Species

KNApSAcK Entry

Organism name Morus cathayana
Genus Morus
Family Moraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Morus cathayana
Linked NCBI taxonomy ID 226895
Linked level species

Family

Family in NCBI taxonomy Moraceae
ID 3487

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (29)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019324 External link 512 Sanggenol B
No. 14 No. 15
C00047788 External link 512 Cathafuran C
CHEMBL550963
No. 18 No. 15
C00014187 External link 512 Sanggenol A
/ 5,7,2',4'-Tetrahydroxy-3'-geranylflavanone
No. 19 No. 14
C00047789 External link 512 Cathafuran D
/ (-)-Cathafuran D
No. 47 No. 15
C00001000 External link 512 Sanggenon C
CHEMBL204813
CHEMBL525084
C477157
2 / 0 / 0 No. 81 No. 20
C00014568 External link 512 Cathayanon B
/ Cathayanone B
No. 81 No. 20
C00014567 External link 512 Cathayanon A
/ Cathayanone A
No. 81 No. 20
C00001001 External link 512 Sanggenon D
CHEMBL464610
CHEMBL1588549
15 / 18 / 12 No. 81 No. 20
C00014563 External link 512 Sanggenol J
No. 81 No. 20
C00014399 External link 512 Sanggenol H
CHEMBL1773620
No. 170 No. 14
C00014387 External link 512 Sanggenol D
/ 3,5,7,2',4'-Pentahydroxy-5'-prenyl-3'-geranylflavanone
No. 170 No. 14
C00014388 External link 512 Sanggenol E
/ 3,5,7,2',4'-Pentahydroxy-8,5'-diprenyl-3'-geranylflavanone
No. 170 No. 14
C00014397 External link 512 Sanggenol I
No. 170 No. 14
C00014398 External link 512 Sanggenol G
No. 170 No. 14
C00014386 External link 512 Sanggenol K
/ 3,5,7,2',4'-Pentahydroxy-6-prenyl-3'-geranylflavanone
No. 170 No. 14
C00014384 External link 512 Sanggenol C
/ 3,5,7,4'-Tetrahydroxy-8-prenyl-3'-geranylflavanone
No. 170 No. 14
C00049296 External link 512 Sanggenol F
No. 170 No. 14
C00036709 External link 512 alpha-Amyrin acetate
CHEMBL471754
C000265
No. 177
C00047787 External link 512 Cathafuran B
CHEMBL561161
No. 319 No. 15
C00047786 External link 512 Cathafuran A
No. 319 No. 15
C00019325 External link 512 Mulberrofuran V
/ 6,3',5'-Trihydroxy-2',6'-diprenyl-2-arylbenzofuran
No. 319 No. 15
C00002499 External link 512 Scopoletin
CHEMBL71851
D012603
48 / 37 / 34 9 / 0 No. 864 No. 25
C00002503 External link 512 Umbelliferon
/ Umbelliferone
/ 7-Hydroxycoumarin
CHEMBL51628
C031477
39 / 33 / 32 9 / 0 No. 1030 No. 25
C00008634 External link 512 Sanggenon L
No. 1072
C00008629 External link 512 Sanggenon M
No. 1072
C00008628 External link 512 Sanggenon A
CHEMBL1517104
8 / 9 / 4 No. 1072
C00036577 External link 512 4-Hydroxy-3,5-dimethoxybenzyl alcohol
No. 1412
C00037512 External link 512 Moracin O
/ (-)-Moracin O
CHEMBL205924
CHEMBL1795432
3 / 0 / 0 No. 3977
C00019263 External link 512 Mulberroside C
No. 8424

Human Protein / Gene in interactions

69 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00001001 C00002499 C00002503 C00008628 1 / 1
O75496 Geminin Unclassified protein C00001001 C00002499 C00002503 C00008628 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001001 C00002499 C00002503 0 / 3
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00001000 C00002499 C00037512 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001001 C00008628 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002499 C00002503 1 / 2
O00255 Menin Unclassified protein C00002499 C00002503 2 / 5
Q00796 Sorbitol dehydrogenase Enzyme C00002499 C00002503 0 / 0
P04062 Glucosylceramidase Enzyme C00002499 C00002503 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00002499 C00002503 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001001 C00008628 1 / 0
P29466 Caspase-1 C14 C00002499 C00002503 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002499 C00002503 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001001 C00002499 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002499 C00002503 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002499 C00002503 5 / 1
P37840 Alpha-synuclein Unclassified protein C00001001 C00008628 4 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002499 C00002503 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002499 C00002503 1 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00001000 C00037512 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002499 C00002503 0 / 0
P55210 Caspase-7 C14 C00002499 C00002503 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002499 C00002503 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002499 C00002503 1 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002499 C00002503 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002499 C00002503 1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002499 C00037512 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002499 C00002503 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002499 C00002503 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001001 C00008628 2 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002499 C00002503 3 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002499 C00002503 2 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002499 C00002503 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002499 C00002503 3 / 3
P15121 Aldose reductase Enzyme C00002499 C00002503 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002499 C00002503 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001001 C00008628 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001001 C00002499 7 / 3
Q16790 Carbonic anhydrase 9 Lyase C00002499 C00002503 0 / 1
P06280 Alpha-galactosidase A Enzyme C00002499 C00002503 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002499 1 / 0
P14679 Tyrosinase Oxidoreductase C00002503 4 / 2
Q9Y253 DNA polymerase eta Enzyme C00001001 1 / 1
P56817 Beta-secretase 1 A1A C00002503 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002499 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00002499 0 / 0
P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Oxidoreductase C00002503 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002499 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002503 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001001 2 / 2
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00002503 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002503 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001001 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002499 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002499 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001001 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002499 0 / 1
P55789 FAD-linked sulfhydryl oxidase ALR Enzyme C00002499 1 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00002503 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001001 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00002499 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002499 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002499 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002503 1 / 1
P43166 Carbonic anhydrase 7 Lyase C00002499 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002499 0 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00002499 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002503 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00008628 1 / 1

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002499 C00002503
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002499 C00002503
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00002503
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002503
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002503
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002503
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002503
8574 AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) C00002503
581 BAX, BCL2L4 BCL2-associated X protein C00002503
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002499
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002499
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002499
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00002499
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002499
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002499
7508 XPC, RAD4, XP3, XPCC xeroderma pigmentosum, complementation group C C00002499

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (54)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#218030 Apparent mineralocorticoid excess; ame P80365
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#114500 Colorectal cancer; crc P84022
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613076 Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay P55789
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)