Species

KNApSAcK Entry

Organism name Cinnamomum spp.
Genus Cinnamomum
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cinnamomum
Linked NCBI taxonomy ID 13428
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002376 External link 512 Cyanidin 3-rutinoside
CHEMBL505251
C020386
3 / 0 / 1 No. 1 No. 15
C00002934 External link 512 Proanthocyanidin A2
/ Proanthocyanidin A-2
/ (+)-Proanthocyanidin A-2
CHEMBL286933
CHEMBL81646
CHEMBL450916
C473740
13 / 3 / 4 No. 16 No. 19
C00009075 External link 512 Procyanidin B1
/ Epicatechin-(4beta->8)-catechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479579
20 / 7 / 8 No. 16 No. 19
C00009277 External link 512 Proanthocyanidin A1
CHEMBL286933
CHEMBL81646
CHEMBL450916
13 / 3 / 4 No. 16 No. 19
C00009077 External link 512 Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479580
20 / 7 / 8 10 / 0 No. 16 No. 19
C00009076 External link 512 Procyanidin B5
/ Epicatechin-(4beta-6)-epicatechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
CHEMBL445740
CHEMBL448700
2 / 3 / 7 No. 478 No. 38
C00000170 External link 512 trans-Cinnamate
/ trans-Cinnamic acid
CHEMBL27246
5 / 2 / 2 No. 904 No. 6
C00010932 External link 512 (S)-(-)-alpha-Terpineol
/ (S)-(-)-p-Menth-1-en-8-ol
CHEMBL447597
CHEMBL449810
3 / 16 / 11 No. 983 No. 35
C00010931 External link 512 (R)-(+)-alpha-Terpineol
/ (R)-(+)-p-Menth-1-en-8-ol
CHEMBL447597
CHEMBL449810
3 / 16 / 11 No. 983 No. 35
C00000619 External link 512 Eugenol
CHEMBL42710
D005054
103 / 45 / 36 152 / 28 No. 1852 No. 6

Human Protein / Gene in interactions

129 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17252 Protein kinase C alpha type Alpha C00000619 C00002934 C00009075 C00009077 C00009277 0 / 0
P05129 Protein kinase C gamma type Alpha C00002934 C00009075 C00009077 C00009277 1 / 1
P41743 Protein kinase C iota type Iota C00002934 C00009075 C00009077 C00009277 0 / 0
P24723 Protein kinase C eta type Eta C00002934 C00009075 C00009077 C00009277 1 / 0
P05771 Protein kinase C beta type Alpha C00002934 C00009075 C00009077 C00009277 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002934 C00009075 C00009077 C00009277 0 / 0
Q05655 Protein kinase C delta type Delta C00002934 C00009075 C00009077 C00009277 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002934 C00009075 C00009077 C00009277 0 / 0
Q05513 Protein kinase C zeta type Iota C00002934 C00009075 C00009077 C00009277 0 / 0
Q04759 Protein kinase C theta type Delta C00002934 C00009075 C00009077 C00009277 0 / 1
Q02156 Protein kinase C epsilon type Eta C00002934 C00009075 C00009077 C00009277 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000619 C00010931 C00010932 5 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000619 C00009075 C00009077 0 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000619 C00010931 C00010932 3 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000619 C00009075 C00009077 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000619 C00009075 C00009077 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000619 C00009075 C00009077 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000619 C00009075 C00009077 1 / 0
P02545 Prelamin-A/C Unclassified protein C00010931 C00010932 11 / 10
P16050 Arachidonate 15-lipoxygenase Enzyme C00009075 C00009077 0 / 0
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00009075 C00009077 0 / 0
P03372 Estrogen receptor NR3A1 C00000170 C00000619 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00009075 C00009077 3 / 3
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00009075 C00009077 0 / 0
P15692 Vascular endothelial growth factor A Secreted protein C00002934 C00009277 1 / 2
P49763 Placenta growth factor Unclassified protein C00002934 C00009277 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000619 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000619 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000619 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000619 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000619 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000170 1 / 1
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000619 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000619 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00000619 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000619 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000619 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000619 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000619 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000619 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000619 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000619 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000619 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000619 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000619 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000619 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000170 0 / 0
O75496 Geminin Unclassified protein C00000619 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000619 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000619 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000619 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000619 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000619 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000619 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000619 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000619 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000619 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000619 0 / 0
P15121 Aldose reductase Enzyme C00000170 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000619 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000619 0 / 0
P10145 Interleukin-8 Secreted protein C00000619 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000619 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000619 0 / 0
P08311 Cathepsin G S1A C00000619 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000619 1 / 0
P03956 Interstitial collagenase M10A C00000619 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000619 0 / 0
Q16611 Bcl-2 homologous antagonist/killer Unclassified protein C00002376 0 / 0
O43521 Bcl-2-like protein 11 Unclassified protein C00002376 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00000619 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000619 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000619 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000619 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000619 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000619 2 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000619 1 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000619 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000619 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000619 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000619 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000619 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000619 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000619 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000619 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000619 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000619 2 / 1
Q07812 Apoptosis regulator BAX Unclassified protein C00002376 0 / 1
P25021 Histamine H2 receptor Histamine receptor C00000619 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000619 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000619 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000619 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000619 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000619 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000619 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000619 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000619 2 / 2
P35372 Mu-type opioid receptor Opioid receptor C00000619 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000619 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000619 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000619 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000619 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000619 0 / 1
P00918 Carbonic anhydrase 2 Lyase C00000619 1 / 2
P27361 Mitogen-activated protein kinase 3 Erk C00000619 0 / 0
P29466 Caspase-1 C14 C00000619 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000619 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000619 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000619 0 / 0
P10275 Androgen receptor NR3C4 C00000619 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000619 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000619 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000619 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000619 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000619 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000619 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000619 0 / 0
O00255 Menin Unclassified protein C00003110 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003110 1 / 2
Q16539 Mitogen-activated protein kinase 14 p38 C00000619 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000619 0 / 0
P08246 Neutrophil elastase S1A C00000619 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000619 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000619 0 / 3
P21728 D(1A) dopamine receptor Dopamine receptor C00000619 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000619 0 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00000619 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000170 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000619 0 / 0

161 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00000619 C00009077
5733 PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R prostaglandin E receptor 3 (subtype EP3) C00000619
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00009077
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00009077
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00009077
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00009077
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00009077
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00009077
4240 MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 milk fat globule-EGF factor 8 protein C00009077
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00009077
23460 ABCA6, EST155051 ATP-binding cassette, sub-family A (ABC1), member 6 C00000619
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000619
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00000619
57016 AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) C00000619
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000619
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000619
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00000619
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00000619
55114 ARHGAP17, MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH1, RICH1B, WBP15 Rho GTPase activating protein 17 C00000619
10123 ARL4C, ARL7, LAK ADP-ribosylation factor-like 4C C00000619
567 B2M beta-2-microglobulin C00000619
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000619
9774 BCLAF1, BTF, bK211L9.1 BCL2-associated transcription factor 1 C00000619
654 BMP6, VGR, VGR1 bone morphogenetic protein 6 C00000619
699 BUB1, BUB1A, BUB1L, hBUB1 BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1) C00000619
57102 C12orf4 chromosome 12 open reading frame 4 C00000619
10203 CALCRL, CGRPR, CRLR calcitonin receptor-like C00000619
847 CAT catalase (EC:1.11.1.6) C00000619
6357 CCL13, CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1 chemokine (C-C motif) ligand 13 C00000619
6363 CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19 chemokine (C-C motif) ligand 19 C00000619
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000619
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00000619
6349 CCL3L1, 464.2, D17S1718, G0S19-2, LD78, LD78BETA, MIP1AP, SCYA3L, SCYA3L1 chemokine (C-C motif) ligand 3-like 1 C00000619
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00000619
729230 CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R chemokine (C-C motif) receptor 2 C00000619
1234 CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 chemokine (C-C motif) receptor 5 (gene/pseudogene) C00000619
1236 CCR7, BLR2, CD197, CDw197, CMKBR7, EBI1 chemokine (C-C motif) receptor 7 C00000619
948 CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 CD36 molecule (thrombospondin receptor) C00000619
942 CD86, B7-2, B7.2, B70, CD28LG2, LAB72 CD86 molecule C00000619
1385 CREB1, CREB cAMP responsive element binding protein 1 C00000619
1390 CREM, CREM-2, ICER, hCREM-2 cAMP responsive element modulator C00000619
1514 CTSL, CATL, CTSL1, MEP cathepsin L (EC:3.4.22.15) C00000619
2919 CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) C00000619
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00000619
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000619
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000619
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000619
1593 CYP27A1, CP27, CTX, CYP27 cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) C00000619
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000619
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00000619
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00000619
1736 DKC1, CBF5, DKC, DKCX, NAP57, NOLA4, XAP101 dyskeratosis congenita 1, dyskerin C00000619
9787 DLGAP5, DLG7, HURP discs, large (Drosophila) homolog-associated protein 5 C00000619
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00000619
1870 E2F2, E2F-2 E2F transcription factor 2 C00000619
1871 E2F3, E2F-3 E2F transcription factor 3 C00000619
1874 E2F4, E2F-4 E2F transcription factor 4, p107/p130-binding C00000619
1875 E2F5, E2F-5 E2F transcription factor 5, p130-binding C00000619
1876 E2F6, E2F-6 E2F transcription factor 6 C00000619
1959 EGR2, AT591, CMT1D, CMT4E, KROX20 early growth response 2 C00000619
133418 EMB embigin C00000619
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000619
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000619
2162 F13A1, F13A coagulation factor XIII, A1 polypeptide (EC:2.3.2.13) C00000619
26268 FBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2 F-box protein 9 C00000619
2213 FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2 Fc fragment of IgG, low affinity IIb, receptor (CD32) C00000619
2235 FECH, EPP, FCE ferrochelatase (EC:4.99.1.1) C00000619
2355 FOSL2, FRA2 FOS-like antigen 2 C00000619
2512 FTL, NBIA3 ferritin, light polypeptide C00000619
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00000619
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00000619
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00000619
644076 GLYCAM1 glycosylation dependent cell adhesion molecule 1 (pseudogene) C00000619
2878 GPX3, GPx-P, GSHPx-3, GSHPx-P glutathione peroxidase 3 (plasma) (EC:1.11.1.9) C00000619
2936 GSR glutathione reductase (EC:1.8.1.7) C00000619
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00000619
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00000619
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000619
2994 GYPB, CD235b, GPB, GPB.NY, GYPHe.NY, GpMiIII, HGpMiIII, HGpMiVI, HGpMiX, MNS, PAS-3, SS glycophorin B (MNS blood group) C00000619
54497 HEATR5B HEAT repeat containing 5B C00000619
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00000619
3106 HLA-B, AS, HLAB, SPDA1 major histocompatibility complex, class I, B C00000619
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000619
220988 HNRNPA3, 2610510D13Rik, D10S102, FBRNP, HNRPA3 heterogeneous nuclear ribonucleoprotein A3 C00000619
3381 IBSP, BNSP, BSP, BSP-II, SP-II integrin-binding sialoprotein C00000619
3422 IDI1, IPP1, IPPI1 isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) C00000619
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000619
7850 IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB interleukin 1 receptor, type II C00000619
3575 IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA interleukin 7 receptor C00000619
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000619
26034 IPCEF1, PIP3-E, RP3-402L9.2 interaction protein for cytohesin exchange factors 1 C00000619
3655 ITGA6, CD49f, ITGA6B, VLA-6 integrin, alpha 6 C00000619
3688 ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) C00000619
3741 KCNA5, ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1 potassium voltage-gated channel, shaker-related subfamily, member 5 C00000619
3759 KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3 potassium inwardly-rectifying channel, subfamily J, member 2 C00000619
9493 KIF23, CHO1, KNSL5, MKLP-1, MKLP1 kinesin family member 23 C00000619
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000619
4097 MAFG, hMAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G C00000619
7975 MAFK, NFE2U, P18 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K C00000619
28985 MCTS1, MCT-1, MCT1 malignant T cell amplified sequence 1 C00000619
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00000619
4257 MGST1, GST12, MGST, MGST-I microsomal glutathione S-transferase 1 (EC:2.5.1.18) C00000619
51318 MRPL35, L35mt, MRP-L35 mitochondrial ribosomal protein L35 C00000619
58475 MS4A7, 4SPAN2, CD20L4, CFFM4, MS4A8 membrane-spanning 4-domains, subfamily A, member 7 C00000619
4501 MT1X, MT-1l, MT1 metallothionein 1X C00000619
4084 MXD1, BHLHC58, MAD, MAD1 MAX dimerization protein 1 C00000619
4602 MYB, Cmyb, c-myb, c-myb_CDS, efg v-myb avian myeloblastosis viral oncogene homolog C00000619
10135 NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN nicotinamide phosphoribosyltransferase (EC:2.4.2.12) C00000619
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000619
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00000619
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00000619
4927 NUP88 nucleoporin 88kDa C00000619
10606 PAICS, ADE2, ADE2H1, AIRC, PAIS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21) C00000619
5142 PDE4B, DPDE4, PDE4B5, PDEIVB phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) C00000619
5226 PGD, 6PGD phosphogluconate dehydrogenase (EC:1.1.1.44) C00000619
8301 PICALM, CALM, CLTH, LAP phosphatidylinositol binding clathrin assembly protein C00000619
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000619
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00000619
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00000619
10935 PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III peroxiredoxin 3 (EC:1.11.1.15) C00000619
581 BAX, BCL2L4 BCL2-associated X protein C00009077
22949 PTGR1, LTB4DH, PGR1, ZADH3 prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) C00000619
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000619
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000619
5996 RGS1, 1R20, BL34, IER1, IR20 regulator of G-protein signaling 1 C00000619
6157 RPL27A, L27A ribosomal protein L27a C00000619
50484 RRM2B, MTDPS8A, MTDPS8B, P53R2 ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1) C00000619
6303 SAT1, DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57) C00000619
6383 SDC2, CD362, HSPG, HSPG1, SYND2 syndecan 2 C00000619
55752 SEPT11 septin 11 C00000619
6504 SLAMF1, CD150, CDw150, SLAM signaling lymphocytic activation molecule family member 1 C00000619
117247 SLC16A10, MCT10, PRO0813, TAT1 solute carrier family 16 (aromatic amino acid transporter), member 10 C00000619
6515 SLC2A3, GLUT3 solute carrier family 2 (facilitated glucose transporter), member 3 C00000619
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000619
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00000619
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00000619
140809 SRXN1, C20orf139, Npn3, SRX, SRX1 sulfiredoxin 1 (EC:1.8.98.2) C00000619
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000619
6775 STAT4, SLEB11 signal transducer and activator of transcription 4 C00000619
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000619
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00000619
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000619
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00000619
7130 TNFAIP6, TSG-6, TSG6 tumor necrosis factor, alpha-induced protein 6 C00000619
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000619
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00000619
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000619
25828 TXN2, MT-TRX, MTRX, TRX2 thioredoxin 2 C00000619
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000619
10587 TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2 thioredoxin reductase 2 (EC:1.8.1.9) C00000619
7358 UGDH, GDH, UDP-GlcDH, UDPGDH, UGD UDP-glucose 6-dehydrogenase (EC:1.1.1.22) C00000619
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000619
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000619
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00000619
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000619
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000619
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000619
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000619
7367 UGT2B17, BMND12, UDPGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17) C00000619
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00000619
7709 ZBTB17, MIZ-1, ZNF151, ZNF60, pHZ-67 zinc finger and BTB domain containing 17 C00000619

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (66)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#603933 Microvascular complications of diabetes, susceptibility to, 1; mvcd1 P15692
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (60)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P15692 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00021 Renal cell carcinoma P15692 (marker)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00020 Colorectal cancer Q07812 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

28 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001943 Breast Neoplasms C00000619
D017449 Dermatitis, Allergic Contact C00000619
D003877 Dermatitis, Contact C00000619
D003875 Drug Eruptions C00000619
D056486 Drug-Induced Liver Injury C00000619
D006331 Heart Diseases C00000619
D006461 Hemolysis C00000619
D006930 Hyperalgesia C00000619
D006967 Hypersensitivity C00000619
D007249 Inflammation C00000619
D008545 Melanoma C00000619
D009361 Neoplasm Invasiveness C00000619
D009362 Neoplasm Metastasis C00000619
D009374 Neoplasms, Experimental C00000619
D009389 Neovascularization, Pathologic C00000619
D009410 Nerve Degeneration C00000619
D010146 Pain C00000619
D010149 Pain, Postoperative C00000619
D010300 Parkinson Disease C00000619
D011833 Radiation Injuries, Experimental C00000619
D012481 Salmonella Infections, Animal C00000619
D012878 Skin Neoplasms C00000619
D013035 Spasm C00000619
D013203 Staphylococcal Infections C00000619
D013274 Stomach Neoplasms C00000619
D013276 Stomach Ulcer C00000619
D014581 Urticaria C00000619
D002583 Uterine Cervical Neoplasms C00000619