Species

KNApSAcK Entry

Organism name Wasabia japonica
Genus Wasabia
Family Brassicaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Eutrema wasabi
Linked NCBI taxonomy ID 75806
Linked level species

Family

Family in NCBI taxonomy Brassicaceae
ID 3700

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (21)

Species Activity
Wasabia japonica (Miq.) Matsum. Antiaggregant
Wasabia japonica (Miq.) Matsum. Anticancer
Wasabia japonica (Miq.) Matsum. Asthma
Wasabia japonica (Miq.) Matsum. Bacteria
Wasabia japonica (Miq.) Matsum. Cancer
Wasabia japonica (Miq.) Matsum. Cancer, lung
Wasabia japonica (Miq.) Matsum. Cancer, prostate
Wasabia japonica (Miq.) Matsum. Caries
Wasabia japonica (Miq.) Matsum. Congestion
Wasabia japonica (Miq.) Matsum. Decongestant
Wasabia japonica (Miq.) Matsum. Diaphoretic
Wasabia japonica (Miq.) Matsum. Fungus
Wasabia japonica (Miq.) Matsum. High Blood Pressure
Wasabia japonica (Miq.) Matsum. Infection
Wasabia japonica (Miq.) Matsum. Mycosis
Wasabia japonica (Miq.) Matsum. Parasite
Wasabia japonica (Miq.) Matsum. Sinusosis
Wasabia japonica (Miq.) Matsum. Streptococcus
Wasabia japonica (Miq.) Matsum. Thrombosis
Wasabia japonica (Miq.) Matsum. Trypanosomiasis
Wasabia japonica (Miq.) Matsum. Virus

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000580 External link 512 trans-p-Coumaric acid
/ trans-p-Hydroxycinnamic acid
CHEMBL66879
CHEMBL2336752
23 / 13 / 18 No. 904 No. 6
C00034327 External link 512 (E)-Sinapic acid
/ trans-Sinapic acid
/ 4-Hydroxy-3,5-dimethoxy-(E)-cinnamic acid
CHEMBL109341
5 / 5 / 5 No. 1366 No. 6
C00034325 External link 512 E-Ferulic acid
/ (E)-Ferulic acid
/ trans-Ferulic acid
/ 4-Hydroxy-3-methoxy-(E)-cinnamic acid
CHEMBL32749
110 / 52 / 40 No. 1366 No. 6
C00033558 External link 512 E)-3,4-Dimethoxycinnamic acid
/ 3,4-Dimethoxy-trans-cinnamic acid
CHEMBL320295
10 / 11 / 12 No. 1366 No. 6
C00034328 External link 512 Sinapic acid methyl ester
/ trans-Sinapic acid methyl ester
CHEMBL146713
No. 2905 No. 6
C00026890 External link 512 Wasalexin A
CHEMBL103746
No. 5651
C00026891 External link 512 Wasalexin B
CHEMBL103746
No. 5651
C00026511 External link 512 1-Methoxyindole-3-carboxylate
No. 8288

Human Protein / Gene in interactions

124 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000580 C00033558 C00034325 C00034327 0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000580 C00034325 C00034327 3 / 0
P22748 Carbonic anhydrase 4 Lyase C00000580 C00034325 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00000580 C00034325 0 / 0
P03372 Estrogen receptor NR3A1 C00000580 C00034325 1 / 1
Q16790 Carbonic anhydrase 9 Lyase C00000580 C00034325 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00033558 C00034325 0 / 0
P14679 Tyrosinase Oxidoreductase C00000580 C00034325 4 / 2
P00915 Carbonic anhydrase 1 Lyase C00000580 C00034325 0 / 0
O75496 Geminin Unclassified protein C00033558 C00034325 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00033558 C00034325 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000580 C00034325 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000580 C00034325 1 / 2
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000580 C00034325 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000580 C00034325 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000580 C00034325 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000580 C00034325 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000580 C00034325 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00034325 C00034327 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000580 C00034325 1 / 8
P00918 Carbonic anhydrase 2 Lyase C00000580 C00034325 1 / 2
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000580 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00034325 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00034325 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00034325 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00034325 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00034325 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00034325 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00034325 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00034325 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00034325 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00034325 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00034325 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00034325 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00034325 0 / 1
P14780 Matrix metalloproteinase-9 M10A C00034325 2 / 2
P11473 Vitamin D3 receptor NR1I1 C00033558 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00034325 2 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00034325 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00034325 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00034325 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00034325 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00034325 0 / 0
P17252 Protein kinase C alpha type Alpha C00034325 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00034325 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00034325 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00034325 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00034325 1 / 0
P29466 Caspase-1 C14 C00034325 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00033558 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00034327 2 / 2
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00034325 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00034325 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000580 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00034325 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00034325 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00034325 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00034325 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00034325 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00034325 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00034325 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00034325 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00034325 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00034325 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00034325 0 / 0
P15121 Aldose reductase Enzyme C00000580 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00034325 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00034325 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00034325 1 / 0
P08246 Neutrophil elastase S1A C00034325 2 / 1
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00034325 0 / 0
P08311 Cathepsin G S1A C00034325 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00034325 1 / 0
P03956 Interstitial collagenase M10A C00034325 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00034325 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00034325 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00034325 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00034325 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00034325 2 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00034325 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00034325 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00034325 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00034325 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00034325 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00034325 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00034325 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00034325 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00034325 1 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00034325 1 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00034325 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00034325 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00034325 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00033558 3 / 3
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00034325 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00033558 2 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00034325 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000580 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00034325 1 / 0
P22303 Acetylcholinesterase Hydrolase C00034325 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00034325 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00034325 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00034325 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00034325 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00034325 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00034325 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00034325 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00033558 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00034325 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00034325 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00034325 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000580 1 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00034325 5 / 1
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00034325 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00034325 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00034325 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00034325 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00034325 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00033558 4 / 1
P06239 Tyrosine-protein kinase Lck Src C00034325 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00034325 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000580 1 / 0
Q12794 Hyaluronidase-1 Enzyme C00034325 1 / 2
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00034325 3 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00034327 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (66)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#600807 Asthma, susceptibility to Q13093
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (50)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)