Species

KNApSAcK Entry

Organism name Kadsura interior
Genus Kadsura
Family Schisandraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Kadsura
Linked NCBI taxonomy ID 105749
Linked level genus

Family

Family in NCBI taxonomy Schisandraceae
ID 16733

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000670 External link 512 (+)-Gomisin A
CHEMBL403578
CHEMBL1159658
CHEMBL1834755
5 / 0 / 0 No. 105 No. 21
C00000712 External link 512 (-)-Gomisin J
CHEMBL251864
C082091
No. 105 No. 21
C00046205 External link 512 Neokadsuranin
CHEMBL464848
CHEMBL485477
CHEMBL1310734
7 / 1 / 1 No. 105 No. 21
C00041561 External link 512 Gomisin A
CHEMBL403578
CHEMBL1159658
CHEMBL1834755
C033585
5 / 0 / 0 2 / 2 No. 105 No. 21
C00033990 External link 512 Kadsurin
CHEMBL559796
CHEMBL1460441
C075123
4 / 3 / 1 No. 105 No. 21
C00045635 External link 512 Angeloylgomisin R
CHEMBL489960
No. 147 No. 21
C00046028 External link 512 Interiotherin B
CHEMBL490161
CHEMBL1669434
No. 147 No. 21
C00000717 External link 512 Interiotherin A
CHEMBL484669
No. 216 No. 21
C00000718 External link 512 Schisantherin D
CHEMBL475880
C082093
No. 216 No. 21
C00041562 External link 512 Gomisin G
CHEMBL515928
No. 216 No. 21
C00024179 External link 512 Heteroclitin D
CHEMBL485478
CHEMBL1444176
4 / 7 / 3 No. 1294
C00033952 External link 512 Interiorin
CHEMBL483434
No. 1294
C00046029 External link 512 Interiotherin D
/ (-)-Interiotherin D
CHEMBL489756
No. 1294
C00024181 External link 512 Heteroclitin F
CHEMBL519496
No. 1294

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00000670 C00024179 C00033990 C00041561 C00046205 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000670 C00041561 C00046205 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000670 C00041561 C00046205 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00024179 C00033990 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000670 C00041561 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00000670 C00041561 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00033990 2 / 0
P42858 Huntingtin Unclassified protein C00046205 1 / 1
P41145 Kappa-type opioid receptor Opioid receptor C00046205 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00024179 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00033990 1 / 1
P06746 DNA polymerase beta Enzyme C00024179 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00046205 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00046205 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00041561
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00041561

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#143100 Huntington disease; hd P42858
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (5)

KEGG name UniProt
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00041561
D011230 Precancerous Conditions C00041561