Species

KNApSAcK Entry

Organism name Ostericum koreanum
Genus Ostericum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ostericum grosseserratum
Linked NCBI taxonomy ID 182415
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00031084 External link 512 Prim-O-Glucosylcimifugin
C00029558 External link 512 5-Caffeoylquinic acid methyl ester
CHEMBL416955
CHEMBL596924
CHEMBL1765881
CHEMBL1765882
CHEMBL2048503
CHEMBL2349427
6 / 5 / 4 No. 314 No. 6
C00029680 External link 512 Ammajin
/ Marmesinin
/ (-)-Marmesinin
CHEMBL459825
11 / 8 / 6 No. 399 No. 25
C00019796 External link 512 Bergaptol-O-beta-D-glucopyranoside
C067416
No. 491 No. 25
C00029480 External link 512 3,4-di-O-Caffeoylquinic acid
/ (-)-4,5-Dicaffeoyl quinic acid
CHEMBL358821
CHEMBL149674
CHEMBL177126
CHEMBL249448
CHEMBL453276
CHEMBL453537
CHEMBL1972460
2 / 0 / 0 No. 518 No. 6
C00029481 External link 512 3,5-di-O-caffeate
/ sochlorogenic acid a
/ 3,5-Dicaffeoylquinic acid
CHEMBL441250
CHEMBL249447
2 / 0 / 0 No. 518 No. 6
C00030905 External link 512 Oxypeucedanin hydrate
/ (+)-Oxypeucedanin hydrate
CHEMBL454060
CHEMBL1438253
13 / 5 / 8 No. 579 No. 25
C00002668 External link 512 Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid
CHEMBL37537
C009091
33 / 19 / 19 2 / 0 No. 817 No. 81
C00002421 External link 512 Cimifugin
No. 1426 No. 15
C00031338 External link 512 sec-O-Glucosylhamaudol
CHEMBL2059295
No. 5060
C00030658 External link 512 Ligustiphenol
/ (-)-Ligustiphenol
No. 6953

Human Protein / Gene in interactions

48 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00002668 C00029680 C00030905 0 / 0
O75496 Geminin Unclassified protein C00002668 C00029680 C00030905 0 / 0
P15121 Aldose reductase Enzyme C00002668 C00029480 C00029481 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002668 C00029680 C00030905 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00029480 C00029481 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002668 C00030905 0 / 0
P08254 Stromelysin-1 M10A C00002668 C00029558 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002668 C00029680 1 / 1
P14780 Matrix metalloproteinase-9 M10A C00002668 C00029558 2 / 2
P08253 72 kDa type IV collagenase M10A C00002668 C00029558 1 / 3
P06746 DNA polymerase beta Enzyme C00002668 C00030905 0 / 0
P03956 Interstitial collagenase M10A C00002668 C00029558 0 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002668 C00030905 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002668 C00030905 1 / 4
P17405 Sphingomyelin phosphodiesterase Enzyme C00029680 C00030905 2 / 2
Q9Y253 DNA polymerase eta Enzyme C00030905 1 / 1
P16581 E-selectin Adhesion C00002668 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002668 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002668 1 / 2
P23280 Carbonic anhydrase 6 Lyase C00002668 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00029680 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00002668 0 / 0
P07711 Cathepsin L1 C1A C00002668 0 / 0
Q9GZT9 Egl nine homolog 1 Enzyme C00002668 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00029680 0 / 0
P02768 Serum albumin Secreted protein C00002668 0 / 0
P06280 Alpha-galactosidase A Enzyme C00029680 1 / 1
P45452 Collagenase 3 M10A C00029558 1 / 1
P56817 Beta-secretase 1 A1A C00030905 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002668 0 / 1
P00918 Carbonic anhydrase 2 Lyase C00002668 1 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00029680 2 / 2
P03372 Estrogen receptor NR3A1 C00002668 1 / 1
P22303 Acetylcholinesterase Hydrolase C00029680 1 / 0
P14151 L-selectin Adhesion C00002668 0 / 0
P16109 P-selectin Adhesion C00002668 1 / 0
P39900 Macrophage metalloelastase M10A C00029558 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00030905 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002668 4 / 3
P22894 Neutrophil collagenase M10A C00002668 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00002668 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00030905 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002668 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00029680 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002668 3 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002668 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002668 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00030905 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002668
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC:4.2.1.11) C00002668

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#600807 Asthma, susceptibility to Q13093
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#143860 Hyperchlorhidrosis, isolated O43570
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#600852 Retinitis pigmentosa 17; rp17 P22748
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (25)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)