Species

KNApSAcK Entry

Organism name Kadsura angustifolia
Genus Kadsura
Family Schisandraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Kadsura angustifolia
Linked NCBI taxonomy ID 124779
Linked level species

Family

Family in NCBI taxonomy Schisandraceae
ID 16733

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (27)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00038093 External link 512 (24Z)-3-Oxo-12alpha-hydroxylanosta-8,24-dien-26-oic acid
No. 86 No. 51
C00038474 External link 512 Anwuweizic acid
CHEMBL223317
No. 86 No. 51
C00039536 External link 512 Kadsulignan L
CHEMBL464848
CHEMBL485477
CHEMBL1310734
7 / 1 / 1 No. 105 No. 21
C00030418 External link 512 Gomisin R
CHEMBL465720
CHEMBL1237139
No. 105 No. 21
C00039537 External link 512 Kadsulignan N
CHEMBL517461
No. 105 No. 21
C00029829 External link 512 Binankadsurin A
CHEMBL447240
CHEMBL518555
No. 105 No. 21
C00039511 External link 512 Kadangustin B
CHEMBL457477
No. 105 No. 21
C00040254 External link 512 Schisantherin Q
CHEMBL517629
No. 105 No. 21
C00040253 External link 512 Schisantherin P
CHEMBL517654
No. 105 No. 21
C00039510 External link 512 Kadangustin A
/ Kadsuphilin K
CHEMBL459243
No. 105 No. 21
C00038952 External link 512 Deangeloylschisantherin F
CHEMBL465892
No. 105 No. 21
C00031314 External link 512 Schisantherin F
CHEMBL465865
No. 147 No. 21
C00030582 External link 512 Kadsurarin
/ Kadsurarin II
CHEMBL464501
No. 147 No. 21
C00040252 External link 512 Schisantherin L
CHEMBL465719
No. 147 No. 21
C00039516 External link 512 Kadangustin G
CHEMBL465516
CHEMBL465863
No. 147 No. 21
C00039515 External link 512 Kadangustin F
CHEMBL465516
CHEMBL465863
No. 147 No. 21
C00039958 External link 512 Perseal F
/ (-)-Perseal F
CHEMBL459216
No. 215 No. 23
C00039514 External link 512 Kadangustin E
CHEMBL435985
No. 216 No. 21
C00039512 External link 512 Kadangustin C
CHEMBL450645
No. 216 No. 21
C00039513 External link 512 Kadangustin D
CHEMBL499278
No. 216 No. 21
C00039520 External link 512 Kadangustin K
No. 282 No. 21
C00039519 External link 512 Kadangustin J
/ (+)-Kadangustin J
No. 282 No. 21
C00039518 External link 512 Kadangustin I
/ (-)-Kadangustin I
No. 282 No. 21
C00007215 External link 512 Mesodihydroguaiaretic acid
CHEMBL430464
CHEMBL375927
CHEMBL1976696
16 / 18 / 12 No. 282 No. 21
C00030746 External link 512 meso-Dihydroguaiaretic acid
CHEMBL430464
CHEMBL375927
CHEMBL1976696
16 / 18 / 12 No. 282 No. 21
C00039517 External link 512 Kadangustin H
/ (-)-Kadangustin H
CHEMBL458390
No. 282 No. 21
C00024182 External link 512 Kadsulignan K
/ Heteroclitin G
No. 6075

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00007215 C00030746 C00039536 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00007215 C00030746 2 / 2
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00007215 C00030746 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00007215 C00030746 0 / 0
P37840 Alpha-synuclein Unclassified protein C00007215 C00030746 4 / 2
P00918 Carbonic anhydrase 2 Lyase C00007215 C00030746 1 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00007215 C00030746 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00007215 C00030746 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00007215 C00030746 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00007215 C00030746 2 / 0
Q99700 Ataxin-2 Unclassified protein C00007215 C00030746 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00007215 C00030746 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00007215 C00030746 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00007215 C00030746 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00007215 C00030746 7 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00007215 C00030746 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00039536 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00039536 0 / 0
P42858 Huntingtin Unclassified protein C00039536 1 / 1
P41145 Kappa-type opioid receptor Opioid receptor C00039536 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00039536 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00039536 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#143100 Huntington disease; hd P42858
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (13)

KEGG name UniProt
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)