Species

KNApSAcK Entry

Organism name Angelica komarovii
Genus Angelica
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Angelica
Linked NCBI taxonomy ID 40948
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002477 External link 512 Imperatorin
CHEMBL453805
C031534
18 / 7 / 6 1 / 1 No. 606 No. 25
C00030987 External link 512 Phellopterin
CHEMBL452751
C104601
7 / 18 / 10 No. 606 No. 25
C00034737 External link 512 Umbelliprenin
CHEMBL156127
8 / 3 / 3 No. 2038

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002477 C00030987 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002477 C00034737 0 / 0
P56817 Beta-secretase 1 A1A C00002477 C00030987 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002477 C00034737 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00002477 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00030987 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00002477 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002477 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00034737 2 / 2
P39748 Flap endonuclease 1 Enzyme C00034737 0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme C00030987 1 / 2
O75496 Geminin Unclassified protein C00034737 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002477 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00030987 7 / 3
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002477 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002477 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00002477 0 / 0
P37840 Alpha-synuclein Unclassified protein C00030987 4 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00034737 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002477 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00034737 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002477 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002477 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00030987 4 / 3
O00167 Eyes absent homolog 2 Enzyme C00002477 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002477 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00034737 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002477 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002477 2 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002477

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#127750 Dementia, lewy body; dlb P37840
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (18)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002477