Species

KNApSAcK Entry

Organism name Heracleum lanatum
Genus Heracleum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Heracleum maximum
Linked NCBI taxonomy ID 40918
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000576 External link 512 Xanthotoxin
CHEMBL416
D008730
104 / 55 / 45 22 / 18 No. 1282 No. 25

Human Protein / Gene in interactions

104 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000576 1 / 0
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000576 1 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000576 1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000576 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000576 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000576 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000576 2 / 2
P08246 Neutrophil elastase S1A C00000576 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00000576 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000576 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000576 0 / 0
P29466 Caspase-1 C14 C00000576 0 / 0
P17252 Protein kinase C alpha type Alpha C00000576 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000576 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000576 2 / 2
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000576 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000576 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00000576 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000576 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000576 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000576 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000576 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000576 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000576 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000576 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000576 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000576 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000576 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000576 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000576 0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 C00000576 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000576 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00000576 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00000576 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000576 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000576 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000576 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000576 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000576 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000576 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000576 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000576 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000576 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000576 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000576 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000576 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000576 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000576 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000576 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000576 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000576 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000576 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000576 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000576 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000576 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000576 0 / 0
P08311 Cathepsin G S1A C00000576 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000576 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000576 0 / 0
P03956 Interstitial collagenase M10A C00000576 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000576 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000576 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000576 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000576 1 / 0
P04150 Glucocorticoid receptor NR3C1 C00000576 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000576 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000576 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000576 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000576 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000576 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000576 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000576 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000576 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000576 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000576 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000576 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000576 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000576 2 / 1
P56817 Beta-secretase 1 A1A C00000576 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000576 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000576 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000576 0 / 0
P03372 Estrogen receptor NR3A1 C00000576 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000576 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000576 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000576 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000576 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000576 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000576 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000576 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000576 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000576 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000576 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000576 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000576 0 / 0
P10275 Androgen receptor NR3C4 C00000576 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000576 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000576 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000576 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000576 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000576 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000576 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000576 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000576 1 / 1

22 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00000576
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000576
8553 BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 basic helix-loop-helix family, member e40 C00000576
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00000576
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000576
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000576
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000576
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000576
8824 CES2, CE-2, CES2A1, PCE-2, iCE carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) C00000576
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000576
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000576
1553 CYP2A13, CPAD, CYP2A, CYPIIA13 cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) C00000576
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00000576
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000576
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00000576
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000576
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00000576
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000576
3355109 C00000576
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000576
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000576
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000576

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (55)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#160120 Episodic ataxia, type 1; ea1 Q09470
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (45)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00749 Episodic ataxias Q09470 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

18 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D015746 Abdominal Pain C00000576
D056486 Drug-Induced Liver Injury C00000576
D004485 Eczema C00000576
D006261 Headache C00000576
D007674 Kidney Diseases C00000576
D017114 Liver Failure, Acute C00000576
D008175 Lung Neoplasms C00000576
D016410 Lymphoma, T-Cell, Cutaneous C00000576
D008881 Migraine Disorders C00000576
D009182 Mycosis Fungoides C00000576
D009325 Nausea C00000576
D000857 Olfaction Disorders C00000576
D011565 Psoriasis C00000576
D011693 Purpura C00000576
D007319 Sleep Initiation and Maintenance Disorders C00000576
D014006 Tinea Capitis C00000576
D015837 Vestibular Diseases C00000576
D014820 Vitiligo C00000576