Organism name | Cinnamomum cassia Blume. |
---|---|
Genus | Cinnamomum |
Family | Lauraceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Cinnamomum |
---|---|
Linked NCBI taxonomy ID | 13428 |
Linked level | genus |
Family in NCBI taxonomy | Lauraceae |
---|---|
ID | 3433 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | Magnoliophyta |
---|---|
ID | 3398 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00009076 |
Procyanidin B5
/ Epicatechin-(4beta-6)-epicatechin |
CHEMBL506487
CHEMBL502984 CHEMBL451115 |
No. 16 | No. 19 | ||||
C00009074 |
Procyanidin B7
/ Catechin-(4beta->6)-catechin |
CHEMBL506487
CHEMBL502984 CHEMBL451115 |
No. 16 | No. 19 | ||||
C00009075 |
Procyanidin B1
/ Epicatechin-(4beta->8)-catechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479579
|
20 / 7 / 8 | No. 16 | No. 19 | ||
C00009077 |
Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479580
|
20 / 7 / 8 | 10 / 0 | No. 16 | No. 19 | |
C00009098 |
Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin |
CHEMBL290632
|
13 / 5 / 6 | No. 29 | No. 19 | |||
C00000956 |
(-)-Epicatechin
|
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
85 / 58 / 54 | No. 52 | No. 14 |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
Q04759 | Protein kinase C theta type | Delta | C00000956 C00009075 C00009077 C00009098 | 0 / 1 |
Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
P41743 | Protein kinase C iota type | Iota | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
P24723 | Protein kinase C eta type | Eta | C00000956 C00009075 C00009077 C00009098 | 1 / 0 |
P05771 | Protein kinase C beta type | Alpha | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
P05129 | Protein kinase C gamma type | Alpha | C00000956 C00009075 C00009077 C00009098 | 1 / 1 |
Q05655 | Protein kinase C delta type | Delta | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
P17252 | Protein kinase C alpha type | Alpha | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
Q02156 | Protein kinase C epsilon type | Eta | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
Q05513 | Protein kinase C zeta type | Iota | C00000956 C00009075 C00009077 C00009098 | 0 / 0 |
P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000956 C00009075 C00009077 | 1 / 0 |
P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000956 C00009075 C00009077 | 0 / 1 |
P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000956 C00009075 C00009077 | 1 / 1 |
P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000956 C00009075 C00009077 | 0 / 0 |
P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000956 C00009075 C00009077 | 0 / 1 |
P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000956 C00009075 C00009077 | 0 / 0 |
Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000956 C00009075 C00009077 | 3 / 3 |
P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00009075 C00009077 | 0 / 0 |
P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | C00009075 C00009077 | 0 / 0 |
P10636 | Microtubule-associated protein tau | Unclassified protein | C00000956 | 4 / 3 |
P02768 | Serum albumin | Secreted protein | C00000956 | 0 / 0 |
P54132 | Bloom syndrome protein | Enzyme | C00000956 | 1 / 2 |
P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000956 | 0 / 0 |
P11473 | Vitamin D3 receptor | NR1I1 | C00000956 | 2 / 3 |
P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000956 | 0 / 0 |
P41145 | Kappa-type opioid receptor | Opioid receptor | C00000956 | 0 / 0 |
P23280 | Carbonic anhydrase 6 | Lyase | C00000956 | 0 / 0 |
Q9Y3R4 | Sialidase-2 | Enzyme | C00000956 | 0 / 0 |
Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000956 | 0 / 0 |
P00352 | Retinal dehydrogenase 1 | Enzyme | C00000956 | 0 / 0 |
O43570 | Carbonic anhydrase 12 | Lyase | C00000956 | 1 / 2 |
P39748 | Flap endonuclease 1 | Enzyme | C00000956 | 0 / 0 |
P07998 | Ribonuclease pancreatic | Enzyme | C00000956 | 0 / 0 |
P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000956 | 2 / 0 |
P41143 | Delta-type opioid receptor | Opioid receptor | C00000956 | 0 / 0 |
P00915 | Carbonic anhydrase 1 | Lyase | C00000956 | 0 / 0 |
P07711 | Cathepsin L1 | C1A | C00000956 | 0 / 0 |
Q9Y253 | DNA polymerase eta | Enzyme | C00000956 | 1 / 1 |
P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000956 | 0 / 0 |
P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000956 | 3 / 1 |
O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000956 | 0 / 0 |
P00734 | Prothrombin | S1A | C00000956 | 4 / 2 |
P04745 | Alpha-amylase 1 | Enzyme | C00000956 | 0 / 0 |
P00918 | Carbonic anhydrase 2 | Lyase | C00000956 | 1 / 2 |
P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000956 | 2 / 3 |
P28482 | Mitogen-activated protein kinase 1 | Erk | C00000956 | 0 / 0 |
P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000956 | 0 / 1 |
P56817 | Beta-secretase 1 | A1A | C00000956 | 0 / 0 |
P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000956 | 1 / 1 |
Q16790 | Carbonic anhydrase 9 | Lyase | C00000956 | 0 / 1 |
P08253 | 72 kDa type IV collagenase | M10A | C00009098 | 1 / 3 |
P16473 | Thyrotropin receptor | Glycohormone receptor | C00000956 | 3 / 2 |
P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000956 | 2 / 2 |
Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000956 | 5 / 2 |
P00374 | Dihydrofolate reductase | Oxidoreductase | C00000956 | 1 / 1 |
P35372 | Mu-type opioid receptor | Opioid receptor | C00000956 | 0 / 0 |
P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000956 | 0 / 1 |
P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000956 | 0 / 0 |
Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00000956 | 0 / 0 |
P14780 | Matrix metalloproteinase-9 | M10A | C00009098 | 2 / 2 |
P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00000956 | 0 / 0 |
Q9UNA4 | DNA polymerase iota | Enzyme | C00000956 | 0 / 0 |
Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000956 | 1 / 0 |
P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000956 | 0 / 0 |
P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000956 | 5 / 1 |
P49327 | Fatty acid synthase | Transferase | C00000956 | 0 / 0 |
P07451 | Carbonic anhydrase 3 | Lyase | C00000956 | 0 / 0 |
P22748 | Carbonic anhydrase 4 | Lyase | C00000956 | 1 / 1 |
P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00000956 | 0 / 7 |
Q9UBT6 | DNA polymerase kappa | Enzyme | C00000956 | 0 / 0 |
B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000956 | 0 / 0 |
P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000956 | 0 / 0 |
Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000956 | 0 / 0 |
Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000956 | 1 / 1 |
O00255 | Menin | Unclassified protein | C00000956 | 2 / 5 |
Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000956 | 1 / 2 |
P43166 | Carbonic anhydrase 7 | Lyase | C00000956 | 0 / 0 |
P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000956 | 0 / 0 |
Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000956 | 0 / 0 |
P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000956 | 1 / 1 |
P06746 | DNA polymerase beta | Enzyme | C00000956 | 0 / 0 |
Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000956 | 3 / 0 |
P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000956 | 0 / 3 |
Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000956 | 0 / 0 |
Q16637 | Survival motor neuron protein | Unclassified protein | C00000956 | 4 / 1 |
P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000956 | 0 / 0 |
P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000956 | 3 / 0 |
Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000956 | 0 / 0 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00009077
|
581 | BAX, BCL2L4 | BCL2-associated X protein |
C00009077
|
836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00009077
|
842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00009077
|
54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00009077
|
2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00009077
|
5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00009077
|
5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00009077
|
4240 | MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 | milk fat globule-EGF factor 8 protein |
C00009077
|
7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00009077
|
OMIM | preferred title | UniProt |
---|---|---|
#300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
#600807 | Asthma, susceptibility to |
Q13093
|
#608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
#601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
#210900 | Bloom syndrome; blm |
P54132
|
#118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
#118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
#114500 | Colorectal cancer; crc |
P84022
|
#218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
#606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
#119900 | Digital clubbing, isolated congenital |
P15428
|
#609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
#608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
#600274 | Frontotemporal dementia; ftd |
P10636
|
#143500 | Gilbert syndrome |
P22309
P22310 |
#232300 | Glycogen storage disease ii |
P10253
|
#139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
#605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
#114550 | Hepatocellular carcinoma |
P08581
|
#237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
#143860 | Hyperchlorhidrosis, isolated |
O43570
|
#145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
#603373 | Hyperthyroidism, familial gestational |
P16473
|
#609152 | Hyperthyroidism, nonautoimmune |
P16473
|
#145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
#259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
#146300 | Hypophosphatasia, adult |
P05186
|
#241510 | Hypophosphatasia, childhood |
P05186
|
#241500 | Hypophosphatasia, infantile |
P05186
|
#275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
#147050 | Ige responsiveness, atopic; iger |
Q13093
|
#603932 | Intervertebral disc disease; idd |
P14780
|
#613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
#613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
#300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
#300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
#613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
#259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
#131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
#607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
#162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
#259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
#260540 | Parkinson-dementia syndrome |
P10636
|
#172700 | Pick disease of brain |
P10636
|
#614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
#614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
#613679 | Prothrombin deficiency, congenital |
P00734
|
#605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
#600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
#253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
#253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
#253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
#271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
#605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
#607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
#601367 | Stroke, ischemic |
P00734
P24723 |
#601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
#188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
#277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
#278300 | Xanthinuria, type i |
P47989
|
#278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG | name | UniProt |
---|---|---|
H00033 | Adrenal carcinoma |
O00255
(related)
|
H00034 | Carcinoid |
O00255
(related)
|
H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
H00246 | Primary hyperparathyroidism |
O00255
(related)
|
H01102 | Pituitary adenomas |
O00255
(related)
|
H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
H00021 | Renal cell carcinoma |
O43570
(marker)
P08581 (related) Q16790 (marker) |
H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
H00223 | Inherited thrombophilia |
P00734
(related)
|
H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
H00436 | Osteopetrosis |
P00918
(related)
|
H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
H00213 | Hypophosphatasia |
P05186
(related)
|
H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
H00028 | Choriocarcinoma |
P08253
(related)
P10415 (related) |
H00472 | Torg-Winchester syndrome |
P08253
(related)
|
H00018 | Gastric cancer |
P08581
(related)
P10415 (related) |
H00046 | Cholangiocarcinoma |
P08581
(related)
P35354 (related) |
H00036 | Osteosarcoma |
P08684
(marker)
|
H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
P28907 (marker) |
H00013 | Small cell lung cancer |
P10415
(related)
|
H00030 | Cervical cancer |
P10415
(related)
|
H00041 | Kaposi's sarcoma |
P10415
(related)
|
H00054 | Nasopharyngeal cancer |
P10415
(related)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
H00023 | Testicular cancer |
P10696
(marker)
|
H00342 | Tuberculosis |
P11473
(related)
|
H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
H01205 | Coumarin resistance |
P11712
(related)
|
H00479 | Metaphyseal dysplasias |
P14780
(related)
|
H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
H01269 | Congenital hyperthyroidism |
P16473
(related)
|
H00208 | Hyperbilirubinemia |
P22309
(related)
|
H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
H00017 | Esophageal cancer |
P35354
(related)
|
H00192 | Xanthinuria |
P47989
(related)
|
H00094 | DNA repair defects |
P54132
(related)
|
H00296 | Defects in RecQ helicases |
P54132
(related)
|
H00264 | Charcot-Marie-Tooth disease (CMT) |
Q01453
(related)
|
H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
H00408 | Type I diabetes mellitus |
Q04759
(related)
|
H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|