Species

KNApSAcK Entry

Organism name Tripterygium hypoglaucum
Genus Tripterygium
Family Celastraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tripterygium hypoglaucum
Linked NCBI taxonomy ID 205465
Linked level species

Family

Family in NCBI taxonomy Celastraceae
ID 4305

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (20)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00037290 External link 512 Hypodiol
/ (-)-Hypodiol
No. 13 No. 51
C00037953 External link 512 Triptocallic acid D
CHEMBL513961
CHEMBL458310
CHEMBL482783
CHEMBL520845
CHEMBL482586
No. 13 No. 51
C00036544 External link 512 3-Epikatonic acid
CHEMBL490528
CHEMBL463266
CHEMBL482798
CHEMBL487933
No. 13 No. 51
C00013192 External link 512 Wilforgin
/ Wilforgine
/ (8alpha)-8-(Acetyloxy)-O2-deacetyl-8-deoxo-O2-(3-furanylcarbonyl)evonimine
No. 43
C00039396 External link 512 Hyponine E
No. 43
C00039395 External link 512 Hyponine D
CHEMBL504037
No. 43
C00039397 External link 512 Hyponine F
No. 43
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00036478 External link 512 29-Hydroxyfriedelan-3-one
/ (-)-29-Hydroxyfriedelan-3-one
CHEMBL516320
No. 101 No. 52
C00037952 External link 512 Triptocallic acid C
/ (+)-Triptocallic acid C
No. 101 No. 52
C00033565 External link 512 Acetyloleanolic acid
/ Oleanolic acid acetate
/ 3-O-Acetyloleanolic acid
/ (+)-Acetyloleanolic acid
/ (+)-Oleanolic acid acetate
/ (+)-3-O-Acetyloleanolic acid
/ 3beta-Acetoxyolean-12-en-28-oic acid
CHEMBL486822
CHEMBL494653
CHEMBL1315416
C052658
1 / 0 / 0 No. 177
C00001224 External link 512 Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid
CHEMBL267476
29 / 31 / 28 No. 367 No. 68
C00029919 External link 512 Celastrol
CHEMBL301982
CHEMBL1321090
CHEMBL1712082
C050414
46 / 43 / 67 100 / 0 No. 403 No. 51
C00037958 External link 512 Triptoquinone F
No. 1436
C00037956 External link 512 Triptoquinone D
No. 1436
C00037957 External link 512 Triptoquinone E
No. 1436
C00035884 External link 512 Triptoquinone H
/ (+)-Triptoquinone H
No. 1436
C00037548 External link 512 Neotriptophenolide
C035062
No. 2898
C00035773 External link 512 Hypolide
/ Triptophenolide
CHEMBL1516675
C035061
3 / 4 / 2 No. 2898
C00030109 External link 512 Demethylzeylasteral
No. 2913

Human Protein / Gene in interactions

78 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001224 C00003672 C00029919 C00035773 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001224 C00029919 C00035773 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 C00029919 2 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 C00029919 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001224 C00029919 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00029919 C00035773 4 / 1
P03372 Estrogen receptor NR3A1 C00001224 C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001224 C00029919 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001224 C00029919 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001224 C00029919 3 / 3
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00001224 C00029919 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001224 C00003672 1 / 1
O75496 Geminin Unclassified protein C00001224 C00029919 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001224 C00029919 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001224 C00003672 3 / 2
O14842 Free fatty acid receptor 1 Free fatty acid receptor C00001224 0 / 0
Q16543 Hsp90 co-chaperone Cdc37 Unclassified protein C00029919 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P37840 Alpha-synuclein Unclassified protein C00029919 4 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00033565 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001224 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00001224 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00029919 2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001224 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00029919 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001224 0 / 0
P39748 Flap endonuclease 1 Enzyme C00029919 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001224 0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme C00029919 1 / 2
Q00613 Heat shock factor protein 1 Unclassified protein C00029919 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00029919 2 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00029919 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00029919 0 / 0
P51684 C-C chemokine receptor type 6 CC chemokine receptor C00029919 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001224 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00029919 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00029919 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001224 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001224 2 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001224 5 / 3
P13726 Tissue factor Membrane receptor C00001224 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00029919 2 / 0
Q96RI1 Bile acid receptor NR1H4 C00001224 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00029919 4 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00029919 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001224 0 / 0
Q99700 Ataxin-2 Unclassified protein C00029919 1 / 1
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00029919 0 / 0
Q9NR96 Toll-like receptor 9 Toll-like and Il-1 receptors C00029919 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00029919 7 / 37
P02545 Prelamin-A/C Unclassified protein C00001224 11 / 10
Q9UNA4 DNA polymerase iota Enzyme C00029919 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00029919 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00029919 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00029919 0 / 0
P10275 Androgen receptor NR3C4 C00001224 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001224 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00029919 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00029919 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00029919 0 / 0
P35610 Sterol O-acyltransferase 1 Enzyme C00001224 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00029919 1 / 0
O00255 Menin Unclassified protein C00029919 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00029919 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00029919 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00029919 0 / 3
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00029919 2 / 1
Q06710 Paired box protein Pax-8 Unclassified protein C00029919 1 / 2

100 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10598 AHSA1, AHA1, C14orf3, p38 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) C00029919
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00029919
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00029919
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00029919
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00029919
84159 ARID5B, DESRT, MRF-2, MRF2 AT rich interactive domain 5B (MRF1-like) C00029919
467 ATF3 activating transcription factor 3 C00029919
9531 BAG3, BAG-3, BIS, CAIR-1, MFM6 BCL2-associated athanogene 3 C00029919
581 BAX, BCL2L4 BCL2-associated X protein C00029919
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00029919
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00029919
694 BTG1 B-cell translocation gene 1, anti-proliferative C00029919
8209 C21orf33, ES1, GT335, HES1, KNPH, KNPI chromosome 21 open reading frame 33 C00029919
27101 CACYBP, GIG5, RP1-102G20.6, S100A6BP, SIP calcyclin binding protein C00029919
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00029919
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00029919
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00029919
831 CAST, BS-17 calpastatin C00029919
874 CBR3, SDR21C2, hCBR3 carbonyl reductase 3 (EC:1.1.1.184) C00029919
8317 CDC7, CDC7L1, HsCDC7, Hsk1, huCDC7 cell division cycle 7 (EC:2.7.11.1) C00029919
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00029919
26973 CHORDC1, CHP1 cysteine and histidine-rich domain (CHORD) containing 1 C00029919
10370 CITED2, ASD8, MRG-1, MRG1, P35SRJ, VSD2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 C00029919
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00029919
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00029919
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00029919
3301 DNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2 DnaJ (Hsp40) homolog, subfamily A, member 1 C00029919
11080 DNAJB4, DNAJW, DjB4, HLJ1 DnaJ (Hsp40) homolog, subfamily B, member 4 C00029919
1948 EFNB2, EPLG5, HTKL, Htk-L, LERK5 ephrin-B2 C00029919
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00029919
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00029919
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00029919
11153 FICD, HIP13, HYPE, UNQ3041 FIC domain containing (EC:2.7.7.n1) C00029919
2322 FLT3, CD135, FLK-2, FLK2, STK1 fms-related tyrosine kinase 3 (EC:2.7.10.1) C00029919
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00029919
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00029919
54676 GTPBP2 GTP binding protein 2 C00029919
29923 HILPDA, C7orf68, HIG-2, HIG2 hypoxia inducible lipid droplet-associated C00029919
3157 HMGCS1, HMGCS 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10) C00029919
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00029919
3320 HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 C00029919
3303 HSPA1A, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1 heat shock 70kDa protein 1A C00029919
3304 HSPA1B, HSP70-1B, HSP70-2 heat shock 70kDa protein 1B C00029919
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00029919
10808 HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25 heat shock 105kDa/110kDa protein 1 C00029919
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00029919
3458 IFNG, IFG, IFI interferon, gamma C00029919
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00029919
3557 IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4 interleukin 1 receptor antagonist C00029919
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00029919
182 JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 jagged 1 C00029919
3781 KCNN2, KCa2.2, SK2, SKCA2, SKCa_2, hSK2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 C00029919
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00029919
23175 LPIN1, PAP1 lipin 1 (EC:3.1.3.4) C00029919
26046 LTN1, C21orf10, C21orf98, RNF160, ZNF294 listerin E3 ubiquitin protein ligase 1 C00029919
9935 MAFB, KRML, MCTO v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B C00029919
4191 MDH2, M-MDH, MDH, MGC:3559, MOR1 malate dehydrogenase 2, NAD (mitochondrial) (EC:1.1.1.37) C00029919
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00029919
4335 MNT, MAD6, MXD6, ROX, bHLHd3 MAX network transcriptional repressor C00029919
29074 MRPL18, L18mt, MRP-L18 mitochondrial ribosomal protein L18 C00029919
2956 MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160 mutS homolog 6 C00029919
6307 MSMO1, DESP4, ERG25, SC4MOL methylsterol monooxygenase 1 (EC:1.14.13.72) C00029919
23077 MYCBP2, PAM MYC binding protein 2, E3 ubiquitin protein ligase C00029919
55892 MYNN, OSZF, ZBTB31, ZNF902 myoneurin C00029919
4683 NBN, AT-V1, AT-V2, ATV, NBS, NBS1, P95 nibrin C00029919
4824 NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A NK3 homeobox 1 C00029919
9315 NREP, C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17 neuronal regeneration related protein C00029919
4986 OPRK1, K-OR-1, KOR, KOR-1, OPRK opioid receptor, kappa 1 C00029919
51526 OSER1, C20orf111, HSPC207, Osr1, Perit1, dJ1183I21.1 oxidative stress responsive serine-rich 1 C00029919
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00029919
5152 PDE9A, HSPDE9A2 phosphodiesterase 9A (EC:3.1.4.35) C00029919
5293 PIK3CD, P110DELTA, PI3K, p110D phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153) C00029919
5295 PIK3R1, AGM7, GRB1, p85, p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) C00029919
10105 PPIF, CYP3, CyP-M, Cyp-D, CypD peptidylprolyl isomerase F (EC:5.2.1.8) C00029919
5813 PURA, PUR-ALPHA, PUR1, PURALPHA purine-rich element binding protein A C00029919
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00029919
6241 RRM2, R2, RR2, RR2M ribonucleotide reductase M2 (EC:1.17.4.1) C00029919
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00029919
27230 SERP1, RAMP4 stress-associated endoplasmic reticulum protein 1 C00029919
27244 SESN1, PA26, SEST1 sestrin 1 C00029919
6520 SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE solute carrier family 3 (amino acid transporter heavy chain), member 2 C00029919
23657 SLC7A11, CCBR1, xCT solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 C00029919
79811 SLTM, Met SAFB-like, transcription modulator C00029919
6659 SOX4, EVI16 SRY (sex determining region Y)-box 4 C00029919
100380807 C00029919
10963 STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L stress-induced-phosphoprotein 1 C00029919
51347 TAOK3, DPK, JIK, MAP3K18 TAO kinase 3 (EC:2.7.11.1) C00029919
7113 TMPRSS2, PP9284, PRSS10 transmembrane protease, serine 2 (EC:3.4.21.-) C00029919
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00029919
8797 TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1 tumor necrosis factor receptor superfamily, member 10a C00029919
8795 TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 tumor necrosis factor receptor superfamily, member 10b C00029919
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00029919
10628 TXNIP, EST01027, HHCPA78, THIF, VDUP1 thioredoxin interacting protein C00029919
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00029919
7320 UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2 ubiquitin-conjugating enzyme E2B (EC:6.3.2.19) C00029919
7358 UGDH, GDH, UDP-GlcDH, UDPGDH, UGD UDP-glucose 6-dehydrogenase (EC:1.1.1.22) C00029919
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00029919
79084 WDR77, MEP-50, MEP50, Nbla10071, RP11-552M11.3, p44, p44/Mep50 WD repeat domain 77 C00029919
23099 ZBTB43, ZBTB22B, ZNF-X, ZNF297B zinc finger and BTB domain containing 43 C00029919
80149 ZC3H12A, MCPIP, MCPIP1, RP3-423B22.1, dJ423B22.1 zinc finger CCCH-type containing 12A C00029919

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (80)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#612244 Inflammatory bowel disease 13; ibd13 P08183
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (91)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
Q06710 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
Q06710 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)