Species

KNApSAcK Entry

Organism name Ferula syreitschikowii
Genus Ferula
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ferula
Linked NCBI taxonomy ID 52470
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00035717 External link 512 (+)-Oxypeucedanin
/ Oxypeucedanin hydrate
CHEMBL454060
CHEMBL1438253
13 / 5 / 8 No. 579 No. 25
C00033364 External link 512 Saxalin
No. 579 No. 25
C00002477 External link 512 Imperatorin
CHEMBL453805
C031534
18 / 7 / 6 1 / 1 No. 606 No. 25
C00002490 External link 512 Oxypeucedanin
CHEMBL510120
CHEMBL1510267
CHEMBL1609439
C031535
8 / 14 / 11 No. 2896 No. 25

Human Protein / Gene in interactions

30 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A C00002477 C00002490 C00035717 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002477 C00035717 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002477 C00002490 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002490 C00035717 0 / 0
P06746 DNA polymerase beta Enzyme C00002490 C00035717 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002477 C00035717 1 / 1
O75496 Geminin Unclassified protein C00002490 C00035717 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002477 C00002490 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002477 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00035717 2 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00002477 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002477 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00035717 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00035717 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002477 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00002477 2 / 3
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00002477 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002477 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002477 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00035717 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002477 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00002490 3 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00035717 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002490 11 / 10
O00167 Eyes absent homolog 2 Enzyme C00002477 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002477 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002477 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00035717 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00035717 1 / 4
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002477 2 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002477

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (24)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002477