Species

KNApSAcK Entry

Organism name Cinnamomum cassia Blume.
Genus Cinnamomum
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cinnamomum
Linked NCBI taxonomy ID 13428
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009076 External link 512 Procyanidin B5
/ Epicatechin-(4beta-6)-epicatechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00009074 External link 512 Procyanidin B7
/ Catechin-(4beta->6)-catechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00009075 External link 512 Procyanidin B1
/ Epicatechin-(4beta->8)-catechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479579
20 / 7 / 8 No. 16 No. 19
C00009077 External link 512 Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479580
20 / 7 / 8 10 / 0 No. 16 No. 19
C00009098 External link 512 Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin
CHEMBL290632
13 / 5 / 6 No. 29 No. 19
C00000956 External link 512 (-)-Epicatechin
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
85 / 58 / 54 No. 52 No. 14

Human Protein / Gene in interactions

89 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q04759 Protein kinase C theta type Delta C00000956 C00009075 C00009077 C00009098 0 / 1
Q15139 Serine/threonine-protein kinase D1 Pkd C00000956 C00009075 C00009077 C00009098 0 / 0
P41743 Protein kinase C iota type Iota C00000956 C00009075 C00009077 C00009098 0 / 0
P24723 Protein kinase C eta type Eta C00000956 C00009075 C00009077 C00009098 1 / 0
P05771 Protein kinase C beta type Alpha C00000956 C00009075 C00009077 C00009098 0 / 0
P05129 Protein kinase C gamma type Alpha C00000956 C00009075 C00009077 C00009098 1 / 1
Q05655 Protein kinase C delta type Delta C00000956 C00009075 C00009077 C00009098 0 / 0
P17252 Protein kinase C alpha type Alpha C00000956 C00009075 C00009077 C00009098 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000956 C00009075 C00009077 C00009098 0 / 0
Q02156 Protein kinase C epsilon type Eta C00000956 C00009075 C00009077 C00009098 0 / 0
Q05513 Protein kinase C zeta type Iota C00000956 C00009075 C00009077 C00009098 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000956 C00009075 C00009077 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000956 C00009075 C00009077 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000956 C00009075 C00009077 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00000956 C00009075 C00009077 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000956 C00009075 C00009077 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000956 C00009075 C00009077 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000956 C00009075 C00009077 3 / 3
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00009075 C00009077 0 / 0
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00009075 C00009077 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000956 4 / 3
P02768 Serum albumin Secreted protein C00000956 0 / 0
P54132 Bloom syndrome protein Enzyme C00000956 1 / 2
P11388 DNA topoisomerase 2-alpha Isomerase C00000956 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000956 2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000956 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000956 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000956 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00000956 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000956 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000956 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000956 1 / 2
P39748 Flap endonuclease 1 Enzyme C00000956 0 / 0
P07998 Ribonuclease pancreatic Enzyme C00000956 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000956 2 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000956 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000956 0 / 0
P07711 Cathepsin L1 C1A C00000956 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000956 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00000956 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000956 3 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000956 0 / 0
P00734 Prothrombin S1A C00000956 4 / 2
P04745 Alpha-amylase 1 Enzyme C00000956 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000956 1 / 2
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000956 2 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000956 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00000956 0 / 1
P56817 Beta-secretase 1 A1A C00000956 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000956 1 / 1
Q16790 Carbonic anhydrase 9 Lyase C00000956 0 / 1
P08253 72 kDa type IV collagenase M10A C00009098 1 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00000956 3 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000956 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00000956 5 / 2
P00374 Dihydrofolate reductase Oxidoreductase C00000956 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00000956 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000956 0 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000956 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000956 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00009098 2 / 2
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000956 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000956 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000956 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000956 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000956 5 / 1
P49327 Fatty acid synthase Transferase C00000956 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000956 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000956 1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000956 0 / 7
Q9UBT6 DNA polymerase kappa Enzyme C00000956 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000956 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000956 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000956 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000956 1 / 1
O00255 Menin Unclassified protein C00000956 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000956 1 / 2
P43166 Carbonic anhydrase 7 Lyase C00000956 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000956 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000956 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000956 1 / 1
P06746 DNA polymerase beta Enzyme C00000956 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000956 3 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000956 0 / 3
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000956 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000956 4 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000956 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000956 3 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000956 0 / 0

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00009077
581 BAX, BCL2L4 BCL2-associated X protein C00009077
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00009077
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00009077
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00009077
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00009077
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00009077
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00009077
4240 MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 milk fat globule-EGF factor 8 protein C00009077
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00009077

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (61)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#600852 Retinitis pigmentosa 17; rp17 P22748
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (56)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00028 Choriocarcinoma P08253 (related)
P10415 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
P28907 (marker)
H00013 Small cell lung cancer P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)