Species

KNApSAcK Entry

Organism name Opopanax chironium
Genus Opopanax
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Opopanax
Linked NCBI taxonomy ID 63018
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002477 External link 512 Imperatorin
CHEMBL453805
C031534
18 / 7 / 6 1 / 1 No. 606 No. 25
C00037261 External link 512 Heraclenin
CHEMBL346814
CHEMBL500034
C047845
2 / 0 / 0 No. 2896 No. 25

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A C00002477 C00037261 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00002477 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002477 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00002477 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00002477 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002477 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002477 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002477 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002477 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002477 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002477 2 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002477 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002477 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002477 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00037261 0 / 0
O00167 Eyes absent homolog 2 Enzyme C00002477 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002477 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002477 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002477 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002477

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (6)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002477