Species

KNApSAcK Entry

Organism name Tarenna attenuata
Genus Tarenna
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tarenna
Linked NCBI taxonomy ID 58440
Linked level genus

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00039281 External link 512 Glycosmisic acid
CHEMBL2346742
No. 215 No. 23
C00033656 External link 512 Balanophonin
/ (-)-Balanophonin
CHEMBL253335
CHEMBL468666
CHEMBL590760
CHEMBL1956166
No. 215 No. 23
C00032977 External link 512 Ficusal
/ (+)-Ficusal
No. 215 No. 23
C00002775 External link 512 Sinapaldehyde
/ Sinapic aldehyde
CHEMBL225067
C075386
No. 310 No. 6
C00039440 External link 512 Isoferulaldehyde
CHEMBL53781
2 / 2 / 11 No. 310 No. 6
C00038661 External link 512 Buddlenol E
CHEMBL1761717
No. 428
C00038660 External link 512 Buddlenol D
No. 428
C00038658 External link 512 Buddlenol A
CHEMBL221879
No. 428
C00038659 External link 512 Buddlenol C
No. 428
C00039028 External link 512 Dihydrocubebin
/ (-)-Dihydrocubebin
CHEMBL486597
CHEMBL1477391
C011228
4 / 8 / 4 No. 629 No. 21
C00029961 External link 512 Cinnamic acid
/ .beta-Phenylacrylic acid
CHEMBL27246
C029010
5 / 2 / 2 16 / 2 No. 904 No. 6
C00030463 External link 512 Hedyotisol A
CHEMBL388779
CHEMBL1761832
No. 907
C00039300 External link 512 Guaiacylglycerol
CHEMBL1078124
No. 1736
C00029477 External link 512 beta-Hydroxypropiovanillone
/ omega-Hydroxypropioguaiacone
/ 3,4'-Dihydroxy-3'-methoxypropiophenone
/ 3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone
CHEMBL485875
No. 2959
C00038323 External link 512 7-O-Ethylguaiacylglycerol
/ (-)-7-O-Ethylguaiacylglycerol
CHEMBL224843
No. 5619

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 C00039028 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00029961 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00029961 1 / 1
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00039440 1 / 3
P24385 G1/S-specific cyclin-D1 Other cytosolic protein C00039440 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00029961 0 / 0
P15121 Aldose reductase Enzyme C00029961 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00039028 7 / 3
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00039028 1 / 0
P03372 Estrogen receptor NR3A1 C00029961 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00039028 0 / 1
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1586 CYP17A1, CPT7, CYP17, P450C17, S17AH cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) C00029961
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00029961
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00029961
1558 CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) C00029961
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00029961
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00029961
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00029961
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00029961
338442 HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g hydroxycarboxylic acid receptor 2 C00029961
3284 HSD3B2, HSD3B, HSDB, SDR11E2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) C00029961
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00029961
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00029961
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00029961
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00029961
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00029961
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00029961

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#174800 Mccune-albright syndrome; mas P63092
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#254500 Myeloma, multiple P24385
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#278300 Xanthinuria, type i P47989

KEGG DISEASE (22)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00030 Cervical cancer P11802 (related)
H00038 Malignant melanoma P11802 (related)
H00042 Glioma P11802 (related)
H00006 Hairy-cell leukemia P24385 (related)
H00010 Multiple myeloma P24385 (related)
H00016 Oral cancer P24385 (related)
P24385 (marker)
H00017 Esophageal cancer P24385 (related)
P35354 (related)
H00031 Breast cancer P24385 (related)
H00055 Laryngeal cancer P24385 (related)
P24385 (marker)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00047 Gallbladder cancer P24385 (marker)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003384 Coxsackievirus Infections C00029961
D008545 Melanoma C00029961