Species

KNApSAcK Entry

Organism name Polygala macradenia
Genus Polygala
Family Polygalaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Polygala macradenia
Linked NCBI taxonomy ID 174543
Linked level species

Family

Family in NCBI taxonomy Polygalaceae
ID 4274

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002594 External link 512 4'-Demethyldeoxypodophyllotoxin
CHEMBL89905
CHEMBL141117
CHEMBL1707682
CHEMBL1969951
27 / 14 / 4 No. 427 No. 21

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002594 2 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002594 2 / 0
O75496 Geminin Unclassified protein C00002594 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002594 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002594 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002594 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002594 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002594 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002594 1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00002594 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00002594 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00002594 0 / 0
P68366 Tubulin alpha-4A chain Structural C00002594 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00002594 1 / 0
P04350 Tubulin beta-4A chain Structural C00002594 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00002594 0 / 0
P07437 Tubulin beta chain Structural C00002594 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00002594 1 / 1
P68371 Tubulin beta-4B chain Structural C00002594 0 / 0
Q13509 Tubulin beta-3 chain Structural C00002594 2 / 1
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00002594 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00002594 0 / 0
Q13885 Tubulin beta-2A chain Structural C00002594 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00002594 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00002594 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00002594 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00002594 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
Q14191
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#137800 Glioma susceptibility 1; glm1 O75874
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (4)

KEGG name UniProt
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)