Species

KNApSAcK Entry

Organism name Buxus sempervirens
Genus Buxus
Family Buxaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Buxus sempervirens
Linked NCBI taxonomy ID 4002
Linked level species

Family

Family in NCBI taxonomy Buxaceae
ID 4000

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (21)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005681 External link 512 Galactobuxin
No. 2 No. 15
C00004712 External link 512 Artemetin
/ 3,6,7,3',4'-Pentamethylquercetagetin
/ Quercetagetin 3,6,7,3',4'-pentamethyl ether
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL225700
C054132
0 / 5 No. 8 No. 15
C00001816 External link 512 (+)-Bebeerine
CHEMBL1169627
C066405
13 / 6 / 5 No. 10 No. 4
C00025479 External link 512 Buxaminol B
No. 292 No. 11
C00002241 External link 512 Buxamine E
No. 292 No. 11
C00049055 External link 512 (+)-Buxamine F
CHEMBL491333
No. 292 No. 11
C00025532 External link 512 Sempervirone
No. 845
C00025487 External link 512 Cyclobuxophylline O
No. 845
C00027648 External link 512 (Z)-Cyclobuxaphylamine
/ (-)-(Z)-Cyclobuxaphylamine
No. 845
C00025483 External link 512 Buxithienine M
No. 845
C00049054 External link 512 (+)-17-Oxocycloprotobuxine
CHEMBL492177
No. 845
C00002252 External link 512 Irehine
No. 916 No. 11
C00002247 External link 512 Cyclovirobuxine C
No. 917 No. 11
C00002246 External link 512 Cycloprotobuxine C
CHEMBL1976863
No. 917 No. 11
C00025485 External link 512 Buxozine C
No. 917 No. 11
C00025522 External link 512 N-Benzoylbuxodienine E
No. 1058
C00002244 External link 512 Cyclobuxine D
C083065
No. 1260 No. 11
C00025486 External link 512 Cyclobuxargentine G
No. 1260 No. 11
C00025531 External link 512 Semperviramidine
/ (+)-Semperviramidine
No. 1367
C00028644 External link 512 Na-Demethylsemperviraminone
/ (+)-Na-Demethylsemperviraminone
No. 4653
C00025523 External link 512 N-Benzoylcyclovirobuxenine E
No. 7441

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001816 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001816 1 / 1
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00001816 0 / 0
P42858 Huntingtin Unclassified protein C00001816 1 / 1
O75496 Geminin Unclassified protein C00001816 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001816 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001816 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001816 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001816 4 / 3
O43603 Galanin receptor type 2 Galanin receptor C00001816 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001816 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001816 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001816 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (5)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00004712
D004487 Edema C00004712
D006099 Granuloma C00004712
D007022 Hypotension C00004712
D007249 Inflammation C00004712