Arctium lappa
Species
KNApSAcK Entry
| Organism name | Arctium lappa |
|---|---|
| Genus | Arctium |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Arctium lappa |
|---|---|
| Linked NCBI taxonomy ID | 4217 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (17)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000587
|
(-)-Pinoresinol
|
CHEMBL267963
CHEMBL487611 CHEMBL460862 |
7 / 5 / 6 | No. 38 | No. 21 |
|
||
|
C00003215
|
Arctiopicrin
|
No. 211 | No. 38 |
|
||||
|
C00000606
|
(-)-Matairesinol
|
CHEMBL425148
|
C068935
|
1 / 0 / 0 | No. 223 | No. 21 |
|
|
|
C00000609
|
(-)-Arctigenin
|
CHEMBL369142
CHEMBL435734 CHEMBL1966556 |
C071942
|
13 / 7 / 6 | No. 223 | No. 21 |
|
|
|
C00000604
|
(-)-Secoisolariciresinol
|
CHEMBL368347
|
C060283
|
2 / 1 / 1 | 1 / 0 | No. 282 | No. 21 |
|
|
C00000605
|
(+)-Secoisolariciresinol
|
CHEMBL368347
|
2 / 1 / 1 | No. 282 | No. 21 |
|
||
|
C00002724
|
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
|
|
C00012785
|
Arctiol
/ [2S-(2alpha,3beta,4aalpha,8abeta)]-Decahydro-3-hydroxy-alpha,alpha,4a-trimethyl-8-methylene-2-naphthalenemethanol |
No. 524 | No. 38 |
|
||||
|
C00000636
|
(+)-Pinoresinolin
|
No. 621 | No. 21 |
|
||||
|
C00000646
|
(-)-Arctiin
|
CHEMBL388452
CHEMBL1526371 |
C077992
|
4 / 15 / 11 | 0 / 2 | No. 653 | No. 22 |
|
|
C00000603
|
(-)-Lariciresinol
|
CHEMBL518421
|
C060282
|
2 / 1 / 1 | No. 700 | No. 21 |
|
|
|
C00000688
|
Lappaol C
|
No. 1420 |
|
|||||
|
C00030534
|
Isolappaol C
|
No. 1420 |
|
|||||
|
C00030637
|
Lappaol D
|
No. 1420 |
|
|||||
|
C00000687
|
Lappaol A
|
No. 1420 |
|
|||||
|
C00030123
|
Diarctigenin
/ (-)-Diarctigenin |
No. 2412 |
|
|||||
|
C00030638
|
Lappaol F
/ (+)-Lappaol F |
No. 2412 |
|
Human Protein / Gene in interactions
48 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000603 C00000604 C00000605 C00000609 C00002724 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000603 C00000604 C00000605 C00000609 C00002724 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000609 C00002724 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000609 C00002724 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00000646 C00002724 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000609 C00002724 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000587 C00002724 | 0 / 3 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002724 | 0 / 1 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002724 | 3 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000587 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000646 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002724 | 3 / 2 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000587 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002724 | 0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00000606 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000609 | 2 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00002724 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000609 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002724 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002724 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000609 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000646 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002724 | 2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000587 | 5 / 3 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000609 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000609 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002724 | 3 / 3 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000609 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000587 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000646 | 4 / 1 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00000609 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000609 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002724 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002724 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002724 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000587 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002724 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002724 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002724 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002724 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002724 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000587 | 0 / 0 |
38 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000604
|
| 47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
| 358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
| 360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
| 4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
| 114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
| 1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
| 2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
| 2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00002724
|
| 3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
| 3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
| 3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
| 8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
| 5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
| 7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
|
| 7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002724
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002724
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002724
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002724
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (44)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| %606641 | Body mass index; bmi |
P37231
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (37)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00016 | Oral cancer |
P40763
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D005921 | Glomerulonephritis |
C00000646
|
| D011230 | Precancerous Conditions |
C00000646
|
| D000647 | Amnesia |
C00002724
|
| D056486 | Drug-Induced Liver Injury |
C00002724
|
| D006937 | Hypercholesterolemia |
C00002724
|
| D006951 | Hyperlipoproteinemias |
C00002724
|
| D015228 | Hypertriglyceridemia |
C00002724
|
| D052456 | Hypoalphalipoproteinemias |
C00002724
|
| D008545 | Melanoma |
C00002724
|
| D009336 | Necrosis |
C00002724
|
| D015431 | Weight Loss |
C00002724
|