Species

KNApSAcK Entry

Organism name Schisandra rubriflora
Genus Schisandra
Family Schisandraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Schisandra rubriflora
Linked NCBI taxonomy ID 124791
Linked level species

Family

Family in NCBI taxonomy Schisandraceae
ID 16733

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (21)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000712 External link 512 (-)-Gomisin J
CHEMBL251864
C082091
No. 105 No. 21
C00002634 External link 512 Wuweizisu C
/ (-)-Wuweizisu C
CHEMBL437412
C031409
No. 105 No. 21
C00041803 External link 512 Rubrisandrin B
No. 105 No. 21
C00030191 External link 512 Epigomisin O
CHEMBL522973
CHEMBL521975
No. 105 No. 21
C00030417 External link 512 Gomisin O
CHEMBL522973
CHEMBL521975
No. 105 No. 21
C00041802 External link 512 Rubrisandrin A
CHEMBL1080599
CHEMBL1080600
No. 105 No. 21
C00041224 External link 512 (+)-Gomisin M2
CHEMBL518108
CHEMBL1426408
7 / 4 / 2 No. 105 No. 21
C00041495 External link 512 Schisandrin A
/ Deoxyschisandrin
CHEMBL253908
CHEMBL490126
CHEMBL479898
C034734
4 / 1 / 4 2 / 0 No. 105 No. 21
C00040177 External link 512 Rubriflorin B
No. 105 No. 21
C00041563 External link 512 Gomisin K3
/ Schisanhenol
CHEMBL490125
CHEMBL520939
C045309
7 / 10 / 8 No. 105 No. 21
C00041339 External link 512 Angeloylgomisin P
CHEMBL253687
CHEMBL253907
CHEMBL490308
CHEMBL491342
CHEMBL1867703
CHEMBL2313594
No. 147 No. 21
C00040176 External link 512 Rubriflorin A
CHEMBL488100
CHEMBL1782120
No. 147 No. 21
C00041921 External link 512 Tigloylgomisin P
CHEMBL253687
CHEMBL253907
CHEMBL490308
CHEMBL491342
CHEMBL1867703
CHEMBL2313594
No. 147 No. 21
C00039369 External link 512 Henridilactone B
No. 178 No. 38
C00007215 External link 512 Mesodihydroguaiaretic acid
CHEMBL430464
CHEMBL375927
CHEMBL1976696
16 / 18 / 12 No. 282 No. 21
C00039601 External link 512 Lancifodilactone C
/ (+)-Lancifodilactone C
No. 409
C00039602 External link 512 Lancifodilactone D
/ (+)-Lancifodilactone D
No. 409
C00039765 External link 512 Micrandilactone A
/ (+)-Micrandilactone A
No. 409
C00039368 External link 512 Henridilactone A
No. 409
C00039768 External link 512 Micrandilactone G
/ (+)-Micrandilactone G
No. 409
C00040178 External link 512 Rubriflorin C
No. 1930

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00007215 C00041224 C00041495 C00041563 0 / 0
O75496 Geminin Unclassified protein C00007215 C00041224 C00041495 C00041563 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00007215 C00041563 7 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00007215 C00041224 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00007215 C00041224 1 / 1
Q99700 Ataxin-2 Unclassified protein C00007215 C00041563 1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00041495 C00041563 1 / 4
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00007215 C00041224 2 / 0
P00918 Carbonic anhydrase 2 Lyase C00007215 1 / 2
P17405 Sphingomyelin phosphodiesterase Enzyme C00007215 2 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00041563 0 / 0
P37840 Alpha-synuclein Unclassified protein C00007215 4 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00007215 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00007215 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00007215 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00007215 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00041224 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00007215 0 / 1
P06746 DNA polymerase beta Enzyme C00041224 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00007215 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00041563 1 / 1
P33527 Multidrug resistance-associated protein 1 drugs C00041495 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00041495
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00041495

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (17)

KEGG name UniProt
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)