Species

KNApSAcK Entry

Organism name Maclura pomifera
Genus Maclura
Family Moraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Maclura pomifera
Linked NCBI taxonomy ID 3496
Linked level species

Family

Family in NCBI taxonomy Moraceae
ID 3487

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (22)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004025 External link 512 Artocarpesin
/ 2',4',5,7-Tetrahydroxy-6-(3-methyl-2-butenyl)flavone
/ 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL1915458
1 / 4 / 1 No. 15 No. 15
C00002586 External link 512 Wighteone
/ Erythrinin B
/ 5,7,4'-Trihydroxy-6-prenylisoflavone
CHEMBL393222
2 / 1 / 1 No. 15 No. 15
C00004089 External link 512 6-Prenylapigenin
/ 6-C-Prenylapigenin
/ 5,7,4'-Trihydroxy-6-prenylflavone
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
No. 15 No. 15
C00002562 External link 512 Pomiferin
CHEMBL393136
37 / 43 / 61 No. 18 No. 15
C00002961 External link 512 Macluraxanthone
/ 3-Hydroxyblancoxanthone
CHEMBL478960
5 / 11 / 11 No. 18 No. 15
C00002555 External link 512 Osajin
CHEMBL238188
36 / 50 / 70 No. 18 No. 15
C00008467 External link 512 Lespedezaflavanone D
/ Euchrestaflavanone B
No. 19 No. 14
C00004053 External link 512 Cycloartocarpesin
/ 8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
CHEMBL221908
2 / 0 / 0 No. 24 No. 15
C00013432 External link 512 Carpachromene
/ 5,4'-Dihidroxy-6'',6''-dimethylpyrano[2'',3'':7,6]flavone
/ 5-Hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
No. 24 No. 15
C00011125 External link 512 Osajaxanthone
No. 24 No. 15
C00032369 External link 512 Toxyloxanthone B
CHEMBL482997
No. 24 No. 15
C00008331 External link 512 Euchrestaflavanone C
No. 39
C00008570 External link 512 Dihydromorin
CHEMBL465073
CHEMBL463453
3 / 2 / 5 No. 42 No. 14
C00011128 External link 512 8-Prenylxanthone
No. 47 No. 15
C00011126 External link 512 Alvaxanthone
CHEMBL478937
No. 47 No. 15
C00002968 External link 512 Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene
CHEMBL187265
C069053
9 / 10 / 7 4 / 0 No. 71 No. 15
C00019067 External link 512 5,4'-Dihydroxy-5''-(1-hydroxy-1-methylethyl)-4''-methoxyfurano[2'',3'':7,6]isoflavone
No. 139
C00019066 External link 512 5,4'-Dihydroxy-2''-(1-hydroxy-1-methylethyl)-3''-methoxyfurano[4'',5'':6,7]isoflavone
No. 139
C00002893 External link 512 Oxyresveratrol
/ 2,3,4,5'-Tetrahydroxystilbene
CHEMBL43065
20 / 32 / 49 No. 295 No. 13
C00013405 External link 512 Dinklagin C
/ (+)-5,7-Dihydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
No. 984
C00019068 External link 512 Laburnetin
/ 5,7,4',2''-Tetrahydroxy-6-[3''-methyl-3''-butenyl]isoflavone
No. 984
C00011092 External link 512 Toxyloxanthone C
CHEMBL459022
8 / 4 / 2 No. 1835

Human Protein / Gene in interactions

71 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002555 C00002562 C00002893 C00011092 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002555 C00002562 C00002893 C00011092 0 / 0
O00255 Menin Unclassified protein C00002555 C00002562 C00002961 2 / 5
Q16637 Survival motor neuron protein Unclassified protein C00002555 C00002562 C00002961 4 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002555 C00002562 C00002961 1 / 2
Q99700 Ataxin-2 Unclassified protein C00002555 C00002562 C00011092 1 / 1
O75496 Geminin Unclassified protein C00002555 C00002562 C00011092 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002555 C00002562 C00002893 7 / 37
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002555 C00002562 C00002893 1 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002555 C00002562 C00011092 2 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002555 C00002562 C00002893 4 / 2
P17405 Sphingomyelin phosphodiesterase Enzyme C00002555 C00002562 C00002893 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002555 C00002562 C00011092 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002555 C00002562 C00002961 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002555 C00002562 0 / 0
P37840 Alpha-synuclein Unclassified protein C00002562 C00002893 4 / 2
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00002562 C00011092 0 / 0
P08254 Stromelysin-1 M10A C00002893 C00002968 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002555 C00002562 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002555 C00002562 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002893 C00008570 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002555 C00002562 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002893 C00002968 2 / 2
P39900 Macrophage metalloelastase M10A C00002893 C00002968 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002555 C00002562 0 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00002555 C00002562 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002562 C00002961 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002893 C00008570 0 / 3
P01215 Glycoprotein hormones alpha chain Unclassified protein C00002555 C00002562 0 / 3
P08253 72 kDa type IV collagenase M10A C00002893 C00002968 1 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002562 C00002893 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002555 C00002562 0 / 0
P03956 Interstitial collagenase M10A C00002893 C00002968 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00002555 C00002562 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002555 C00002562 1 / 1
P45452 Collagenase 3 M10A C00002893 C00002968 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002562 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002555 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00008570 2 / 2
P14679 Tyrosinase Oxidoreductase C00002893 4 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00002893 4 / 4
P11021 78 kDa glucose-regulated protein Unclassified protein C00002555 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002562 7 / 3
O75908 Sterol O-acyltransferase 2 Enzyme C00004053 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002586 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002893 0 / 0
P03372 Estrogen receptor NR3A1 C00002586 1 / 1
P12821 Angiotensin-converting enzyme M2 C00002968 4 / 2
P42858 Huntingtin Unclassified protein C00002555 1 / 1
P55210 Caspase-7 C14 C00002562 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00004025 4 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002562 1 / 1
P39748 Flap endonuclease 1 Enzyme C00002562 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002562 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00002555 1 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002562 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002555 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002562 0 / 1
P49327 Fatty acid synthase Transferase C00002968 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00002893 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002968 1 / 1
P02545 Prelamin-A/C Unclassified protein C00002555 11 / 10
P10253 Lysosomal alpha-glucosidase Hydrolase C00002555 1 / 1
O00167 Eyes absent homolog 2 Enzyme C00002555 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002555 0 / 0
P04062 Glucosylceramidase Enzyme C00002555 6 / 4
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00011092 0 / 0
P06746 DNA polymerase beta Enzyme C00002555 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002555 0 / 0
P35610 Sterol O-acyltransferase 1 Enzyme C00004053 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002562 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002968
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002968
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00002968
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (85)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P31749
P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P31749
P84022
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#615109 Cowden syndrome 6; cws6 P31749
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#176920 Proteus syndrome P31749
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#267430 Renal tubular dysgenesis; rtd P12821
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P12821
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (89)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00028 Choriocarcinoma P03956 (related)
P04637 (related)
P08253 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)