Species

KNApSAcK Entry

Organism name Coleogyne ramosissima Torr.
Genus Coleogyne
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Coleogyne ramosissima
Linked NCBI taxonomy ID 401069
Linked level species

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005548 External link 512 Narcissin
/ Isorhamnetin 3-O-rutinoside
CHEMBL84174
CHEMBL258394
CHEMBL1711509
CHEMBL2165403
C031062
7 / 1 / 2 No. 1 No. 15
C00005666 External link 512 Spinacetin 3-glucoside
/ Spinacetin 3-O-beta-glucopyranoside
No. 2 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
38 / 43 / 34 No. 2 No. 15
C00005715 External link 512 Limocitrin 3-glucoside
/ Limocitrin 3-O-beta-glucopyranoside
/ Limocitrin 3-O-beta-D-glucopyranoside
No. 2 No. 15
C00009075 External link 512 Procyanidin B1
/ Epicatechin-(4beta->8)-catechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479579
20 / 7 / 8 No. 16 No. 19
C00009076 External link 512 Procyanidin B5
/ Epicatechin-(4beta-6)-epicatechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00009077 External link 512 Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479580
20 / 7 / 8 10 / 0 No. 16 No. 19
C00009071 External link 512 Procyanidin B3
/ Catechin-(4alpha->8)-catechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
20 / 7 / 8 No. 16 No. 19
C00002935 External link 512 Procyanidin B4
/ Catechin-(4alpha->8)-epicatechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
20 / 7 / 8 No. 16 No. 19
C00009098 External link 512 Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin
CHEMBL290632
13 / 5 / 6 No. 29 No. 19
C00002707 External link 512 Picein
/ 4-Hydroxyacetophenone 4-glucoside
CHEMBL1512620
C050880
3 / 0 / 0 No. 45 No. 72
C00000956 External link 512 (-)-Epicatechin
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
85 / 58 / 54 No. 52 No. 14
C00000947 External link 512 D-Catechol
/ D-Catechin
/ Teafuran 30A
/ (+)-Catechin
/ Dexcyanidanol
/ (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
D002392
85 / 58 / 54 91 / 13 No. 52 No. 14
C00000723 External link 512 Liriodendrin
/ Acanthoside D
/ (+)-Syringaresinol di-O-beta-glucopyranoside
CHEMBL446836
CHEMBL505393
2 / 2 / 2 No. 152

Human Protein / Gene in interactions

112 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P05129 Protein kinase C gamma type Alpha C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000947 C00000956 C00002935 C00005548 C00009071 C00009075 C00009077 0 / 1
P24723 Protein kinase C eta type Eta C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 1 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
Q05655 Protein kinase C delta type Delta C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
P05771 Protein kinase C beta type Alpha C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
P17252 Protein kinase C alpha type Alpha C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
Q05513 Protein kinase C zeta type Iota C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
P41743 Protein kinase C iota type Iota C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
Q02156 Protein kinase C epsilon type Eta C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 0
Q04759 Protein kinase C theta type Delta C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 C00009098 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 1 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000947 C00000956 C00002935 C00009071 C00009075 C00009077 3 / 3
O75496 Geminin Unclassified protein C00000723 C00002707 C00005373 C00005548 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00002935 C00009071 C00009075 C00009077 0 / 0
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00002935 C00009071 C00009075 C00009077 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000947 C00000956 C00005373 C00005548 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00000947 C00000956 C00005373 0 / 1
Q16637 Survival motor neuron protein Unclassified protein C00000947 C00000956 C00005373 4 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00000947 C00000956 C00005373 4 / 3
P35372 Mu-type opioid receptor Opioid receptor C00000947 C00000956 C00005373 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000947 C00000956 C00005373 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000947 C00000956 C00005373 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000947 C00000956 C00005373 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000947 C00000956 C00005373 0 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000947 C00000956 C00005373 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000947 C00000956 C00005373 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000947 C00000956 C00005373 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000947 C00000956 C00005373 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000947 C00000956 C00005373 3 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00000947 C00000956 C00005373 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000947 C00000956 C00005373 1 / 1
P06746 DNA polymerase beta Enzyme C00000947 C00000956 C00005373 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000947 C00000956 C00005373 1 / 1
P41143 Delta-type opioid receptor Opioid receptor C00000947 C00000956 C00005373 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000947 C00000956 C00005373 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000947 C00000956 C00005373 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000947 C00000956 0 / 0
P07998 Ribonuclease pancreatic Enzyme C00000947 C00000956 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000947 C00000956 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000947 C00000956 1 / 2
P00915 Carbonic anhydrase 1 Lyase C00000947 C00000956 0 / 0
P07711 Cathepsin L1 C1A C00000947 C00000956 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000947 C00000956 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000947 C00000956 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000947 C00000956 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00000947 C00000956 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000947 C00000956 3 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000947 C00000956 0 / 0
P00734 Prothrombin S1A C00000947 C00000956 4 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000947 C00000956 1 / 2
O00255 Menin Unclassified protein C00000947 C00000956 2 / 5
P04745 Alpha-amylase 1 Enzyme C00000947 C00000956 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000947 C00000956 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000947 C00000956 2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000947 C00000956 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000947 C00000956 2 / 3
P56817 Beta-secretase 1 A1A C00000947 C00000956 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000947 C00000956 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000947 C00000956 0 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000947 C00000956 1 / 1
P43166 Carbonic anhydrase 7 Lyase C00000947 C00000956 0 / 0
P54132 Bloom syndrome protein Enzyme C00000947 C00000956 1 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000947 C00000956 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00000947 C00000956 5 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000947 C00000956 2 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00000947 C00000956 1 / 1
P07237 Protein disulfide-isomerase Enzyme C00005373 C00005548 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000947 C00000956 0 / 0
P49327 Fatty acid synthase Transferase C00000947 C00000956 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000947 C00000956 0 / 0
P02768 Serum albumin Secreted protein C00000947 C00000956 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000947 C00000956 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000947 C00000956 3 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000947 C00000956 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000947 C00000956 1 / 0
P00918 Carbonic anhydrase 2 Lyase C00000947 C00000956 1 / 2
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000947 C00000956 5 / 1
P28907 ADP-ribosyl cyclase 1 Enzyme C00000947 C00000956 0 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000947 C00000956 0 / 7
P07451 Carbonic anhydrase 3 Lyase C00000947 C00000956 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000947 C00000956 3 / 2
P22748 Carbonic anhydrase 4 Lyase C00000947 C00000956 1 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000947 C00000956 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
P03372 Estrogen receptor NR3A1 C00005548 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005548 0 / 0
O00167 Eyes absent homolog 2 Enzyme C00002707 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 2 / 0
P08253 72 kDa type IV collagenase M10A C00009098 1 / 3
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
P14679 Tyrosinase Oxidoreductase C00005373 4 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005373 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005373 1 / 4
P83916 Chromobox protein homolog 1 Unclassified protein C00002707 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005548 0 / 0
P15121 Aldose reductase Enzyme C00005373 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00000723 2 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005373 1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005373 11 / 10
P14780 Matrix metalloproteinase-9 M10A C00009098 2 / 2
P04062 Glucosylceramidase Enzyme C00005373 6 / 4
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005373 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 1 / 0

93 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000947 C00009077
581 BAX, BCL2L4 BCL2-associated X protein C00000947 C00009077
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000947 C00009077
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000947 C00009077
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000947 C00009077
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000947 C00009077
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000947 C00009077
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000947 C00009077
7916 PRRC2A, BAT2, D6S51, D6S51E, G2 proline-rich coiled-coil 2A C00000947
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00009077
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000947
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00000947
393 ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 Rho GTPase activating protein 4 C00000947
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00000947
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000947
2683 B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) C00000947
56751 BARHL1 BarH-like homeobox 1 C00000947
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000947
637 BID, FP497 BH3 interacting domain death agonist C00000947
388962 BOLA3, MMDS2 bolA family member 3 C00000947
79184 BRCC3, BRCC36, C6.1A, CXorf53 BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) C00000947
694 BTG1 B-cell translocation gene 1, anti-proliferative C00000947
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000947
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000947
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000947
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000947
930 CD19, B4, CVID3 CD19 molecule C00000947
975 CD81, CVID6, S5.7, TAPA1, TSPAN28 CD81 molecule C00000947
928 CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 CD9 molecule C00000947
1054 CEBPG, GPE1BP, IG/EBP-1 CCAAT/enhancer binding protein (C/EBP), gamma C00000947
10978 CLP1, HEAB, hClp1 cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) C00000947
10063 COX17 COX17 cytochrome c oxidase copper chaperone C00000947
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00000947
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000947
7913 DEK, D6S231E DEK oncogene C00000947
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00000947
2130 EWSR1, EWS, bK984G1.4 EWS RNA-binding protein 1 C00000947
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000947
2323 FLT3LG, FL, FLT3L fms-related tyrosine kinase 3 ligand C00000947
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00000947
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00000947
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000947
3054 HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF host cell factor C1 (VP16-accessory protein) C00000947
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000947
3232 HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 homeobox D3 C00000947
3329 HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 heat shock 60kDa protein 1 (chaperonin) C00000947
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000947
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00000947
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000947
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00000947
9235 IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd interleukin 32 C00000947
3662 IRF4, LSIRF, MUM1, NF-EM5 interferon regulatory factor 4 C00000947
3683 ITGAL, CD11A, LFA-1, LFA1A integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) C00000947
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00000947
4067 LYN, JTK8, p53Lyn, p56Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) C00000947
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00000947
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00000947
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00000947
64975 MRPL41, BMRP, MRP-L27, MRPL27, RPML27 mitochondrial ribosomal protein L41 C00000947
4493 MT1E, MT1, MTD metallothionein 1E C00000947
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00000947
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000947
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000947
4851 NOTCH1, TAN1, hN1 notch 1 C00000947
4869 NPM1, B23, NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) C00000947
5175 PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM platelet/endothelial cell adhesion molecule 1 C00000947
5187 PER1, PER, RIGUI, hPER period circadian clock 1 C00000947
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000947
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00000947
4240 MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 milk fat globule-EGF factor 8 protein C00009077
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000947
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000947
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000947
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000947
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000947
6128 RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 ribosomal protein L6 C00000947
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00000947
6286 S100P, MIG9 S100 calcium binding protein P C00000947
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000947
7536 SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 splicing factor 1 C00000947
6574 SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 solute carrier family 20 (phosphate transporter), member 1 C00000947
6699 SPRR1B, CORNIFIN, GADD33, SPRR1 small proline-rich protein 1B C00000947
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000947
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000947
6778 STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C signal transducer and activator of transcription 6, interleukin-4 induced C00000947
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000947
6932 TCF7, TCF-1 transcription factor 7 (T-cell specific, HMG-box) C00000947
7083 TK1, TK2 thymidine kinase 1, soluble (EC:2.7.1.21) C00000947
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000947
943 TNFRSF8, CD30, D1S166E, Ki-1 tumor necrosis factor receptor superfamily, member 8 C00000947
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00000947
2829 XCR1, CCXCR1, GPR5 chemokine (C motif) receptor 1 C00000947
51042 ZNF593, ZT86 zinc finger protein 593 C00000947

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (93)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (79)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00028 Choriocarcinoma P08253 (related)
P10415 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
P28907 (marker)
H00013 Small cell lung cancer P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

13 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D050197 Atherosclerosis C00000947
D001943 Breast Neoplasms C00000947
D002471 Cell Transformation, Neoplastic C00000947
D003556 Cystitis C00000947
D056486 Drug-Induced Liver Injury C00000947
D034381 Hearing Loss C00000947
D006331 Heart Diseases C00000947
D020138 HYPERHOMOCYSTEINEMIA C00000947
D008107 Liver Diseases C00000947
D017114 Liver Failure, Acute C00000947
D008113 Liver Neoplasms C00000947
D008325 Mammary Neoplasms, Experimental C00000947
D009362 Neoplasm Metastasis C00000947