Species

KNApSAcK Entry

Organism name Heracleum levskovii
Genus Heracleum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Heracleum
Linked NCBI taxonomy ID 40917
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000297 External link 512 Psoralen
CHEMBL164660
D005363
12 / 6 / 6 0 / 5 No. 1282 No. 25

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000297 1 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000297 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000297 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00000297 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000297 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000297 0 / 0
P56817 Beta-secretase 1 A1A C00000297 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000297 3 / 3
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000297 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000297 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000297 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000297 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714

KEGG DISEASE (6)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00000297
D002280 Carcinoma, Basal Cell C00000297
D017484 Dermatitis, Phototoxic C00000297
D056486 Drug-Induced Liver Injury C00000297
D011565 Psoriasis C00000297