Species

KNApSAcK Entry

Organism name Salvinia molesta D.S.Mitch.
Genus Salvinia
Family Salviniaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvinia
Linked NCBI taxonomy ID 32187
Linked level genus

Family

Family in NCBI taxonomy Salviniaceae
ID 32186

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Euphyllophyta
ID 78536

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00031030 External link 512 Pikuroside
/ (-)-Pikuroside
No. 287 No. 36
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6
C00003011 External link 512 Paeoniflorin
CHEMBL1078549
CHEMBL1397567
CHEMBL1972762
C015423
4 / 4 / 8 3 / 2 No. 1566
C00034054 External link 512 Methyl benzoate
CHEMBL16435
C044605
4 / 6 / 6 No. 4170

Human Protein / Gene in interactions

71 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00034054 3 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 C00003011 1 / 2
O00255 Menin Unclassified protein C00000615 C00003011 2 / 5
P03372 Estrogen receptor NR3A1 C00000615 C00003011 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00003011 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000615 1 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000615 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 2 / 2
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000615 3 / 0
P06746 DNA polymerase beta Enzyme C00000615 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000615 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000615 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000615 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 4 / 2
P14780 Matrix metalloproteinase-9 M10A C00000615 2 / 2
P02545 Prelamin-A/C Unclassified protein C00000615 11 / 10
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000615 1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00000615 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00000615 1 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000615 0 / 1
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000615 1 / 8
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000615 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000615 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000615 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000615 1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000615 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000615 0 / 0
P15121 Aldose reductase Enzyme C00000615 0 / 0
P10145 Interleukin-8 Secreted protein C00034054 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000615 0 / 0
P03956 Interstitial collagenase M10A C00000615 0 / 1
P14679 Tyrosinase Oxidoreductase C00000615 4 / 2
P06280 Alpha-galactosidase A Enzyme C00000615 1 / 1
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000615 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000615 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000615 0 / 1
P08253 72 kDa type IV collagenase M10A C00000615 1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 3 / 3
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000615 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 5 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000615 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000615 0 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000615 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000615 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00034054 0 / 0
P10275 Androgen receptor NR3C4 C00034054 3 / 4
P07451 Carbonic anhydrase 3 Lyase C00000615 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000615 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
Q9UBT6 DNA polymerase kappa Enzyme C00000615 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 1 / 1
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000615 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 0 / 0

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
664 BNIP3, NIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 C00003011
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00003011
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00003011

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (67)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#163950 Noonan syndrome 1; ns1 Q06124
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278300 Xanthinuria, type i P47989

KEGG DISEASE (67)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00003011
D007022 Hypotension C00003011