Species

KNApSAcK Entry

Organism name Anabasis aphylla
Genus Anabasis
Family Chenopodiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Anabasis aphylla
Linked NCBI taxonomy ID 454461
Linked level species

Family

Family in NCBI taxonomy Amaranthaceae
ID 3563

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002209 External link 512 Aphylline
CHEMBL509343
No. 85 No. 3
C00002226 External link 512 (-)-Lupinine
CHEMBL459397
CHEMBL1435718
C015971
1 / 1 / 1 No. 1838 No. 3
C00002015 External link 512 (-)-Anabasine
CHEMBL280963
CHEMBL1496898
CHEMBL1526229
D000691
15 / 18 / 15 0 / 4 No. 2084 No. 1

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002015 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002015 4 / 1
P06746 DNA polymerase beta Enzyme C00002015 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002015 0 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00002015 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00002015 1 / 1
P39748 Flap endonuclease 1 Enzyme C00002015 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002015 7 / 3
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00002015 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002015 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002015 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002015 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002015 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002226 1 / 1
O00255 Menin Unclassified protein C00002015 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002015 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (16)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001259 Ataxia C00002015
D006948 Hyperkinesis C00002015
D018908 Muscle Weakness C00002015
D014202 Tremor C00002015