P08581 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P10721
(related)
P10721 (marker) |
| H00170 | Piebaldism |
P10721
(related)
|
| H00023 | Testicular cancer |
P10721
(marker)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
P21802 (related) |
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00642 | Lacrimo-auriculo-dento-digital syndrome (LADD) |
P21802
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00749 | Episodic ataxias |
Q09470
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
18 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D015746 | Abdominal Pain |
C00000576
|
| D056486 | Drug-Induced Liver Injury |
C00000576
|
| D004485 | Eczema |
C00000576
|
| D006261 | Headache |
C00000576
|
| D007674 | Kidney Diseases |
C00000576
|
| D017114 | Liver Failure, Acute |
C00000576
|
| D008175 | Lung Neoplasms |
C00000576
|
| D016410 | Lymphoma, T-Cell, Cutaneous |
C00000576
|
| D008881 | Migraine Disorders |
C00000576
|
| D009182 | Mycosis Fungoides |
C00000576
|
| D009325 | Nausea |
C00000576
|
| D000857 | Olfaction Disorders |
C00000576
|
| D011565 | Psoriasis |
C00000576
|
| D011693 | Purpura |
C00000576
|
| D007319 | Sleep Initiation and Maintenance Disorders |
C00000576
|
| D014006 | Tinea Capitis |
C00000576
|
| D015837 | Vestibular Diseases |
C00000576
|
| D014820 | Vitiligo |
C00000576
|