Species

KNApSAcK Entry

Organism name Cocos nucifera
Genus Cocos
Family Palmae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cocos nucifera
Linked NCBI taxonomy ID 13894
Linked level species

Family

Family in NCBI taxonomy Arecaceae
ID 4710

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003653 External link 512 Fucosterol
/ (24R)24-Ethylcholesta-5,24(28)-dien-3beta-ol
CHEMBL519971
CHEMBL1836654
C015896
No. 53 No. 11
C00001173 External link 512 Sorbitol
/ D-Sorbitol
/ D-Glucitol
/ (-)-Sorbitol
CHEMBL16105
CHEMBL689
CHEMBL1682
CHEMBL1735282
CHEMBL1773904
D013012
101 / 49 / 42 8 / 5 No. 630
C00000096 External link 512 9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside
No. 989
C00001213 External link 512 Capric acid
/ Decanoic acid
/ n-Decanoic acid
CHEMBL107498
C031071
8 / 11 / 6 4 / 0 No. 1141 No. 68
C00001231 External link 512 Caprylic acid
/ Octanoic acid
/ n-Octanoic acid
CHEMBL324846
C031492
10 / 14 / 13 2 / 1 No. 1141 No. 68
C00001318 External link 512 gamma-Nonalactone
CHEMBL191935
3 / 3 / 1 No. 1374
C00000091 External link 512 trans-Zeatin
CHEMBL525239
D015026
2 / 3 / 2 0 / 1 No. 2879
C00001218 External link 512 Caproic acid
/ Hexanoic acid
/ 1-Hexanoic acid
/ n-Hexanoic acid
CHEMBL14184
C037652
5 / 0 / 0 No. 3692 No. 68

Human Protein / Gene in interactions

116 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00001213 C00001218 C00001231 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000091 C00001213 C00001231 3 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00001213 C00001218 C00001231 0 / 0
O75496 Geminin Unclassified protein C00001173 C00001213 C00001231 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001173 C00001213 C00001231 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001173 C00001318 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001173 C00001318 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001173 C00001231 11 / 10
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001173 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001173 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001173 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001173 0 / 0
P29466 Caspase-1 C14 C00001173 0 / 0
P17252 Protein kinase C alpha type Alpha C00001173 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001173 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001173 2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter C00001173 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001173 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001173 0 / 3
P10828 Thyroid hormone receptor beta NR1A2 C00001318 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00001173 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001173 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001173 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001173 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001173 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001173 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001173 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001173 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001173 0 / 0
P08183 Multidrug resistance protein 1 drug C00001173 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001173 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001173 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001173 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001173 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001173 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00001173 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001173 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001173 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001173 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001173 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001173 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001173 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001173 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001173 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001173 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001231 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001173 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001173 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001173 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001173 0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00001231 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001173 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001173 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001173 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001173 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001173 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001173 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001173 0 / 1
P08246 Neutrophil elastase S1A C00001173 2 / 1
P15121 Aldose reductase Enzyme C00001218 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001173 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001173 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001173 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001173 0 / 0
P08311 Cathepsin G S1A C00001173 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001173 1 / 0
P03956 Interstitial collagenase M10A C00001173 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001173 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001218 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001173 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00001231 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001173 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001173 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001173 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001173 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001173 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001173 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001213 5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001173 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001173 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001173 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001173 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001173 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001173 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001173 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001173 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001173 2 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001173 1 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00001213 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00001213 3 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001173 0 / 0
P03372 Estrogen receptor NR3A1 C00001173 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001173 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001173 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001173 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001173 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001173 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001173 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001173 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001173 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001173 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001173 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001173 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001173 0 / 0
P10323 Acrosin S1A C00001173 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001173 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001173 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001173 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001173 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001173 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001173 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001173 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001218 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000091 0 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter C00001231 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001173 1 / 1

13 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00001213 C00001231
1978 EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I eukaryotic translation initiation factor 4E binding protein 1 C00001173
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001213
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00001213
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001231
1977 EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F eukaryotic translation initiation factor 4E C00001173
9076 CLDN1, CLD1, ILVASC, SEMP1 claudin 1 C00001213
5602 MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK mitogen-activated protein kinase 10 (EC:2.7.11.24) C00001173
6300 MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3 mitogen-activated protein kinase 12 (EC:2.7.11.24) C00001173
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00001173
9261 MAPKAPK2, MAPKAP-K2, MK-2, MK2 mitogen-activated protein kinase-activated protein kinase 2 (EC:2.7.11.1) C00001173
8569 MKNK1, MNK1 MAP kinase interacting serine/threonine kinase 1 (EC:2.7.11.1) C00001173
51035 UBXN1, 2B28, SAKS1, UBXD10 UBX domain protein 1 C00001173

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (61)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (47)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003128 COMA C00001231
D048909 Diabetes Complications C00001173
D003929 Diabetic Neuropathies C00001173
D004660 Encephalitis C00001173
D010146 Pain C00001173
D010523 Peripheral Nervous System Diseases C00001173
D000647 Amnesia C00000091