Cycas revoluta
Species
KNApSAcK Entry
| Organism name | Cycas revoluta |
|---|---|
| Genus | Cycas |
| Family | Cycadaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cycas revoluta |
|---|---|
| Linked NCBI taxonomy ID | 3396 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cycadaceae |
|---|---|
| ID | 3394 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Spermatophyta |
|---|---|
| ID | 58024 |
Natural Activity
List (7)
| Species | Activity |
|---|---|
| Cycas revoluta Thunb. | Antirheumatic |
| Cycas revoluta Thunb. | Astringent |
| Cycas revoluta Thunb. | Diuretic |
| Cycas revoluta Thunb. | Emmenagogue |
| Cycas revoluta Thunb. | Expectorant |
| Cycas revoluta Thunb. | Tonic |
| Cycas revoluta Thunb. | Tumorigenic |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001015
|
Amentoflavone
|
CHEMBL63354
|
C011164
|
50 / 39 / 29 | 5 / 0 | No. 34 | No. 18 |
|
|
C00001049
|
Hinokiflavone
|
CHEMBL291426
|
C060299
|
2 / 1 / 2 | No. 34 | No. 18 |
|
|
|
C00006539
|
2,3-Dihydrohinokiflavone
|
No. 88 |
|
|||||
|
C00006508
|
2,3-Dihydroamentoflavone
|
CHEMBL220741
|
2 / 1 / 2 | No. 88 |
|
|||
|
C00001535
|
Cycasin
|
D003492
|
No. 258 | No. 73 |
|
|||
|
C00028111
|
Cycasthioamide
|
No. 6054 |
|
Human Protein / Gene in interactions
50 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P43235 | Cathepsin K | C1A | C00001015 C00001049 C00006508 | 1 / 2 |
| P56817 | Beta-secretase 1 | A1A | C00001015 C00001049 C00006508 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001015 | 0 / 0 |
| O15496 | Group 10 secretory phospholipase A2 | Enzyme | C00001015 | 0 / 0 |
| P49763 | Placenta growth factor | Unclassified protein | C00001015 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001015 | 0 / 0 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | C00001015 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00001015 | 0 / 0 |
| P47712 | Cytosolic phospholipase A2 | Enzyme | C00001015 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001015 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001015 | 2 / 2 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001015 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001015 | 2 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001015 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001015 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001015 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001015 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001015 | 1 / 1 |
| P15692 | Vascular endothelial growth factor A | Secreted protein | C00001015 | 1 / 2 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001015 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00001015 | 1 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001015 | 2 / 2 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001015 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001015 | 0 / 0 |
| P19174 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Enzyme | C00001015 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001015 | 3 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001015 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001015 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001015 | 0 / 0 |
| P55072 | Transitional endoplasmic reticulum ATPase | Unclassified protein | C00001015 | 2 / 1 |
| O00255 | Menin | Unclassified protein | C00001015 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001015 | 1 / 2 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001015 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001015 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001015 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001015 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001015 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001015 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001015 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001015 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001015 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001015 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001015 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001015 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001015 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001015 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001015 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001015 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001015 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001015 | 2 / 1 |
5 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001015
|
| 1638 | DCT, TRP-2, TYRP2 | dopachrome tautomerase (EC:5.3.3.12) |
C00001015
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001015
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001015
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00001015
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P47869
|
| #613954 | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 |
P55072
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #167320 | Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 |
P55072
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #603933 | Microvascular complications of diabetes, susceptibility to, 1; mvcd1 |
P15692
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #265800 | Pycnodysostosis |
P43235
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (29)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00025 | Penile cancer |
P08253
(related)
|
| H00028 | Choriocarcinoma |
P08253
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
P55072 (related) |
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00018 | Gastric cancer |
P15692
(related)
|
| H00021 | Renal cell carcinoma |
P15692
(marker)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00273 | Pycnodysostosis |
P43235
(related)
|
| H00425 | Lysosomal cysteine protease deficiencies |
P43235
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|