Species

KNApSAcK Entry

Organism name Seseli gummiferum subsp.corymbosum
Genus Seseli
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Seseli
Linked NCBI taxonomy ID 40951
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00030015 External link 512 Corymbocoumarin
CHEMBL68513
CHEMBL129045
No. 224 No. 25
C00002488 External link 512 Osthol
/ Osthole
CHEMBL52229
C046627
12 / 6 / 5 7 / 4 No. 466 No. 25

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002488 0 / 0
P04062 Glucosylceramidase Enzyme C00002488 6 / 4
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002488 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002488 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002488 0 / 0
O75496 Geminin Unclassified protein C00002488 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002488 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002488 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002488 0 / 0
P56817 Beta-secretase 1 A1A C00002488 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002488 0 / 1
O14980 Exportin-1 Unclassified protein C00002488 0 / 0

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2180 ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) C00002488
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00002488
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002488
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002488
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00002488
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002488
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002488

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#168600 Parkinson disease, late-onset; pd P04062

KEGG DISEASE (5)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
C538231 Adenocarcinoma of lung C00002488
D003920 Diabetes Mellitus C00002488
D006943 Hyperglycemia C00002488
D009361 Neoplasm Invasiveness C00002488