PCIDB

Dolichos lablab

Species

KNApSAcK Entry

Organism name Dolichos lablab
Genus Dolichos
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lablab purpureus
Linked NCBI taxonomy ID 35936
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000178 External link 512 28-Homodolicholide
No. 68 No. 11
C00000201 External link 512 6-Deoxodolichosterone
No. 68 No. 11
C00000199 External link 512 6-Deoxocastasterone
No. 68 No. 11
C00000193 External link 512 Homodolichosterone
/ 28-Homodolichosterone
/ 28-Methyldolichosterone
No. 68 No. 11
C00000192 External link 512 Dolichosterone
No. 68 No. 11
C00000176 External link 512 Brassinolide
CHEMBL563853
CHEMBL1801925
CHEMBL1967970
C023623
16 / 2 No. 68 No. 11
C00000177 External link 512 Dolicholide
No. 68 No. 11
C00000181 External link 512 Castasterone
C083545
No. 68 No. 11
C00000218 External link 512 Jasmonic acid
/ trans-Jasmonic acid
/ 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid
CHEMBL445499
CHEMBL449572
C011006
4 / 1 / 0 No. 707 No. 70
C00000096 External link 512 9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside
No. 989
C00000095 External link 512 9-Ribosyl-cis-zeatin
/ 6-(4-Hydroxy-3-methyl-cis-2-butenylamino)-9-beta-D-ribofuranosylpurine
No. 989
C00000100 External link 512 IAA
/ Indole-3-acetic acid
CHEMBL82411
C030737
3 / 0 / 0 2 / 1 No. 1432 No. 4
C00000091 External link 512 trans-Zeatin
CHEMBL525239
D015026
2 / 3 / 2 0 / 1 No. 2879
C00000101 External link 512 IAA methyl ester
/ Methyl indole-3-acetate
No. 4225

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000218 1 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00000100 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000091 3 / 2
P02768 Serum albumin Secreted protein C00000100 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000218 0 / 0
Q9HBH1 Peptide deformylase, mitochondrial Enzyme C00000100 0 / 0
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000218 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000218 1 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000091 0 / 0

18 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000176
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00000176
637 BID, FP497 BH3 interacting domain death agonist C00000176
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000176
891 CCNB1, CCNB cyclin B1 C00000176
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000176
898 CCNE1, CCNE cyclin E1 C00000176
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000176
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00000176
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000176
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000176
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000176
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000176
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00000176
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000176
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000176
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000100
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000100

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473

KEGG DISEASE (2)

KEGG name UniProt
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001943 Breast Neoplasms C00000176
D011471 Prostatic Neoplasms C00000176
D056486 Drug-Induced Liver Injury C00000100
D000647 Amnesia C00000091